Vaccine-induced ADCC-mediating antibodies target unique and overlapping envelope epitopes

Autor: Pollara J, Bonsignori M, Moody M, Alam M, Liao H, Hwang K, Pickeral J, Kappes J, Ochsenbauer C, Soderberg K, Gurley TC, Kozink DM, Marshall DJ, Whitesides JF, Montefiori D, Robinson JE, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Kim J, Michael N, Tomaras G, Haynes BF, Ferrari G

Publikováno v: Retrovirology, Vol 9, Iss Suppl 2, p O39 (2012)

Externí odkaz: https://doaj.org/article/7024d914590f46718f49455fb8a7c333

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HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities.

Autor: Pollara J; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Bonsignori M; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Moody MA; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA., Liu P; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA., Alam SM; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA., Hwang KK; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA., Gurley TC; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA., Kozink DM; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA., Armand LC; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA., Marshall DJ; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA., Whitesides JF; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Kaewkungwal J; Center of Excellence for Biomedical and Public Health Informatics BIOPHICS, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Nitayaphan S; Department of Retrovirology, U.S. Army Medical Component, AFRIMS, Bangkok, Thailand., Pitisuttithum P; Clinical Tropical Medicine, Mahidol University, Bangkok, Thailand., Rerks-Ngarm S; Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand., Robb ML; U.S. Military HIV Research Program, Bethesda, Maryland, USA., O'Connell RJ; Department of Retrovirology, U.S. Army Medical Component, AFRIMS, Bangkok, Thailand., Kim JH; U.S. Military HIV Research Program, Bethesda, Maryland, USA., Michael NL; U.S. Military HIV Research Program, Bethesda, Maryland, USA., Montefiori DC; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Tomaras GD; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA., Liao HX; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Haynes BF; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA., Ferrari G; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA gflmp@duke.edu.

Publikováno v: Journal of virology [J Virol] 2014 Jul; Vol. 88 (14), pp. 7715-26. Date of Electronic Publication: 2014 May 07.

IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.

Autor: Hwang KK; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Trama AM; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Kozink DM; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Chen X; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Wiehe K; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Cooper AJ; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Xia SM; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Wang M; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Marshall DJ; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Whitesides J; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Alam M; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Tomaras GD; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Allen SL; The Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America., Rai KR; The Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America., McKeating J; School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom., Catera R; The Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America., Yan XJ; The Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America., Chu CC; The Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America., Kelsoe G; Department of Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America., Liao HX; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America., Chiorazzi N; The Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America., Haynes BF; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America.

Publikováno v: PloS one [PLoS One] 2014 Mar 10; Vol. 9 (3), pp. e90725. Date of Electronic Publication: 2014 Mar 10 (Print Publication: 2014).

Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Autor: Liao HX; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA. hliao@duke.edu, Bonsignori M, Alam SM, McLellan JS, Tomaras GD, Moody MA, Kozink DM, Hwang KK, Chen X, Tsao CY, Liu P, Lu X, Parks RJ, Montefiori DC, Ferrari G, Pollara J, Rao M, Peachman KK, Santra S, Letvin NL, Karasavvas N, Yang ZY, Dai K, Pancera M, Gorman J, Wiehe K, Nicely NI, Rerks-Ngarm S, Nitayaphan S, Kaewkungwal J, Pitisuttithum P, Tartaglia J, Sinangil F, Kim JH, Michael NL, Kepler TB, Kwong PD, Mascola JR, Nabel GJ, Pinter A, Zolla-Pazner S, Haynes BF

Publikováno v: Immunity [Immunity] 2013 Jan 24; Vol. 38 (1), pp. 176-86. Date of Electronic Publication: 2013 Jan 11.