Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Krastyu G Ugrinov"'
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121511 (2015)
Mucopolysaccharidosis type IIIA (MPS-IIIA, Sanfilippo syndrome) is a Lysosomal Storage Disease caused by cellular deficiency of N-sulfoglucosamine sulfohydrolase (SGSH). Given the large heterogeneity of genetic mutations responsible for the disease,
Externí odkaz:
https://doaj.org/article/bfbde9390ab04f37a040b471ac3c52ea
Autor:
Patricia L. Clark, Krastyu G. Ugrinov
Publikováno v:
Biophysical Journal. 98(7):1312-1320
Protein sequences evolved to fold in cells, including cotranslational folding of nascent polypeptide chains during their synthesis by the ribosome. The vectorial (N- to C-terminal) nature of cotranslational folding constrains the conformations of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de853bf78ac8d7a0cd1e0e1f0ac0f74e
Publikováno v:
Nature Methods. 2:757-762
Cotranslational protein maturation is often studied in cell-free translation mixtures, using stalled ribosome-nascent chain complexes produced by translating truncated mRNA. This approach has two limitations: (i) it can be technically challenging, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc54dc60634b0e4a0a17ad1ae8bb80f6
https://doi.org/10.1038/nmeth790
https://doi.org/10.1038/nmeth790
Autor:
Patricia L, Clark, Krastyu G, Ugrinov
Publikováno v:
Methods in enzymology. 466
Protein folding has been studied extensively in vitro, but much less is known about how folding proceeds in vivo. A particular distinction of folding in vivo is that folding begins while the nascent polypeptide chain is still undergoing synthesis by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70cce1c7bf2205182250e36a0a7b1a86
https://pubmed.ncbi.nlm.nih.gov/21609877
https://pubmed.ncbi.nlm.nih.gov/21609877
Autor:
Patricia L. Clark, Krastyu G. Ugrinov
Protein folding has been studied extensively in vitro, but much less is known about how folding proceeds in vivo. A particular distinction of folding in vivo is that folding begins while the nascent polypeptide chain is still undergoing synthesis by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::199087e3dc18ad091c9561ba93c51a01
https://doi.org/10.1016/s0076-6879(09)66024-9
https://doi.org/10.1016/s0076-6879(09)66024-9
