The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size.

Autor: Fuchs K; Department of Immunology, University of Tübingen, Tübingen, Germany., Cardona Gloria Y; Department of Immunology, University of Tübingen, Tübingen, Germany., Wolz OO; Department of Immunology, University of Tübingen, Tübingen, Germany., Herster F; Department of Immunology, University of Tübingen, Tübingen, Germany., Sharma L; Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Microbial Pathogenesis, Center for Pulmonary Infection Research and Infection (CPIRT), New Haven, CT, USA., Dillen CA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Täumer C; Department of Quantitative Proteomics and Proteome Center, University of Tübingen, Tübingen, Germany., Dickhöfer S; Department of Immunology, University of Tübingen, Tübingen, Germany., Bittner Z; Department of Immunology, University of Tübingen, Tübingen, Germany., Dang TM; Department of Immunology, University of Tübingen, Tübingen, Germany., Singh A; University Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen, Tübingen, Germany., Haischer D; Center for Plant Molecular Biology, University of Tübingen, Tübingen, Germany., Schlöffel MA; Center for Plant Molecular Biology, University of Tübingen, Tübingen, Germany., Koymans KJ; Department of Medical Microbiology, University Medical Center Utrecht, CX Utrecht, The Netherlands., Sanmuganantham T; Department of Immunology, University of Tübingen, Tübingen, Germany., Krach M; Department of Immunology, University of Tübingen, Tübingen, Germany., Roger T; Infectious Diseases Service, Lausanne University Hospital, Epalinges, Switzerland., Le Roy D; Infectious Diseases Service, Lausanne University Hospital, Epalinges, Switzerland., Schilling NA; Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany., Frauhammer F; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Dermatology, Heidelberg University, Heidelberg, Germany., Miller LS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Nürnberger T; Center for Plant Molecular Biology, University of Tübingen, Tübingen, Germany., LeibundGut-Landmann S; Section of Immunology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland., Gust AA; Center for Plant Molecular Biology, University of Tübingen, Tübingen, Germany., Macek B; Department of Quantitative Proteomics and Proteome Center, University of Tübingen, Tübingen, Germany., Frank M; Biognos AB, Göteborg, Sweden., Gouttefangeas C; Department of Immunology, University of Tübingen, Tübingen, Germany., Dela Cruz CS; Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Microbial Pathogenesis, Center for Pulmonary Infection Research and Infection (CPIRT), New Haven, CT, USA., Hartl D; University Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen, Tübingen, Germany.; Roche Pharma Research & Early Development (pRED), Immunology, Inflammation and Infectious Diseases (I3) Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland., Weber AN; Department of Immunology, University of Tübingen, Tübingen, Germany alexander.weber@uni-tuebingen.de.

Publikováno v: EMBO reports [EMBO Rep] 2018 Dec; Vol. 19 (12). Date of Electronic Publication: 2018 Oct 18.