A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress.

Autor: Fedeles BI; Departments of Biological Engineering, Chemistry and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Bhardwaj R; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Ishikawa Y; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Khumsubdee S; Departments of Biological Engineering, Chemistry and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.; Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand., Krappitz M; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Gubina N; Departments of Biological Engineering, Chemistry and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Russia., Volpe I; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Andrade DC; Departments of Biological Engineering, Chemistry and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Westergerling P; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Staudner T; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Campolo J; Departments of Biological Engineering, Chemistry and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Liu SS; Departments of Biological Engineering, Chemistry and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Dong K; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Cai Y; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Rehman M; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Gallagher AR; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Ruchirawat S; Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand., Croy RG; Departments of Biological Engineering, Chemistry and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Essigmann JM; Departments of Biological Engineering, Chemistry and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Fedeles SV; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510., Somlo S; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT 06510.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jan 23; Vol. 121 (4), pp. e2317344121. Date of Electronic Publication: 2024 Jan 19.

XBP1 Activation Reduces Severity of Polycystic Kidney Disease due to a Nontruncating Polycystin-1 Mutation in Mice.

Autor: Krappitz M; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut.; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.; BIH Biomedical Innovation Academy, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Bhardwaj R; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut., Dong K; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut., Staudner T; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut., Yilmaz DE; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany., Pioppini C; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany., Westergerling P; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut., Ruemmele D; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut., Hollmann T; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut., Nguyen TA; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut., Cai Y; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut., Gallagher AR; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut., Somlo S; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut., Fedeles S; Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2023 Jan 01; Vol. 34 (1), pp. 110-121. Date of Electronic Publication: 2022 Oct 21.

Disrupting polycystin-2 EF hand Ca ²⁺ affinity does not alter channel function or contribute to polycystic kidney disease.

Autor: Vien TN; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Ng LCT; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Smith JM; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA., Dong K; Departments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Krappitz M; Departments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Gainullin VG; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA., Fedeles S; Departments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Harris PC; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA., Somlo S; Departments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., DeCaen PG; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA paul.decaen@northwestern.edu.

Publikováno v: Journal of cell science [J Cell Sci] 2020 Dec 24; Vol. 133 (24). Date of Electronic Publication: 2020 Dec 24.

In-Field Eigen Oscillation-Measurement for Detection of UV-Induced EVA-Degradation

Autor: Fromm, A., Trondl, A., Strecker, H., Habedank, M., Rees, F., Krappitz, M., Kübler, R.

28th European Photovoltaic Solar Energy Conference and Exhibition; 3131-3134
Photovoltaic-modules are exposed to static mechanical loads, such as snow and wind loads during conventional use. Wind also triggers oscillations. It is obvious that th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ea5aeae5ce843c24e9f38bddbae80dd

Decoding Polycystin-1's G-Proteolytic Site: Implications for Cell Interactions and Autosomal Dominent Polycystic Kidney Disease Pathogenesis.

Autor: Sonbol, Hala Salim¹ hsonbol@kau.edu.sa, Al-sirhani, Alaa Muqbil²

Publikováno v: Journal of Pioneering Medical Sciences. Jul2024, Vol. 13 Issue 4, p112-120. 9p.