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Modular kinetic analysis reveals differences in Cd2+ and Cu2+ ion-induced impairment of oxidative phosphorylation in liver

Autor: Ciapaite, J., Nauciene, Z., Baniene, R., Wagner, M.J., Krab, K., Mildaziene, V.

Publikováno v: Ciapaite, J, Nauciene, Z, Baniene, R, Wagner, M J, Krab, K & Mildaziene, V 2009, ' Modular kinetic analysis reveals differences in Cd2+ and Cu2+ ion-induced impairment of oxidative phosphorylation in liver. ', The FEBS Journal, vol. 276, pp. 3656-3668 . https://doi.org/10.1111/j.1742-4658.2009.07084.x
The FEBS Journal, 276, 3656-3668. Wiley-Blackwell

Impaired mitochondrial function contributes to copper- and cadmium-induced cellular dysfunction. In this study, we used modular kinetic analysis and metabolic control analysis to assess how Cd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::00aa564e822f8ec97afb47fddfaae22d
https://hdl.handle.net/1871.1/7497bab1-f2ec-40f8-9af4-118fc662a529

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Application of modular control analysis to inhibition of the adenine nucleotide translocator by palmitoyl-CoA

Autor: Ciapaite, J., van Eikenhorst, G., Krab, K.

Publikováno v: Molecular Biology Reports, 29, 13-16. Springer Netherlands
Ciapaite, J, van Eikenhorst, G & Krab, K 2002, ' Application of modular control analysis to inhibition of the adenine nucleotide translocator by palmitoyl-CoA. ', Molecular Biology Reports, vol. 29, pp. 13-16 . https://doi.org/10.1023/A:1020385714555

Modular kinetic analysis was used to characterize inhibition of adenine nucleotide translocation by palmitoyl-CoA in isolated rat-liver mitochondria. To this purpose, oxidative phosphorylation has been divided into two modules with the fraction of ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cd59ad6d61a9478d5dc4b8e0a6193966
https://hdl.handle.net/1871.1/d0322464-a83d-4ad7-8434-87e60f3fcc7f

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Identification of the site where the electron transfer chain of plant mitochondria is stimulated by electrostatic charge screening

Autor: Krab, K., Wagner, M.J., Wagner, A.M., Moller, I.M.

Publikováno v: European Journal of Biochemistry, 267, 869-876. Wiley-Blackwell
Krab, K, Wagner, M J, Wagner, A M & Moller, I M 2000, ' Identification of the site where the electron transfer chain of plant mitochondria is stimulated by electrostatic charge screening. ', European Journal of Biochemistry, vol. 267, pp. 869-876 . https://doi.org/10.1046/j.1432-1327.2000.01065.x

Modular kinetic analysis was used to determine the sites in plant mitochondria where charge-screening stimulates the rate of electron transfer from external NAD(P)H to oxygen. In mitochondria isolated from potato (Solanum tuberosum L.) tuber callus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c5781f63f1464a107c6afb059c575a42
https://doi.org/10.1046/j.1432-1327.2000.01065.x

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The reduction state of the Q-pool regulates the electron flux through the branched respiratory network of Paracoccus denitrificans

Autor: Otten, M F, Reijnders, W N, Bedaux, J J, Westerhoff, H V, Krab, K, Van Spanning, R J

Publikováno v: Otten, M F, Reijnders, W N, Bedaux, J J, Westerhoff, H V, Krab, K & Van Spanning, R J 1999, ' The reduction state of the Q-pool regulates the electron flux through the branched respiratory network of Paracoccus denitrificans ', European Journal of Biochemistry, vol. 261, no. 3, pp. 767-74 . https://doi.org/10.1046/j.1432-1327.1999.00334.x
European Journal of Biochemistry, 261(3), 767-74. Wiley-Blackwell

In this work we demonstrate how the reduction state of the Q-pool determines the distribution of electron flow over the two quinol-oxidising branches in Paracoccus denitrificans: one to quinol oxidase, the other via the cytochrome bc1 complex to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c62cc37bb468154dd88c3027c12068cb
https://doi.org/10.1046/j.1432-1327.1999.00334.x

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Het kleinste leven als bron van grote ontwikkelingen in de biologie: Naar een wiskundig model voor de cel

Autor: Krab, K.

Publikováno v: Krab, K 2011, Het kleinste leven als bron van grote ontwikkelingen in de biologie: Naar een wiskundig model voor de cel. in De Wetenschappelijke Biobliotheek, Natuurwetenschap en Techniek. (ed.), Microcanon; wat je beslist moet weten over microbiologie. . Veen Magazines, Diemen, pp. 213-214 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4db0748fa6a37897ee822bf42d6c85f3
https://research.vu.nl/en/publications/1d764121-9e42-4d63-94cc-f81444716e97

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Explaining the enigmatic Km for oxygen in cytochrome c oxidase

Autor: Krab, K., Kempe, H., Wikstrom, M.

Publikováno v: Krab, K, Kempe, H & Wikstrom, M 2011, ' Explaining the enigmatic Km for oxygen in cytochrome c oxidase. ', Biochimica et Biophysica Acta (BBA)-Bioenergetics, vol. 1807, pp. 348-358 . https://doi.org/10.1016/j.bbabio.2010.12.015
Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1807, 348-358. Elsevier

We present a mathematical model for the functioning of proton-pumping cytochrome c oxidase, consisting of cyclic conversions between 26 enzyme states. The model is based on the mechanism of oxygen reduction and linked proton translocation postulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0424b8cdf211a38f4b7cf4ed323b4174
https://research.vu.nl/en/publications/bcd2ff22-561e-4a05-b863-47c852919929

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Modular kinetic analysis

Autor: Krab, K., Jameson, D., Verma, M., Westerhoff, H.V.

Publikováno v: Methods in Enzymology, 555-570
STARTPAGE=555;ENDPAGE=570;TITLE=Methods in Enzymology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::c2f0b38952f8e70f7d2b5cea7e6abde8
https://research.vu.nl/en/publications/73f18200-be3f-4c42-ac09-fbc53c4eb7ef

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AmtB-mediated NH(3) transport in prokaryotes must be active and as a consequence regulation of transport by GlnK is mandatory to limit futile cycling of NH(4)(+)/NH(3)

Autor: Boogerd, F.C., Ma, Huiye, Bruggeman, Frank, Heeswijk, Wally, Garcia-Contreras, R., Molenaar, D., Krab, K., Westerhoff, Hans

Publikováno v: FEBS Letters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::24e9e033cee81a525ae814cde187043e
https://ir.cwi.nl/pub/17868

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Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations

Autor: Hardin, H.M., Zagaris, A., Krab, K., Westerhoff, H.V.

Publikováno v: The FEBS Journal, 276(19), 5491-5506. Wiley-Blackwell
The FEBS Journal, 276, 5491-5506. Wiley-Blackwell
Hardin, H M, Zagaris, A, Krab, K & Westerhoff, H V 2009, ' Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations. ', The FEBS Journal, vol. 276, pp. 5491-5506 . https://doi.org/10.1111/j.1742-4658.2009.07233.x

Much of enzyme kinetics builds on simplifications enabled by the quasi-steady-state approximation and is highly useful when the concentration of the enzyme is much lower than that of its substrate. However, in vivo, this condition is often violated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8f781d04062f3baea760e4708e6ad069
https://dare.uva.nl/personal/pure/en/publications/simplified-yet-highly-accurate-enzyme-kinetics-for-cases-of-low-substrate-concentrations(df417fd7-7665-42b2-b44c-b82454368763).html

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