Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Koyu Hoshino"'
Autor:
Koyu Hoshino, Norio Asou, Ken Ichi Iyama, Hiroaki Mitsuya, Sonoko Ishihara, Tatsuya Kawaguchi, Rie Yamada, Kentaro Horikawa
Publikováno v:
International Journal of Hematology. 91:711-715
While anti-cancer chemotherapy has improved the survival of patients with hematologic malignancies, it has also exposed such patients to the risk of life-threatening infection due to neutropenia. In intensive chemotherapy for leukemia, invasive asper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d17329847369a44270c192a8b773674
https://doi.org/10.1007/s12185-010-0556-2
https://doi.org/10.1007/s12185-010-0556-2
Autor:
Gary L. Rosner, Tapan M. Kadia, Lianchun Xiao, Sherry Pierce, Susan O'Brien, Elias Jabbour, Deborah A. Thomas, Guillermo Garcia-Manero, Hui Yang, Koyu Hoshino, Carlos E. Bueso-Ramos, Hagop M. Kantarjian
Publikováno v:
Blood. 113:1892-1898
Pretreatment aberrant DNA methylation patterns are stable at time of relapse in acute lymphocytic leukemia (ALL). We hypothesized that the detection of residual methylation alterations at the time of morphologic remission may predict for worse progno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6755b526a8f1d34951bcef194f6dda31
https://doi.org/10.1182/blood-2008-02-141002
https://doi.org/10.1182/blood-2008-02-141002
Autor:
Kisato Nosaka, Norio Asou, Hirosada Miyake, Hiroyuki Hata, Hiroaki Mitsuya, Koyu Hoshino, Hiro Tatetsu, Kentaro Horikawa, Noritaka Takatsu, Fumihiko Matsuno
Publikováno v:
Leukemia Research. 33:197-200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3042625fa65d55aef1ea266ebdd544e1
https://doi.org/10.1016/j.leukres.2008.04.002
https://doi.org/10.1016/j.leukres.2008.04.002
Publikováno v:
Leukemia. 21:906-911
Hck and Lyn are required in Philadelphia chromosome (Ph) positive acute lymphocytic leukemia (ALL). Here, we present evidence that the promoter CpG island of Hck, but not of Lyn, is aberrantly methylated in leukemia. Hck promoter DNA methylation was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c06f6aacb4557592562045e81e211c3
https://doi.org/10.1038/sj.leu.2404615
https://doi.org/10.1038/sj.leu.2404615
Publikováno v:
The Journal of Pathology. 212:402-410
Chronic myeloid leukaemia (CML) is characterized by t(9;22)(q34;q11) and the aberrant expression of the fusion protein Bcr-Abl that leads to constitutive activation of c-Abl kinase. Bcr-Abl plays a major role in the development and progression of CML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e38e0995da7579f3ba1e2099f998327
https://doi.org/10.1002/path.2178
https://doi.org/10.1002/path.2178
Autor:
Guillermo Garcia-Manero, Blanca Sanchez-Gonzalez, Hui Yang, Sherry Pierce, Sima Jeha, Hagop M. Kantarjian, Mark Brandt, Andreia A. Canalli, Koyu Hoshino, Jean Pierre J. Issa
Publikováno v:
Leukemia Research. 29:881-885
Aberrant DNA methylation of multiple promoter associated CpG islands is a frequent phenomenon in acute lymphocytic leukemia (ALL). Recently, methylation of a cell cycle control pathway composed of P73, P15 and P57KIP2 has been shown to confer poor pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3787a388c435c0ca074f3bd4488352b4
https://doi.org/10.1016/j.leukres.2004.11.023
https://doi.org/10.1016/j.leukres.2004.11.023
Autor:
Toshiro Kawakita, Hitoshi Suzushima, Tomoko Nanri, Naofumi Matsuno, Koyu Hoshino, Fumio Kawano, Norio Asou, Hiroaki Mitsuya
Publikováno v:
Leukemia Research. 29:557-564
Cyclin-dependent kinase inhibitor p15 is frequently inactivated by either methylation or deletion in patients with acute leukemia. To examine pathologic and clinical significance of the p15 gene inactivation, we established a quantitative assay of p1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ff8b8215a9ef5d34b90eb7d3b9e00a
https://doi.org/10.1016/j.leukres.2004.11.003
https://doi.org/10.1016/j.leukres.2004.11.003
Autor:
Tetsuyuki Kiyokawa, Norio Asou, Fumio Kawano, Koyu Hoshino, Hiroaki Mitsuya, Toshiya Okubo, Hitoshi Suzushima
Publikováno v:
British Journal of Haematology. 117:531-540
Summary. We examined deletion and methylation of the p15INK4B(p15) and p16INK4A(p16) genes, using Southern blotting and methylation-specific polymerase chain reaction (PCR), in 70 untreated adult patients with precursor B-cell acute lymphoblastic leu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8843293d9a7ec91f602f82ed7fde8985
https://doi.org/10.1046/j.1365-2141.2002.03451.x
https://doi.org/10.1046/j.1365-2141.2002.03451.x
Autor:
Essam Abdalla, Katsuya Shigesada, Yoshiaki Ito, Koyu Hoshino, Kiyoshi Takatsuki, Tomohiko Kanno, Motomi Osato, Norio Asou, Hitoshi Suzushima, Toshiya Okubo, Hiroshi Yamasaki
Publikováno v:
Blood. 93:1817-1824
The AML1 gene encoding the DNA-binding -subunit in the Runt domain family of heterodimeric transcription factors has been noted for its frequent involvement in chromosomal translocations associated with leukemia. Using reverse transcriptase-polyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a10e721d90aca9ba2ac150b876490753
https://doi.org/10.1182/blood.v93.6.1817.406k36_1817_1824
https://doi.org/10.1182/blood.v93.6.1817.406k36_1817_1824
Autor:
Hiroshi Yamasaki, Koyu Hoshino, Norio Asou, Toshiya Okubo, Kiyoshi Takatsuki, Shintaro Nishimura, Motomi Osato, Takumi Era, Hitoshi Suzushima
Publikováno v:
Leukemia & Lymphoma. 31:81-91
As recurrent chromosome abnormalities in leukemia are highly associated with particular subtypes, the genetic events of specific chromosome alteration must be associated with leukemogenesis and characteristics of the disease. The chromosomal breakpoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21656971c0a8950408becb94339120cc
https://doi.org/10.3109/10428199809057587
https://doi.org/10.3109/10428199809057587