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Enhanced cell-induced articular cartilage regeneration by chondrons; the influence of joint damage and harvest site

Autor: Vonk, L A, de Windt, T S, Kragten, A H M, Beekhuizen, M, Mastbergen, S C, Dhert, W J A, Lafeber, F P J G, Creemers, L B, Saris, D B F, Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, CSCA TR1, Tissue Repair

Publikováno v: Osteoarthritis and cartilage, 22(11), 1910-1917. W.B. Saunders Ltd
Osteoarthritis and Cartilage, 22(11), 1910. W.B. Saunders Ltd

OBJECTIVE: Interactions between chondrocytes and their native pericellular matrix provide optimal circumstances for regeneration of cartilage. However, cartilage diseases such as osteoarthritis change the pericellular matrix, causing doubt to them as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4b1ce3dd4bd1c009380cb2a69cf195
https://doi.org/10.1016/j.joca.2014.08.005

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Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells

Autor: Yang, Hsiao-yin, Vonk, Lucienne A, Licht, Ruud, van Boxtel, Antonetta M G, Bekkers, Joris E J, Kragten, Angela H M, Hein, San, Varghese, Oommen P, Howard, Kenneth A, Öner, F Cumhur, Dhert, Wouter J A, Creemers, Laura B, Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, Tissue Repair, CSCA TR1

Publikováno v: European Journal of Pharmaceutical Sciences, 53, 35. Elsevier
Yang, H Y, Vonk, L A, Licht, R, Van Boxtel, A M G, Bekkers, J E J, Kragten, A H M, Hein, S, Varghese, O P, Howard, K, Cumhur Öner, F, Dhert, W J A & Creemers, L B 2014, ' Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells ', European Journal of Pharmaceutical Sciences, vol. 53, no. 1, pp. 35-44 . https://doi.org/10.1016/j.ejps.2013.12.006

The application of RNA interference (RNAi) has great therapeutic potential for degenerative diseases of cartilaginous tissues by means of fine tuning the phenotype of cells used for regeneration. However, possible non-specific effects of transfection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ae9d305c5ccd628c70b25297320e0e
https://dspace.library.uu.nl/handle/1874/314333