RNA-encoded Interleukin 2 with Extended Bioavailability Amplifies RNA Vaccine-Induced Antitumor T-cell Immunity.

Autor: Peters D; BioNTech SE (Formerly TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH), Mainz, Germany., Kranz LM; BioNTech SE, Mainz, Germany., Eisel D; BioNTech SE, Mainz, Germany., Diken M; BioNTech SE, Mainz, Germany.; TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Mainz, Germany., Kreiter S; BioNTech SE, Mainz, Germany.; TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Mainz, Germany., Türeci Ö; BioNTech SE, Mainz, Germany.; HI-TRON-Helmholtz Institute for Translational Oncology Mainz by DKFZ, Mainz, Germany., Sahin U; BioNTech SE, Mainz, Germany.; Department of Translational Oncology and Immunology at the Institute of Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Vormehr M; BioNTech SE, Mainz, Germany.; Department of Translational Oncology and Immunology at the Institute of Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2024 Oct 01; Vol. 12 (10), pp. 1409-1420.

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans.

Autor: Sahin U; BioNTech, Mainz, Germany. Ugur.Sahin@biontech.de.; TRON gGmbH - Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany. Ugur.Sahin@biontech.de., Muik A; BioNTech, Mainz, Germany., Vogler I; BioNTech, Mainz, Germany., Derhovanessian E; BioNTech, Mainz, Germany., Kranz LM; BioNTech, Mainz, Germany., Vormehr M; BioNTech, Mainz, Germany., Quandt J; BioNTech, Mainz, Germany., Bidmon N; BioNTech, Mainz, Germany., Ulges A; BioNTech, Mainz, Germany., Baum A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA., Pascal KE; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA., Maurus D; BioNTech, Mainz, Germany., Brachtendorf S; BioNTech, Mainz, Germany., Lörks V; BioNTech, Mainz, Germany., Sikorski J; BioNTech, Mainz, Germany., Koch P; BioNTech, Mainz, Germany., Hilker R; BioNTech, Mainz, Germany., Becker D; BioNTech, Mainz, Germany., Eller AK; BioNTech, Mainz, Germany., Grützner J; BioNTech, Mainz, Germany., Tonigold M; BioNTech, Mainz, Germany., Boesler C; BioNTech, Mainz, Germany., Rosenbaum C; BioNTech, Mainz, Germany., Heesen L; BioNTech, Mainz, Germany., Kühnle MC; BioNTech, Mainz, Germany., Poran A; BioNTech US, Cambridge, MA, USA., Dong JZ; BioNTech US, Cambridge, MA, USA., Luxemburger U; BioNTech, Mainz, Germany., Kemmer-Brück A; BioNTech, Mainz, Germany., Langer D; BioNTech, Mainz, Germany., Bexon M; Bexon Clinical Consulting LLC, Upper Montclair, NJ, USA., Bolte S; BioNTech, Mainz, Germany., Palanche T; BioNTech, Mainz, Germany., Schultz A; CRS Clinical Research Services Mannheim GmbH, Mannheim, Germany., Baumann S; CRS Clinical Research Services Berlin GmbH, Berlin, Germany., Mahiny AJ; BioNTech, Mainz, Germany., Boros G; BioNTech, Mainz, Germany., Reinholz J; BioNTech, Mainz, Germany., Szabó GT; BioNTech, Mainz, Germany., Karikó K; BioNTech, Mainz, Germany., Shi PY; University of Texas Medical Branch, Galveston, TX, USA., Fontes-Garfias C; University of Texas Medical Branch, Galveston, TX, USA., Perez JL; Pfizer, Pearl River, NY, US., Cutler M; Pfizer, Pearl River, NY, US., Cooper D; Pfizer, Pearl River, NY, US., Kyratsous CA; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA., Dormitzer PR; Pfizer, Pearl River, NY, US., Jansen KU; Pfizer, Pearl River, NY, US., Türeci Ö; BioNTech, Mainz, Germany.

Publikováno v: Nature [Nature] 2021 Jul; Vol. 595 (7868), pp. 572-577. Date of Electronic Publication: 2021 May 27.

BNT162b vaccines protect rhesus macaques from SARS-CoV-2.

