Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters

Autor: Kracht, Matthias, van den Boom, Johannes, Seiler, Jonas, Kröning, Alexander, Kaschani, Farnusch, Kaiser, Markus, Meyer, Hemmo

Publikováno v: In Journal of Molecular Biology 20 November 2020 432(23):6061-6074

The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase

Autor: Blüggel, Mike, Kröning, Alexander, Kracht, Matthias, van den Boom, Johannes, Dabisch, Matthias, Göhring, Anna, Kaschani, Farnusch, Kaiser, Markus, Bayer, Peter, Meyer, Hemmo, Beuck, Christine

The AAA+ ATPase p97/VCP together with different sets of substrate-delivery adapters and accessory cofactor proteins unfolds ubiquitinated substrates to facilitate degradation by the proteasome. The UBXD1 cofactor is connected to p97-associated multis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=unidue___bib::c1558e1e828f589bd24688475f374261
https://www.ncbi.nlm.nih.gov/pubmed/37277335

Author Correction: Aberrant methylated key genes of methyl group metabolism within the molecular etiology of urothelial carcinogenesis.

Autor: Erichsen L; Epigenetics Core Laboratory, Institute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany., Ghanjati F; Epigenetics Core Laboratory, Institute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany., Beermann A; Epigenetics Core Laboratory, Institute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany., Poyet C; Department of Urology, University Hospital, University of Zurich, Zurich, Switzerland., Hermanns T; Department of Urology, University Hospital, University of Zurich, Zurich, Switzerland., Schulz WA; Department of Urology, Medical Faculty, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany., Seifert HH; Urologische Klinik, Universitätsspital Basel, Basel, Switzerland., Wild PJ; Institute of Surgical Pathology, University Hospital, University of Zurich, 8091, Zurich, Switzerland., Buser L; Institute of Surgical Pathology, University Hospital, University of Zurich, 8091, Zurich, Switzerland., Kröning A; Epigenetics Core Laboratory, Institute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany., Braunstein S; Department of Pathology, Medical Faculty, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany., Anlauf M; Department of Pathology, Medical Faculty, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany., Jankowiak S; Department of Pathology, Medical Faculty, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany., Hassan M; Department of Surgery, Tulane University School of Medicine, New Orleans, LA, 70112, USA.; Institut National de la Santé et de la Recherché Médicale, University of Strasbourg, 67000, Strasbourg, France., Bendhack ML; Department of Urology, University Hospital, Positivo University, Curitiba, Brazil., Araúzo-Bravo MJ; Group of Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, 20014, San Sebastián, Spain.; IKERBASQUE, Basque Foundation for Science, 48009, Bilbao, Spain., Santourlidis S; Epigenetics Core Laboratory, Institute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany. simeon.santourlidis@med.uni-duesseldorf.de.

Publikováno v: Scientific reports [Sci Rep] 2018 Apr 11; Vol. 8 (1), pp. 6051. Date of Electronic Publication: 2018 Apr 11.