Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kr��ger, Christina"'
Autor:
Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija
Additional file 3. Gene Ontology (GO) enrichment analysis of biological processes for miRNAs that are enriched in supernatant of apoptotic cortical neurons. Color refers to significance (FDR, false discovery rate), while size indicates the correspond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc6d594526d4efbe3385c2a837b6921
Autor:
Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija
Additional file 11. Intrathecal pre-treatment with LPS enhances miR-298-5p- and miR-100-5p-induced neurodegeneration and microglial accumulation. 1 ��g LPS was injected intrathecally into C57BL/6 mice. After 16 h, mice were injected intrathecally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153c067774c36730f609ca6da6d328da
Autor:
Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija
Additional file 5. Low dose response of miR-100-5p- and miR-298-5p-treated microglia and HEK293 hTLR7/8 reporter cells. (a) Images of C57BL/6 microglia incubated with 5 ��g/ml of miR-100-5p or miR-298-5p, or PBS (control) for 4 h. Subsequently, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32975c397391794acb70cb4d64b58ab5
Autor:
Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija
Additional file 9. miR-298-5p and miR-100-5p enter neurons and co-localize to their endosomal compartment and TLR7. (a) Enriched C57BL/6 cortical neurons were incubated with 40 ��g/ml pHrodo Red Dextran serving as endosomal marker for 20 min. Sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94896969b49952bbafa2751a8a4c13e3
Autor:
Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija
Additional file 13: Table S2. miRNA concentrations used in this study given in [nm].
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781a845cb608ad6b52a4e8b70ce02a02
Autor:
Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija
Additional file 6. Extracellular miR-100-5p and miR-298-5p increase microglial phagocytic activity. Microglia from C57BL/6 mice were exposed to 5 ��g/ml of the indicated miRNAs, LPS (100 ng/ml), or solvent control (PBS). After 2 h, microglia were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298851eeb2dca6fcc648634e3d8c33a2
Autor:
Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija
Additional file 7. Microscale thermophoresis measurement of let-7g-5p and specificity control. Binding affinity measurements of the purified polyhistidine-tagged human TLR8 protein and (a) let-7g-5p and (b) miR-298-5p using microscale thermophoresis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e224890c809d3f85d2690d8e4f2997b
Autor:
Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija
Additional file 8. let-7g-5p and miR-672-5p induce neuronal injury in vitro. (a, b) Co-cultures of C57BL/6 (wild-type, WT) microglia and neurons were incubated with 5 ��g/ml of indicated miRNAs for 5 d. Mutant control oligonucleotide and unstimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d193d31cac67648739ce2d1c54c0bb48
Autor:
Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija
Additional file 10. Intrathecal brain-derived, small RNA triggers neurodegeneration. 125 pmol of an LNA inhibitor specific for mmu-miR-298-5p (miR-298-I), an LNA negative control inhibitor (neg. co.-I), or solvent (H2O) were injected intrathecally in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd402fcbd2b5ca12b800acabd8125c3
Autor:
Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija
Additional file 1. Quality control parameter after normalization for mouse probes of the GeneChip miRNA array. Density histograms of probe intensities (a) and principal components analysis (b) for apoptotic cortical neurons and corresponding neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c17ff043484e481a1345c3aab1c98e