Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling.

Autor: van Kuijk K; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Demandt JAF; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands., Perales-Patón J; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University, and Heidelberg University Hospital, Bioquant, Heidelberg, Germany.; Joint Research Centre for Computational Biomedicine (JRC COMBINE), Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Theelen TL; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands., Kuppe C; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Marsch E; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands., de Bruijn J; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands., Jin H; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands., Gijbels MJ; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands.; Department of Molecular Genetics, MUMC, Maastricht, Netherlands.; Department of Experimental Vascular Biology, Amsterdam UMC, Amsterdam, The Netherlands.; GROW-School for Oncology and Developmental Biology, MUMC, Maastricht, Netherlands., Matic L; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Mees BME; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Vascular Surgery, MUMC, Maastricht, Netherlands., Reutelingsperger CPM; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Biochemistry, MUMC, Maastricht, Netherlands., Hedin U; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Biessen EAL; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands.; Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany., Carmeliet P; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, VIB Center for Cancer biology, B-3000 Leuven, Belgium., Baker AH; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; BHF Centre for Cardiovascular Sciences (CVS), University of Edinburgh, Edinburgh, UK., Kramann RK; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands., Schurgers LJ; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Department of Biochemistry, MUMC, Maastricht, Netherlands., Saez-Rodriguez J; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University, and Heidelberg University Hospital, Bioquant, Heidelberg, Germany.; Joint Research Centre for Computational Biomedicine (JRC COMBINE), Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Sluimer JC; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, Netherlands.; Department of Pathology, MUMC, P. Debyelaan 25, 6229HX Maastricht, Netherlands.; BHF Centre for Cardiovascular Sciences (CVS), University of Edinburgh, Edinburgh, UK.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2022 Mar 25; Vol. 118 (5), pp. 1232-1246.