Autor: Vogel AB; BioNTech, Mainz, Germany., Kanevsky I; Pfizer, Pearl River, NY, USA., Che Y; Pfizer, Groton, CT, USA., Swanson KA; Pfizer, Pearl River, NY, USA., Muik A; BioNTech, Mainz, Germany., Vormehr M; BioNTech, Mainz, Germany., Kranz LM; BioNTech, Mainz, Germany., Walzer KC; BioNTech, Mainz, Germany., Hein S; BioNTech, Mainz, Germany., Güler A; BioNTech, Mainz, Germany., Loschko J; Pfizer, Pearl River, NY, USA., Maddur MS; Pfizer, Pearl River, NY, USA., Ota-Setlik A; Pfizer, Pearl River, NY, USA., Tompkins K; Pfizer, Pearl River, NY, USA., Cole J; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA., Lui BG; BioNTech, Mainz, Germany., Ziegenhals T; BioNTech, Mainz, Germany., Plaschke A; BioNTech, Mainz, Germany., Eisel D; BioNTech, Mainz, Germany., Dany SC; BioNTech, Mainz, Germany., Fesser S; BioNTech, Mainz, Germany., Erbar S; BioNTech, Mainz, Germany., Bates F; BioNTech, Mainz, Germany., Schneider D; BioNTech, Mainz, Germany., Jesionek B; BioNTech, Mainz, Germany., Sänger B; BioNTech, Mainz, Germany., Wallisch AK; BioNTech, Mainz, Germany., Feuchter Y; BioNTech, Mainz, Germany., Junginger H; BioNTech, Mainz, Germany., Krumm SA; BioNTech, Mainz, Germany., Heinen AP; BioNTech, Mainz, Germany., Adams-Quack P; BioNTech, Mainz, Germany., Schlereth J; BioNTech, Mainz, Germany., Schille S; BioNTech, Mainz, Germany., Kröner C; BioNTech, Mainz, Germany., de la Caridad Güimil Garcia R; BioNTech, Mainz, Germany., Hiller T; BioNTech, Mainz, Germany., Fischer L; BioNTech, Mainz, Germany., Sellers RS; Pfizer, Pearl River, NY, USA., Choudhary S; Pfizer, Pearl River, NY, USA., Gonzalez O; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA., Vascotto F; TRON-Translational Oncology at the University Medical Centre of the Johannes Gutenberg University, Mainz, Germany., Gutman MR; VCA SouthPaws Veterinary Specialists and Emergency Center, Fairfax, VA, USA., Fontenot JA; New Iberia Research Center, New Iberia, LA, USA., Hall-Ursone S; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA., Brasky K; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA., Griffor MC; Pfizer, Groton, CT, USA., Han S; Pfizer, Groton, CT, USA., Su AAH; BioNTech, Mainz, Germany., Lees JA; Pfizer, Groton, CT, USA., Nedoma NL; Pfizer, Groton, CT, USA., Mashalidis EH; Pfizer, Groton, CT, USA., Sahasrabudhe PV; Pfizer, Groton, CT, USA., Tan CY; Pfizer, Pearl River, NY, USA., Pavliakova D; Pfizer, Pearl River, NY, USA., Singh G; Pfizer, Pearl River, NY, USA., Fontes-Garfias C; University of Texas Medical Branch, Galveston, TX, USA., Pride M; Pfizer, Pearl River, NY, USA., Scully IL; Pfizer, Pearl River, NY, USA., Ciolino T; Pfizer, Pearl River, NY, USA., Obregon J; Pfizer, Pearl River, NY, USA., Gazi M; Texas Biomedical Research Institute, San Antonio, TX, USA., Carrion R Jr; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA., Alfson KJ; Texas Biomedical Research Institute, San Antonio, TX, USA., Kalina WV; Pfizer, Pearl River, NY, USA., Kaushal D; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA., Shi PY; University of Texas Medical Branch, Galveston, TX, USA., Klamp T; BioNTech, Mainz, Germany., Rosenbaum C; BioNTech, Mainz, Germany., Kuhn AN; BioNTech, Mainz, Germany., Türeci Ö; BioNTech, Mainz, Germany., Dormitzer PR; Pfizer, Pearl River, NY, USA., Jansen KU; Pfizer, Pearl River, NY, USA., Sahin U; BioNTech, Mainz, Germany. Ugur.Sahin@biontech.de.; TRON-Translational Oncology at the University Medical Centre of the Johannes Gutenberg University, Mainz, Germany. Ugur.Sahin@biontech.de.

