Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.

Autor: Mabanglo MF; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Wilson B; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Noureldin M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Kimani SW; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Mamai A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Krausser C; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., González-Álvarez H; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Srivastava S; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Mohammed M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Hoffer L; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Chan M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Avrumutsoae J; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Li ASM; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Hajian T; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Tucker S; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Green S; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Szewczyk M; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Santhakumar V; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Ackloo S; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Loppnau P; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Li Y; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Seitova A; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Kiyota T; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Wang JG; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Privé GG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Kuntz DA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Patel B; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat, India., Rathod V; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat, India., Vala A; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat, India., Rout B; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat, India., Aman A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Poda G; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Uehling D; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Ramnauth J; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Halabelian L; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Marcellus R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada. ralawar@oicr.on.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. ralawar@oicr.on.ca.; Department of Chemistry, University of Toronto, Toronto, ON, Canada. ralawar@oicr.on.ca., Vedadi M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada. mvedadi@oicr.on.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. mvedadi@oicr.on.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 23; Vol. 15 (1), pp. 10165. Date of Electronic Publication: 2024 Nov 23.