Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Krassimira Angelova"'
Autor:
Krassimira Angelova, Mariusz W. Szkudlinski, Valerie Fremont, David Puett, Meng Zhang, Renita Jain, Prema Narayan
Publikováno v:
Endocrine. 24:025-032
The alpha-subunit is common to the heterodimeric glycoprotein hormones and has been highly conserved throughout vertebrate evolution. In an effort to determine if wild-type and engineered human alpha analogs can serve as agonists or antagonists to th
Publikováno v:
Molecular and Cellular Endocrinology. 204:1-9
There is evidence that ligand binding to and ligand-mediated signaling by the luteinizing hormone receptor (LHR) are influenced by buffer conditions, including ionic type and strength, an issue that becomes important in comparing functional parameter
Publikováno v:
Protein & Peptide Letters. 9:153-158
In response to ligand binding and activating mutations, the lutropin receptor undergoes a conformational change to trigger a cellular response. D556 is the most common locus for naturally occurring activating mutations of the lutropin receptor, and a
Autor:
David Puett, Krassimira Angelova
Publikováno v:
Endocrine. 19:147-154
The glycoprotein hormone receptors-luteinizing hormone receptor (LHR), follicle-stimulating hormone receptor (FSHR), and thyroid-stimulating hormone receptor (TSHR)--are G-protein-coupled receptors with an invariant 10-amino acid residue sequence in
Publikováno v:
Molecular Endocrinology. 14:459-471
A member of the G protein-coupled receptor superfamily, the LH receptor (LHR), and the two other glycoprotein hormone receptors are distinguished from the other members by the presence of a relatively large N-terminal extracellular domain that is res
Publikováno v:
Endocrine. 7:287-293
Endothelin (ET) and its G-protein-coupled receptors are distributed in a wide variety of tissues, including the brain. In this study, we have identified and characterized the endothelin receptor subtypes in sheep choroid plexus. Competitive binding e
Publikováno v:
Neuroscience Letters. 225:1-4
The endothelin (ET) peptides, ET-1, ET-2, and ET-3, as well as the ETA and ETB receptor subtypes, are known to occur in brain, but there is a dearth of information on the metabolism of these peptides by the central nervous system (CNS). In this study
Publikováno v:
Regulatory Peptides. 66:155-162
The mechanism(s) of degradation of the potent vasoconstrictor endothelin-1 (ET-1) by rat vascular smooth muscle A-10 cells, which possess the ET A receptor subtype, was investigated by incubating [ 125 I]ET-1 (0.1 nM) with cells for 0–4 h at 37°C
Autor:
Francesca Fanelli, David Puett, Moon Lee, Angelo Nicola Felline, Manish Patel, Krassimira Angelova
The luteinizing hormone receptor (LHR) is a G protein-coupled receptor (GPCR) particularly susceptible to spontaneous pathogenic gain-of-function mutations. Protein structure network (PSN) analysis on wild-type LHR and two constitutively active mutan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c66f1f34d348e35d2aae6dd7b86ad1c
https://hdl.handle.net/11380/646531
https://hdl.handle.net/11380/646531
Multiple interactions exist between human follicle-stimulating hormone (FSH) and the N-terminal hormone-binding fragment of the human FSH receptor (FSHR) extracellular domain (ECD). Binding of the other human glycoprotein hormones to their cognate hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac6d57d413ad90e42045faddc0345bb
https://europepmc.org/articles/PMC2966097/
https://europepmc.org/articles/PMC2966097/