Crowdsourced mapping of unexplored target space of kinase inhibitors

Autor: Cichońska, A., Ravikumar, B., Allaway, R., Wan, F., Park, S., Isayev, O., Li, S., Mason, M., Lamb, A., Tanoli, Z., Jeon, M., Kim, S., Popova, M., Capuzzi, S., Zeng, J., Dang, K., Koytiger, G., Kang, J., Wells, C., Willson, T., Lienhard, M., Prasse, P., Bachmann, I., Ganzlin, J., Barel, G., Herwig, R., Oprea, T., Schlessinger, A., Drewry, D., Stolovitzky, G., Wennerberg, K., Guinney, J., Aittokallio, T.

Publikováno v: Nature Communications

Despite decades of intensive search for compounds that modulate the activity of particular protein targets, a large proportion of the human kinome remains as yet undrugged. Effective approaches are therefore required to map the massive space of unexp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1874::e1007e5831d53fbec840688212987446
https://hdl.handle.net/21.11116/0000-0008-C1E2-E21.11116/0000-0008-C1E4-C

Drug repurposing from the perspective of pharmaceutical companies

Autor: Cha, Y, Erez, T, Reynolds, I J, Kumar, D, Ross, J, Koytiger, G, Kusko, R, Zeskind, B, Risso, S, Kagan, E, Papapetropoulos, S, Grossman, I, Laifenfeld, D

Drug repurposing holds the potential to bring medications with known safety profiles to new patient populations. Numerous examples exist for the identification of new indications for existing molecules, most stemming from serendipitous findings or fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08da83280b54d931b09b2d8070d113d3
https://europepmc.org/articles/PMC5758385/

Crowdsourced mapping of unexplored target space of kinase inhibitors.

Autor: Cichońska A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Computer Science, Helsinki Institute for Information Technology (HIIT), Aalto University, Espoo, Finland.; Department of Computing, University of Turku, Turku, Finland., Ravikumar B; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Allaway RJ; Computational Oncology, Sage Bionetworks, Seattle, WA, USA., Wan F; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China., Park S; Department of Computer Science and Engineering, Korea University, Seoul, Republic of Korea., Isayev O; Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA., Li S; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China., Mason M; Computational Oncology, Sage Bionetworks, Seattle, WA, USA., Lamb A; Computational Oncology, Sage Bionetworks, Seattle, WA, USA., Tanoli Z; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Jeon M; Department of Computer Science and Engineering, Korea University, Seoul, Republic of Korea., Kim S; Department of Computer Science and Engineering, Korea University, Seoul, Republic of Korea., Popova M; Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA., Capuzzi S; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Zeng J; Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China., Dang K; Computational Oncology, Sage Bionetworks, Seattle, WA, USA., Koytiger G; Immuneering Corporation, Cambridge, MA, USA., Kang J; Department of Computer Science and Engineering, Korea University, Seoul, Republic of Korea., Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Willson TM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Oprea TI; Translational Informatics Division and Comprehensive Cancer Center, University of New Mexico School of Medicine, Albuquerque, NM, USA., Schlessinger A; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Drewry DH; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Stolovitzky G; IBM T J Watson Research Center, IBM, Yorktown Heights, NY, USA., Wennerberg K; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark. krister.wennerberg@bric.ku.dk., Guinney J; Computational Oncology, Sage Bionetworks, Seattle, WA, USA. jguinney@gmail.com., Aittokallio T; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland. tero.aittokallio@helsinki.fi.; Department of Computer Science, Helsinki Institute for Information Technology (HIIT), Aalto University, Espoo, Finland. tero.aittokallio@helsinki.fi.; Department of Mathematics and Statistics, University of Turku, Turku, Finland. tero.aittokallio@helsinki.fi.; Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. tero.aittokallio@helsinki.fi.; Oslo Centre for Biostatistics and Epidemiology (OCBE), University of Oslo, Oslo, Norway. tero.aittokallio@helsinki.fi.

Publikováno v: Nature communications [Nat Commun] 2021 Jun 03; Vol. 12 (1), pp. 3307. Date of Electronic Publication: 2021 Jun 03.

The Prospect and Challenges of Repurposing Established Drugs in Pulmonary Arterial Hypertension.

Autor: Sener, Sila Ozlem^1,2 silaozlem.sener@sbu.edu.tr, Nasim, Rateep³ rn283@kent.ac.uk, Nasim, Talat¹ t.nasim@bradford.ac.uk

Publikováno v: BioChem. Sep2024, Vol. 4 Issue 3, p236-251. 16p.

Trends in orphan medicinal products approvals in the European Union between 2010–2022.

Autor: Bouwman, Luísa^1,2 (AUTHOR) mlbouwman@edu.ulisboa.pt, Sepodes, Bruno^1,2 (AUTHOR), Leufkens, Hubert^1,3 (AUTHOR), Torre, Carla^1,2 (AUTHOR)

Publikováno v: Orphanet Journal of Rare Diseases. 2/26/2024, p1-16. 16p.