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Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks

Autor: Wijk, Lise M. van, Kramer, Claire J. H., Vermeulen, Sylvia, Haar, Natalja T. ter, Jonge, Marthe M. de, Kroep, Judith R., Kroon, Cor D. de, Gaarenstroom, Katja N., Vrieling, Harry, Bosse, Tjalling, Vreeswijk, Maaike P. G.

Publikováno v: Cancers
Volume 13
Issue 12

PARP inhibitor (PARPi) sensitivity is related to tumor-specific defects in homologous recombination (HR). Therefore, there is great clinical interest in tests that can rapidly and reliably identify HR deficiency (HRD). Functional HRD tests determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::e3ce5f519d04fc3252f92c99838b9e60

The intra-tumoral stroma in patients with breast cancer increases with age

Autor: Vangangelt, Kiki M. H., Kramer, Claire J. H., Bastiaannet, Esther, Putter, Hein, Cohen, Danielle, van Pelt, Gabi W., Rakha, Emad A., Green, Andrew R., Tollenaar, Rob A. E. M., Mesker, Wilma E.

Purpose The tumor microenvironment in older patients is subject to changes. The tumor-stroma ratio (TSR) was evaluated in order to estimate the amount of intra-tumoral stroma and to evaluate the prognostic value of the TSR in older patients with brea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::13692aa167c7a1c1c6ed5625c812fb0f

RB Loss in p53 Abnormal Endometrial Carcinoma: Histological and Clinicopathological Correlates.

Autor: Serbes ED; Department of Pathology, Van Research and Training Hospital, Van, Turkiye., Horeweg N; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands., Parra-Herran C; Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., van Rijnsoever R; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Jobsen JJ; Department of Radiation Oncology, Medisch Spectrum Twente, Enschede, The Netherlands., Jurgenliemk-Schulz I; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Kuijsters N; Department of Radiation Oncology, Maastro Clinic, Maastricht, The Netherlands., Nout RA; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands., Haverkort MAD; Department of Radiation Oncology, Radiotherapiegroep, Arnhem, The Netherlands., Powell ME; Department of Clinical Oncology, Barts Health NHS Trust, London, United Kingdom., Khaw P; Department of Radiation Oncology, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia., Plante M; Department of Obstetrics, Gynecology, and Reproduction, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada., Genestie C; Department of Pathology, Gustave Roussy, Villejuif, Île-de-France, France., Nijman HW; Department of Gynecology, University Medical Center Groningen, Groningen, The Netherlands., Creutzberg CL; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands., Bosse T; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: T.Bosse@lumc.nl., Kramer CJH; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2024 Nov 20, pp. 100660. Date of Electronic Publication: 2024 Nov 20.