Lipopolysaccharide-induced sepsis impairs M2R-GIRK signaling in the mouse sinoatrial node.

Autor: Shrestha N; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria., Zorn-Pauly K; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria., Mesirca P; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, Inserm, 34094 Montpellier, France.; Laboratory of Excellence in Ion Channels Science and Therapeutics, 34094 Montpellier, France., Koyani CN; Division of Cardiology, Medical University of Graz, 8036 Graz, Austria., Wölkart G; Department of Pharmacology and Toxicology, University of Graz, 8010 Graz, Austria., Di Biase V; Institute of Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Torre E; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, Inserm, 34094 Montpellier, France.; Laboratory of Excellence in Ion Channels Science and Therapeutics, 34094 Montpellier, France., Lang P; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria., Gorischek A; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria., Schreibmayer W; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria., Arnold R; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria., Maechler H; Division of Cardiac Surgery, Medical University of Graz, 8036 Graz, Austria., Mayer B; Department of Pharmacology and Toxicology, University of Graz, 8010 Graz, Austria., von Lewinski D; Division of Cardiology, Medical University of Graz, 8036 Graz, Austria., Torrente AG; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, Inserm, 34094 Montpellier, France.; Laboratory of Excellence in Ion Channels Science and Therapeutics, 34094 Montpellier, France., Mangoni ME; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, Inserm, 34094 Montpellier, France.; Laboratory of Excellence in Ion Channels Science and Therapeutics, 34094 Montpellier, France., Pelzmann B; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria., Scheruebel S; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jul 11; Vol. 120 (28), pp. e2210152120. Date of Electronic Publication: 2023 Jul 05.

β-catenin regulates FOXP2 transcriptional activity via multiple binding sites.

Autor: Richter G; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Austria., Gui T; Oncode Institute and Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, The Netherlands., Bourgeois B; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Austria., Koyani CN; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Austria.; Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Austria., Ulz P; Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Austria., Heitzer E; Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Austria., von Lewinski D; Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Austria., Burgering BMT; Oncode Institute and Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, The Netherlands., Malle E; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Austria., Madl T; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Austria.; BioTechMed, Graz, Austria.

Publikováno v: The FEBS journal [FEBS J] 2021 May; Vol. 288 (10), pp. 3261-3284. Date of Electronic Publication: 2020 Dec 26.

Nicotinamide for the treatment of heart failure with preserved ejection fraction.