Publikováno v: Nature [Nature] 2021 Apr; Vol. 592 (7853), pp. 283-289. Date of Electronic Publication: 2021 Feb 01.

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis.

Autor: Krienke C; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.; Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University, Langenbeckstr. 1, Mainz 55131, Germany., Kolb L; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany., Diken E; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany., Streuber M; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany., Kirchhoff S; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany., Bukur T; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany., Akilli-Öztürk Ö; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany., Kranz LM; Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany., Berger H; Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany., Petschenka J; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.; Cancer Immunology and Immune Modulation, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397 Biberach an der Riss, Germany., Diken M; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.; Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany., Kreiter S; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.; Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany., Yogev N; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University, Mainz 55131, Germany.; Clinic and Polyclinic for Dermatology and Venereology, University Hospital Cologne, Kerpenerstr. 62, Cologne 50937, Germany., Waisman A; Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University, Langenbeckstr. 1, Mainz 55131, Germany.; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University, Mainz 55131, Germany., Karikó K; Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany., Türeci Ö; Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany.; CI3 - Cluster for Individualized Immunointervention e.V., Hölderlinstraße 8, 55131 Mainz, Germany., Sahin U; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany. sahin@uni-mainz.de.; Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University, Langenbeckstr. 1, Mainz 55131, Germany.; Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany.

Publikováno v: Science (New York, N.Y.) [Science] 2021 Jan 08; Vol. 371 (6525), pp. 145-153.

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma.

Autor: Sahin U; BioNTech, Mainz, Germany. ugur.sahin@biontech.de.; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany. ugur.sahin@biontech.de.; Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University Mainz, Mainz, Germany. ugur.sahin@biontech.de.; HI-TRON, Helmholtz Institute for Translational Oncology Mainz - A Helmholtz Institute of the DKFZ, Mainz, Germany. ugur.sahin@biontech.de., Oehm P; BioNTech, Mainz, Germany., Derhovanessian E; BioNTech, Mainz, Germany., Jabulowsky RA; BioNTech, Mainz, Germany., Vormehr M; BioNTech, Mainz, Germany., Gold M; BioNTech, Mainz, Germany., Maurus D; BioNTech, Mainz, Germany., Schwarck-Kokarakis D; BioNTech, Mainz, Germany., Kuhn AN; BioNTech, Mainz, Germany., Omokoko T; BioNTech, Mainz, Germany., Kranz LM; BioNTech, Mainz, Germany., Diken M; BioNTech, Mainz, Germany.; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany., Kreiter S; BioNTech, Mainz, Germany.; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany., Haas H; BioNTech, Mainz, Germany., Attig S; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University Mainz, Mainz, Germany., Rae R; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany., Cuk K; BioNTech, Mainz, Germany., Kemmer-Brück A; BioNTech, Mainz, Germany., Breitkreuz A; BioNTech, Mainz, Germany., Tolliver C; BioNTech, Mainz, Germany., Caspar J; BioNTech, Mainz, Germany., Quinkhardt J; BioNTech, Mainz, Germany., Hebich L; BioNTech, Mainz, Germany., Stein M; BioNTech, Mainz, Germany., Hohberger A; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany., Vogler I; BioNTech, Mainz, Germany., Liebig I; BioNTech, Mainz, Germany., Renken S; BioNTech, Mainz, Germany., Sikorski J; BioNTech, Mainz, Germany., Leierer M; Department of Dermatology and National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany., Müller V; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Mannheim, Germany., Mitzel-Rink H; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Miederer M; Department of Nuclear Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Huber C; BioNTech, Mainz, Germany.; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany., Grabbe S; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Utikal J; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Mannheim, Germany., Pinter A; Department of Dermatology, Venereology and Allergology, University Hospital Frankfurt am Main, Frankfurt am Main, Germany., Kaufmann R; Department of Dermatology, Venereology and Allergology, University Hospital Frankfurt am Main, Frankfurt am Main, Germany., Hassel JC; Department of Dermatology and National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany., Loquai C; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Türeci Ö; BioNTech, Mainz, Germany.; HI-TRON, Helmholtz Institute for Translational Oncology Mainz - A Helmholtz Institute of the DKFZ, Mainz, Germany.

Publikováno v: Nature [Nature] 2020 Sep; Vol. 585 (7823), pp. 107-112. Date of Electronic Publication: 2020 Jul 29.