Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Krassimira, Idakieva"'
Autor:
Emiliya Stoyanova, Nikolina Mihaylova, Nikola Ralchev, Silviya Bradyanova, Iliyan Manoylov, Yuliana Raynova, Krassimira Idakieva, Andrey Tchorbanov
Publikováno v:
Marine Drugs, Vol 22, Iss 10, p 462 (2024)
Melanoma is one of the most common tumors worldwide, and new approaches and antitumor drugs for therapy are being investigated. Among the promising biomolecules of natural origin for antitumor research are gastropodan hemocyanins—highly immunogenic
Externí odkaz:
https://doaj.org/article/6060ec9bd7084ff7a0caffbbf2782aeb
Autor:
Emiliya Stoyanova, Nikolina Mihaylova, Nikola Ralchev, Silviya Bradyanova, Iliyan Manoylov, Yuliana Raynova, Krassimira Idakieva, Andrey Tchorbanov
Publikováno v:
Marine Drugs, Vol 22, Iss 5, p 220 (2024)
The development of antitumor drugs and therapy requires new approaches and molecules, and products of natural origin provide intriguing alternatives for antitumor research. Gastropodan hemocyanins-multimeric copper-containing glycoproteins have been
Externí odkaz:
https://doaj.org/article/536fdf99279347beb26bb404c9cfc328
Autor:
Krassimira Idakieva, Svetla Todinova, Aleksandar Dolashki, Lyudmila Velkova, Yuliana Raynova, Pavlina Dolashka
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 18-28 (2021)
The structural stability of the hеmocyanin purified from the hеmolymph of gаrden snаils Helix lucorum (HlH) was investigated by means of far-UV circular dichroism (CD), differential scanning calorimetry (DSC) and transmission electron microscopy
Externí odkaz:
https://doaj.org/article/af543371bf3b44e6b1b7f13f1113b61b
Publikováno v:
Acta Chimica Slovenica, Vol 67, Iss 1, Pp 253-259 (2020)
For the first time Helix lucorum hemocyanin (HlH) has been feruloylated. Two HlH conjugates with 40- and 120- ferulic acid residues were prepared, denoted as FA-HlH-1 and FA-HlH-2. Expectedly, the feruloylation of HlH induced a rearrangement of the p
Externí odkaz:
https://doaj.org/article/3051f549d25340d09dea72b6bc4e7728
Autor:
Emiliya Stoyanova, Nikolina Mihaylova, Nikola Ralchev, Petya Ganova, Silviya Bradyanova, Iliyan Manoylov, Yuliana Raynova, Krassimira Idakieva, Andrey Tchorbanov
Publikováno v:
Marine Drugs, Vol 20, Iss 6, p 392 (2022)
Finding new effective compounds of natural origin for composing anti-tumor vaccines is one of the main goals of antitumor research. Promising anti-cancer agents are the gastropodan hemocyanins–multimeric copper-containing glycoproteins used so far
Externí odkaz:
https://doaj.org/article/b434c656d8c546509b9c68df39d8142e
Autor:
Maya Guncheva, Krassimira Idakieva, Svetla Todinova, Denitsa Yancheva, Tsvetelina Paunova-Krasteva, Paula Ossowicz, Ewa Janus
Publikováno v:
Molecules, Vol 26, Iss 6, p 1714 (2021)
Novel biocompatible compounds that stabilize proteins in solution are in demand for biomedical and/or biotechnological applications. Here, we evaluated the effect of six ionic liquids, containing mono- or dicholinium [Chol]1or2 cation and anions of c
Externí odkaz:
https://doaj.org/article/552568e741244e30b9054aa6b6479a52
Publikováno v:
Journal of Analytical Methods in Chemistry, Vol 2018 (2018)
The thermal unfolding of hemocyanin isoforms, β-HaH and αD+N-HaH, isolated from the hemolymph of garden snails Helix aspersa maxima, was studied by means of differential scanning calorimetry (DSC). One transition, with an apparent transition temper
Externí odkaz:
https://doaj.org/article/47d318ac4d2642c69699c46eb069987e
Autor:
Lyudmila Velkova, Krassimira Idakieva, Svetla Todinova, Aleksandar Dolashki, Pavlina Dolashka, Yuliana Raynova
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 18-28 (2021)
The structural stability of the hеmocyanin purified from the hеmolymph of gаrden snаils Helix lucorum (HlH) was investigated by means of far-UV circular dichroism (CD), differential scanning calorimetry (DSC) and transmission electron microscopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c1f35d25a1dbecfaa4eb75e53b25bc
https://doaj.org/article/af543371bf3b44e6b1b7f13f1113b61b
https://doaj.org/article/af543371bf3b44e6b1b7f13f1113b61b
Publikováno v:
Journal of Thermal Analysis and Calorimetry. 142:1903-1909
Two oxygen-transporting proteins known for their immunostimulating and anticancer properties, namely hemocyanin from Helix lucorum (HlH) and hemocyanin from Rapana thomasiana (RtH), have been modified for the first time with rosmarinic acid (RA). We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::609fcfc87b366c5dc0c049a385b0a229
https://doi.org/10.1007/s10973-020-09738-0
https://doi.org/10.1007/s10973-020-09738-0
Publikováno v:
Journal of Thermal Analysis and Calorimetry. 138:2715-2720
This is the first report on the conjugation of a hemocyanin from Rapana thomasiana (RtH) with ferulic acid, which itself exhibits an immunostimulatory activity. In a two-step reaction, 20 to 180 ferulic acid residues were covalently linked to one mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b85fe50ba5686367e0859e71b76a227c
https://doi.org/10.1007/s10973-019-08373-8
https://doi.org/10.1007/s10973-019-08373-8