Autor: Abdellatif M; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., Trummer-Herbst V; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., Koser F; Institute of Physiology II, University of Münster, Münster 48149, Germany., Durand S; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif 94805, France.; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris 75006, France., Adão R; Department of Cardiology, Medical University of Graz, Graz 8036, Austria.; Department of Surgery and Physiology, Cardiovascular Research and Development Centre (UnIC), Faculty of Medicine, University of Porto, Porto 4200-319, Portugal., Vasques-Nóvoa F; Department of Surgery and Physiology, Cardiovascular Research and Development Centre (UnIC), Faculty of Medicine, University of Porto, Porto 4200-319, Portugal., Freundt JK; Institute of Physiology II, University of Münster, Münster 48149, Germany., Voglhuber J; Department of Cardiology, Medical University of Graz, Graz 8036, Austria.; BioTechMed Graz, Graz 8010, Austria., Pricolo MR; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain., Kasa M; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., Türk C; Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Cologne 50931, Germany.; Center for Molecular Medicine (CMMC), University of Cologne, Cologne 50931, Germany., Aprahamian F; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif 94805, France.; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris 75006, France., Herrero-Galán E; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain., Hofer SJ; Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz 8010, Austria., Pendl T; Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz 8010, Austria., Rech L; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., Kargl J; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz 8010, Austria., Anto-Michel N; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., Ljubojevic-Holzer S; Department of Cardiology, Medical University of Graz, Graz 8036, Austria.; BioTechMed Graz, Graz 8010, Austria., Schipke J; Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover 30625, Germany., Brandenberger C; Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover 30625, Germany., Auer M; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz 8010, Austria.; Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz 8010, Austria., Schreiber R; Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz 8010, Austria., Koyani CN; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., Heinemann A; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz 8010, Austria., Zirlik A; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., Schmidt A; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., von Lewinski D; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., Scherr D; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., Rainer PP; Department of Cardiology, Medical University of Graz, Graz 8036, Austria.; BioTechMed Graz, Graz 8010, Austria., von Maltzahn J; Leibniz Institute on Aging, Jena 07745, Germany., Mühlfeld C; Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover 30625, Germany., Krüger M; Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Cologne 50931, Germany.; Center for Molecular Medicine (CMMC), University of Cologne, Cologne 50931, Germany., Frank S; BioTechMed Graz, Graz 8010, Austria.; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz 8010, Austria., Madeo F; BioTechMed Graz, Graz 8010, Austria.; Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz 8010, Austria., Eisenberg T; BioTechMed Graz, Graz 8010, Austria.; Institute of Molecular Biosciences, University of Graz, NAWI Graz, Graz 8010, Austria., Prokesch A; BioTechMed Graz, Graz 8010, Austria.; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz 8010, Austria.; Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz 8010, Austria., Leite-Moreira AF; Department of Surgery and Physiology, Cardiovascular Research and Development Centre (UnIC), Faculty of Medicine, University of Porto, Porto 4200-319, Portugal., Lourenço AP; Department of Surgery and Physiology, Cardiovascular Research and Development Centre (UnIC), Faculty of Medicine, University of Porto, Porto 4200-319, Portugal., Alegre-Cebollada J; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain., Kiechl S; Department of Neurology, Medical University of Innsbruck, Innsbruck 6020, Austria.; VASCage, Research Centre for Promoting Vascular Health in the Ageing Community, Innsbruck 6020, Austria., Linke WA; Institute of Physiology II, University of Münster, Münster 48149, Germany., Kroemer G; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif 94805, France. simon.sedej@medunigraz.at kroemer@orange.fr.; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris 75006, France.; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris 75015, France.; Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou 215000, China.; Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Solna 17164, Sweden., Sedej S; Department of Cardiology, Medical University of Graz, Graz 8036, Austria. simon.sedej@medunigraz.at kroemer@orange.fr.; BioTechMed Graz, Graz 8010, Austria.; Faculty of Medicine, University of Maribor, Maribor 2000, Slovenia.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Feb 10; Vol. 13 (580).

Empagliflozin protects heart from inflammation and energy depletion via AMPK activation.

Autor: Koyani CN; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. Electronic address: cnkoyani@yahoo.com., Plastira I; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, 8010 Graz, Austria., Sourij H; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria; Center for Biomarker Research in Medicine, 8036 Graz, Austria., Hallström S; Division of Physiological Chemistry, Otto Loewi Research Center, Medical University Graz, 8010 Graz, Austria., Schmidt A; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria., Rainer PP; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria., Bugger H; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria., Frank S; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, 8010 Graz, Austria., Malle E; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, 8010 Graz, Austria., von Lewinski D; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. Electronic address: dirk.von-lewinski@medunigraz.at.

Publikováno v: Pharmacological research [Pharmacol Res] 2020 Aug; Vol. 158, pp. 104870. Date of Electronic Publication: 2020 May 17.

Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes.

Autor: Koyani CN; Division of Cardiology, Medical University of Graz, Graz, Austria., Trummer C; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria., Shrestha N; Biophysics, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria., Scheruebel S; Biophysics, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria., Bourgeois B; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria., Plastira I; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria., Kickmaier S; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria., Sourij H; Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.; Center for Biomarker Research in Medicine, Graz, Austria., Rainer PP; Division of Cardiology, Medical University of Graz, Graz, Austria., Madl T; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria., Sattler W; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria., Pelzmann B; Biophysics, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria., Malle E; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria., von Lewinski D; Division of Cardiology, Medical University of Graz, Graz, Austria.

Publikováno v: Frontiers in physiology [Front Physiol] 2018 Nov 14; Vol. 9, pp. 1622. Date of Electronic Publication: 2018 Nov 14 (Print Publication: 2018).