Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kozo Kayano"'
Publikováno v:
Liver. 17:107-114
We examined the effect of cyclosporin A (CsA) on the pathogenesis of acute experimental liver injury in rats induced by injection of heat-killed Propionibacterium acnes (P. acnes) and subsequent injection of lipopolysaccharide (LPS). Pretreatment wit
Publikováno v:
Liver. 15:253-259
Activated liver macrophages are considered to play an important role in the development of liver injuries. Functional differences between activated and normal rat liver macrophages were investigated. In addition, from the therapeutic point of view, t
Publikováno v:
Hepatology Research. 24:282-289
Patients with hepatitis C virus (HCV) related-liver cirrhosis (LC) often develop hepatoma. The type 1 helper T cell (Th1) response presents an antitumor effect. We evaluated the Th1 response in patients with HCV-related LC at the single-cell level an
Publikováno v:
Journal of Gastroenterology. 36:322-329
Alterations in the kinetics of hepatic stellate cells (HSCs) after the cells are activated once have not been well documented. We investigated the characteristic profiles of cell proliferation of once-activated HSCs in contrast to the in fibrogenesis
Publikováno v:
Digestive Diseases and Sciences. 45:1996-2001
The aim of the study was to investigate the effect of the immunosuppressant FK 506 (tacrolimus hydrate) on acute liver injury induced by Propionibacterium acnes and lipopolysaccharide (LPS). Acute liver injury was induced in male Wistar rats by injec
Publikováno v:
Hepatology. 28:1247-1252
Injection of pig serum into rats twice a week for 8 weeks induced stellate cell activation resulting in liver fibrosis without parenchymal cell injury. Administration of a choline deficient L-amino acid defined (CDAA) diet for 6 weeks with or without
Publikováno v:
Journal of Hepatology. 29:642-649
It is of extreme importance to prevent liver fibrosis and subsequent progression to liver cirrhosis. The aim of our study was to elucidate in vitro whether Sho-saiko-to exerted inhibitory effects on hepatic stellate cells.Hepatic stellate cells were
Publikováno v:
Hepatology Research. 12:59-67
The aim of this study was to investigate the effect of interferons- γ (IFN- γ ) and - α (IFN- α ) on the synthesis of matrix proteins such as collagens as well as the gene expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in vivo. We
Publikováno v:
Scandinavian Journal of Gastroenterology. 30:61-67
Recent data indicate that iron ions play a major role in lipid peroxidation, a hepatotoxic effect of acetaminophen (APAP).We investigated whether an iron chelator, deferoxamine (DFO), can protect against APAP-induced liver injury in vivo in rats.DFO
Autor:
Kazutoshi Sanuki, Hiroyuki Shirasawa, Kenji Mori, Kiwamu Okita, Masahumi Kubota, Keisuke Hino, Mitsuru Yasunaga, Michiair Okuda, Fukumoto Y, Kozo Kayano, Kazuyuki Takenaka, Isao Sakaida, Aogu Yamashita, Satoyoshi Yamashita
Publikováno v:
Kanzo. 33:213-218