Experimental capture of miRNA targetomes: disease-specific 3'UTR library-based miRNA targetomics for Parkinson's disease.

Autor: Hart M; Human Genetics, Saarland University, 66421, Homburg, Germany. martin.hart@uks.eu., Kern F; Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Saarland University Campus, Saarbrücken, Germany., Fecher-Trost C; Department of Experimental and Clinical Pharmacology & Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, 66421, Homburg, Germany., Krammes L; Human Genetics, Saarland University, 66421, Homburg, Germany., Aparicio E; Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany., Engel A; Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany., Hirsch P; Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany., Wagner V; Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany., Keller V; Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.; Department for Internal Medicine II, Saarland University Hospital, 66421, Homburg, Germany., Schmartz GP; Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany., Rheinheimer S; Human Genetics, Saarland University, 66421, Homburg, Germany., Diener C; Human Genetics, Saarland University, 66421, Homburg, Germany., Fischer U; Human Genetics, Saarland University, 66421, Homburg, Germany., Mayer J; Human Genetics, Saarland University, 66421, Homburg, Germany., Meyer MR; Department of Experimental and Clinical Pharmacology & Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, 66421, Homburg, Germany., Flockerzi V; Department of Experimental and Clinical Pharmacology & Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, 66421, Homburg, Germany., Keller A; Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Saarland University Campus, Saarbrücken, Germany., Meese E; Human Genetics, Saarland University, 66421, Homburg, Germany.

Publikováno v: Experimental & molecular medicine [Exp Mol Med] 2024 Apr; Vol. 56 (4), pp. 935-945. Date of Electronic Publication: 2024 Apr 01.

mRNA- und miRNA-Expressionsprofile der Bindehaut von Patienten mit kongenitaler Aniridie sind durch den Genotyp und Phänotyp beeinflusst

Autor: Latta, L., Ludwig, N., Krammes, L., Stachon, T., Fries, F.N., Szentmáry, N., Seitz, B., Wowra, B., Mukwaya, A., Kahraman, M., Keller, A., Meese, E., Lagali, N., Käsmann-Kellner, B.

Publikováno v: 92. Versammlung des Vereins Rhein-Mainischer Augenärzte; 20191102-20191102; Darmstadt; DOC19rma05 /20200429/

Hintergrund: Die microRNA- und mRNA Expression von konjunktivalen Zellen bei der Aniridie Assoziierten-Keratopathie (AAK) wurde bei einer Kohorte von Probanden mit angeborener Aniridie untersucht. Anschließend wurden die Ergebnisse in Bezug zu dem b

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http://www.egms.de/en/meetings/rma2019/19rma05.shtml

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Ionizing radiation effects on blood-derived extracellular vesicles: insights into miR-34a-5p-mediated cellular responses and biomarker potential.

Autor: Huber, Chiara¹ (AUTHOR), Elsaeed, Omar¹ (AUTHOR), Lahmer, Pia¹ (AUTHOR), Moertl, Simone¹ (AUTHOR) smoertl@bfs.de

Publikováno v: Cell Communication & Signaling. 10/2/2024, Vol. 22 Issue 1, p1-19. 19p.

Validation of human microRNA target pathways enables evaluation of target prediction tools.

Autor: Kern F; Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany., Krammes L; Institute of Human Genetics, Saarland University, 66421 Homburg, Germany., Danz K; Department of Bioprocessing & Bioanalytics, Fraunhofer Institute for Biomedical Engineering, 66280 Sulzbach, Germany., Diener C; Institute of Human Genetics, Saarland University, 66421 Homburg, Germany., Kehl T; Center for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany., Küchler O; Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany., Fehlmann T; Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany., Kahraman M; Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany., Rheinheimer S; Institute of Human Genetics, Saarland University, 66421 Homburg, Germany., Aparicio-Puerta E; Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.; Department of Genetics, Faculty of Science, University of Granada, 18071 Granada, Spain.; Instituto de Investigación Biosanitaria ibs. Granada, University of Granada, 18071 Granada, Spain., Wagner S; Department of Bioprocessing & Bioanalytics, Fraunhofer Institute for Biomedical Engineering, 66280 Sulzbach, Germany., Ludwig N; Institute of Human Genetics, Saarland University, 66421 Homburg, Germany.; Center of Human and Molecular Biology, Saarland University, 66123 Saarbrücken, Germany., Backes C; Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany., Lenhof HP; Center for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany., von Briesen H; Department of Bioprocessing & Bioanalytics, Fraunhofer Institute for Biomedical Engineering, 66280 Sulzbach, Germany., Hart M; Institute of Human Genetics, Saarland University, 66421 Homburg, Germany., Keller A; Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.; Center for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Meese E; Institute of Human Genetics, Saarland University, 66421 Homburg, Germany.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Jan 11; Vol. 49 (1), pp. 127-144.