Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kozo Shimakawa"'
Autor:
Ritsuko Esaki, Yoshitaka Yasuhara, Kozo Shimakawa, Mitsugu Nakata, Koji Takeuchi, Kimihiko Iwachidow, Takashi Yano, Kae Nagasumi, Hiroyuki Odaka, Kazuhiro Ogi, Shigehisa Taketomi, Yoshihiko Kaisho, Hideyuki Tanaka
Publikováno v:
Diabetes. 58:1067-1076
OBJECTIVE GPR40 is a G protein–coupled receptor regulating free fatty acid–induced insulin secretion. We generated transgenic mice overexpressing the hGPR40 gene under control of the mouse insulin II promoter and used them to examine the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::928c3627d4efbcafed903bce009245d8
https://doi.org/10.2337/db08-1233
https://doi.org/10.2337/db08-1233
Autor:
Yoshio Taniyama, Yoshitaka Yasuhara, Tomoko Satomi, Kozo Shimakawa, Hiromitsu Fuse, Mitsugu Nakata, Sachio Shibata, Shigehisa Taketomi, Masahiko Hattori, Ryuichi Tozawa
Publikováno v:
Biochemical and Biophysical Research Communications. 330:104-110
Human LCAT-like lysophospholipase (LLPL), or lysophospholipase 3, was first identified in vitro, in foam cells derived from THP-1 cells. We demonstrated that LLPL was present in foam cells in the severe atherosclerotic lesions that develop in apolipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73642b58197d7eea3edc2252288381d
https://doi.org/10.1016/j.bbrc.2005.02.126
https://doi.org/10.1016/j.bbrc.2005.02.126
Autor:
Yoshiko Kishimoto, Kumiko Kogishi, Yoshiaki Omori, Masanori Hosokawa, Eishi Deguchi, Toshio Abe, Keiichi Higuchi, Toshio Takeda, Kuraichi Yasuoka, Takatoshi Matsushita, Kozo Shimakawa
Publikováno v:
Experimental Gerontology. 32:111-116
The Senescence-Accelerated Mouse (SAM) was established by inbreeding and pedigree selection based on the life span, degree of senescence, as well as the incidence and degree of several age-associated disorders. At first, SAM strains were developed un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db46e53110ea57bcd7dcd05dd61ddbb
https://doi.org/10.1016/s0531-5565(96)00078-2
https://doi.org/10.1016/s0531-5565(96)00078-2
Autor:
Hideki Matsui, Yoshitaka Yasuhara, Takashi Yano, Kozo Shimakawa, Yoshihiko Kaisho, Takuya Watanabe, Mitsugu Nakata, Shigehisa Taketomi, Yasuko Terao, Yasufumi Sakura, Ikuo Mori
Publikováno v:
Biochemical and biophysical research communications. 330(3)
The human MrgX3 gene, belonging to the mrgs/SNSRs (mas related genes/sensory neuron specific receptors) family, was overexpressed in transgenic rats using the actin promoter. Two animal lines showed cataracts with liquification/degeneration and swell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f852adf51b86fd2b86dda95da85d979
https://pubmed.ncbi.nlm.nih.gov/15809047
https://pubmed.ncbi.nlm.nih.gov/15809047
Autor:
Kunio Matsuoka, Tatsuo Suda, Toshimasa Shinki, Shigehisa Taketomi, Naobumi Hosogane, Yasufumi Sakura, Kozo Shimakawa, Hisao Kasuga, Ikuo Mori
Publikováno v:
Biochemical and biophysical research communications. 297(5)
Vitamin D-24-hydroxylase (CYP24) is one of the enzymes responsible for vitamin D metabolism. CYP24 catalyzes the conversion of 25-hydroxyvitamin D(3) [25(OH)D(3)] to 24,25-dihydroxyvitamin D(3) [24,25(OH)(2)D(3)] in the kidney. CYP24 is also involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e20758c3b3d9eeff005d1f6afde1bba
https://pubmed.ncbi.nlm.nih.gov/12372434
https://pubmed.ncbi.nlm.nih.gov/12372434
Publikováno v:
The Journal of Nutrition. 113:1784-1790
Male weanling rats, fed a riboflavin-deficient diet for 14 days showed impairments in reactivity to the hyperphagic action of either insulin or 2-deoxy-D-glucose (2DG) and in sensitivity to the diabetogenic action of streptozotocin or alloxan. The in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ee47f39d04fab24634254f3c7081a4
https://doi.org/10.1093/jn/113.9.1784
https://doi.org/10.1093/jn/113.9.1784
Publikováno v:
Japanese Journal of Pharmacology. 32:839-844
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57aac99d31ab7268cfa032e413a193c3
https://doi.org/10.1016/s0021-5198(19)52620-8
https://doi.org/10.1016/s0021-5198(19)52620-8
Publikováno v:
Journal of Nutritional Science and Vitaminology. 30:255-264
Self-selection from carbohydrate, protein and fat sources including essential micronutrients was studied in male Sprague-Dawley rats that were 4 weeks of age at the beginning of the experiment. During the experimental period of 14 days, the intake of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f43a894fe4dfa64033743f3c8ce57b9
https://doi.org/10.3177/jnsv.30.255
https://doi.org/10.3177/jnsv.30.255
Publikováno v:
Journal of Nutritional Science and Vitaminology. 30:265-272
Adult male fatty and lean rats of Zucker strain were given access ad libitum to either a single nutritionally complete diet, or a self-selection regime with separate sources of three macronutrients, protein (casein), fat (hydrogenated coconut oil), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1cd7ec04918c495cf8aa94f75dcd86
https://doi.org/10.3177/jnsv.30.265
https://doi.org/10.3177/jnsv.30.265
Publikováno v:
European journal of pharmacology. 125(2)
The antiobesity effects of (S)-(+)-1-(4-chlorophenylthiomethyl)-N-methylethylamine fumarate (AO-124) were examined in rats and dogs. AO-124 suppressed food intake dose dependently in normal, Zucker fatty and VMH-obese rats, and beagle dogs. Its anore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f90be5d9bd283a667ca1fb41fe12104
https://pubmed.ncbi.nlm.nih.gov/3743636
https://pubmed.ncbi.nlm.nih.gov/3743636