Late onset Li-Fraumeni Syndrome with bilateral breast cancer and other malignancies: case report and review of the literature

Autor: Kast Karin, Krause Mechthild, Schuler Markus, Friedrich Katrin, Thamm Barbara, Bier Andrea, Distler Wolfgang, Krüger Stefan

Publikováno v: BMC Cancer, Vol 12, Iss 1, p 217 (2012)

Abstract Background Li-Fraumeni-Syndrome (LFS) is an autosomal-dominant, inherited tumour predisposition syndrome associated with heterozygous germline mutations in the TP53 gene. Patients with LFS are at a high risk to develop early-onset breast can

Externí odkaz: https://doaj.org/article/f58f9f45df9844be957459c0a286ebfa

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Differential Surface Adsorption Phenomena for Conventional and Novel Surfactants Correlates with Changes in Interfacial mAb Stabilization.

Autor: Kanthe AD; Sterile Product Development, Bristol Myers Squibb, New Brunswick, New Jersey 08901, United States.; Department of Chemical Engineering, The City College of New York, New York, New York 10031, United States., Carnovale MR; Pharma Solutions R&D, International Flavors and Fragrances, Wilmington, Delaware 19803, United States., Katz JS; Pharma Solutions R&D, International Flavors and Fragrances, Wilmington, Delaware 19803, United States., Jordan S; Pharma Solutions R&D, International Flavors and Fragrances, Wilmington, Delaware 19803, United States., Krause ME; Sterile Product Development, Bristol Myers Squibb, New Brunswick, New Jersey 08901, United States., Zheng S; Sterile Product Development, Bristol Myers Squibb, New Brunswick, New Jersey 08901, United States., Ilott A; Sterile Product Development, Bristol Myers Squibb, New Brunswick, New Jersey 08901, United States., Ying W; Sterile Product Development, Bristol Myers Squibb, New Brunswick, New Jersey 08901, United States., Bu W; NSF's ChemMatCARS, Center for Advanced Radiation Sources, University of Chicago, Chicago, Illinois 606371, United States., Bera MK; NSF's ChemMatCARS, Center for Advanced Radiation Sources, University of Chicago, Chicago, Illinois 606371, United States., Lin B; NSF's ChemMatCARS, Center for Advanced Radiation Sources, University of Chicago, Chicago, Illinois 606371, United States., Maldarelli C; Department of Chemical Engineering, The City College of New York, New York, New York 10031, United States.; Levich Institute, The City College of New York, New York, New York 10031, United States., Tu RS; Department of Chemical Engineering, The City College of New York, New York, New York 10031, United States.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2022 Sep 05; Vol. 19 (9), pp. 3100-3113. Date of Electronic Publication: 2022 Jul 26.

Chemical and physical instabilities in manufacturing and storage of therapeutic proteins.

Autor: Krause ME; Drug Product Science and Technology, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, NJ 08903, United States. Electronic address: Mary.Krause@bms.com., Sahin E; Drug Product Science and Technology, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, NJ 08903, United States.

Publikováno v: Current opinion in biotechnology [Curr Opin Biotechnol] 2019 Dec; Vol. 60, pp. 159-167. Date of Electronic Publication: 2019 Mar 09.

Small-Scale Tools to Assess the Impact of Interfacial and Shear Stress on Biologic Drug Products.

Autor: Ogunyankin MO; Department of Drug Product Science and Technology, Bristol-Myers Squibb, Inc., One Squibb Drive, New Brunswick, New Jersey, 08901, USA. mariaolu.ogunyankin@bms.com., Deshmukh S; Department of Drug Product Science and Technology, Bristol-Myers Squibb, Inc., One Squibb Drive, New Brunswick, New Jersey, 08901, USA. smeet.deshmukh@gmail.com.; Department of Pharmaceutical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, New Jersey, 07033, USA. smeet.deshmukh@gmail.com., Krause ME; Department of Drug Product Science and Technology, Bristol-Myers Squibb, Inc., One Squibb Drive, New Brunswick, New Jersey, 08901, USA., Carvalho T; Department of Drug Product Science and Technology, Bristol-Myers Squibb, Inc., One Squibb Drive, New Brunswick, New Jersey, 08901, USA., Huang M; Department of Drug Product Science and Technology, Bristol-Myers Squibb, Inc., One Squibb Drive, New Brunswick, New Jersey, 08901, USA., Ilott A; Department of Drug Product Science and Technology, Bristol-Myers Squibb, Inc., One Squibb Drive, New Brunswick, New Jersey, 08901, USA., Remy B; Department of Drug Product Science and Technology, Bristol-Myers Squibb, Inc., One Squibb Drive, New Brunswick, New Jersey, 08901, USA., Khossravi M; Department of Drug Product Science and Technology, Bristol-Myers Squibb, Inc., One Squibb Drive, New Brunswick, New Jersey, 08901, USA.

Publikováno v: AAPS PharmSciTech [AAPS PharmSciTech] 2019 May 06; Vol. 20 (5), pp. 184. Date of Electronic Publication: 2019 May 06.