Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Koya Fukunaga"'
Autor:
Ahmed El‐Boraie, Julie‐Anne Tanner, Andy Z.X. Zhu, Katrina G. Claw, Bhagwat Prasad, Erin G. Schuetz, Kenneth E. Thummel, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Neal L. Benowitz, Caryn Lerman, Rachel F. Tyndale
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 204-220 (2022)
Abstract CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking‐related disease risk. The heritability of the NMR is 60–80%, yet weighted genetic risk score
Externí odkaz:
https://doaj.org/article/227fec3dc8d24dc2934491cf383a5b28
Autor:
Chakkaphan Runcharoen, Koya Fukunaga, Insee Sensorn, Nareenart Iemwimangsa, Sommon Klumsathian, Hang Tong, Nam Sy Vo, Ly Le, Tin Maung Hlaing, Myo Thant, Shamsul Mohd Zain, Zahurin Mohamed, Yuh-Fen Pung, Francis Capule, Jose Nevado, Catherine Lynn Silao, Zeina N. Al-Mahayri, Bassam R. Ali, Rika Yuliwulandari, Kinasih Prayuni, Hilyatuz Zahroh, Dzul Azri Mohamed Noor, Phonepadith Xangsayarath, Dalouny Xayavong, Sengchanh Kounnavong, Somphou Sayasone, Zoe Kordou, Ioannis Liopetas, Athina Tsikrika, Evangelia-Eirini Tsermpini, Maria Koromina, Christina Mitropoulou, George P. Patrinos, Aumpika Kesornsit, Angkana Charoenyingwattana, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol, Taisei Mushiroda, Wasun Chantratita
Publikováno v:
Human Genome Variation, Vol 8, Iss 1, Pp 1-6 (2021)
Abstract Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping
Externí odkaz:
https://doaj.org/article/d9ba2428e119486e956cf700ff929c5d
Autor:
Meta H. M. Diekstra, Jesse J. Swen, Loes F. M. van der Zanden, Sita H. Vermeulen, Epie Boven, Ron H. J. Mathijssen, Koya Fukunaga, Taisei Mushiroda, Fumiya Hongo, Egbert Oosterwijk, Anne Cambon-Thomsen, Daniel Castellano, Achim Fritsch, Jesus Garcia Donas, Cristina Rodriguez-Antona, Rob Ruijtenbeek, Marius T. Radu, Tim Eisen, Kerstin Junker, Max Roessler, Ulrich Jaehde, Tsuneharu Miki, Stefan Böhringer, Michiaki Kubo, Lambertus A. L. M. Kiemeney, Henk-Jan Guchelaar
Publikováno v:
Cancers, Vol 14, Iss 12, p 2838 (2022)
Individual response to sunitinib in metastatic renal cell carcinoma (mRCC) patients is highly variable. Earlier, sunitinib outcome was related to single nucleotide polymorphisms (SNPs) in CYP3A5 and ABCB1. Our aim is to provide novel insights into bi
Externí odkaz:
https://doaj.org/article/4b5c931b6b45440b8f701ddb18654c57
Autor:
Koya Fukunaga, Ken Kato, Takuji Okusaka, Takeo Saito, Masashi Ikeda, Teruhiko Yoshida, Hitoshi Zembutsu, Nakao Iwata, Taisei Mushiroda
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Variability in the enzymatic activity of N-acetyltransferase 2 (NAT2) is an important contributor to interindividual differences in drug responses. However, there is little information on functional differences in N-acetylation activities according t
Externí odkaz:
https://doaj.org/article/b1cd9917e30e40b192f8a82352d4445a
Autor:
Chieh-Wen Lo, Liushiqi Borjigin, Susumu Saito, Koya Fukunaga, Etsuko Saitou, Katsunori Okazaki, Tetsuya Mizutani, Satoshi Wada, Shin-nosuke Takeshima, Yoko Aida
Publikováno v:
Viruses, Vol 12, Iss 3, p 352 (2020)
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. However, less than 5% of BLV-infected cattle will develop lymphoma, suggesting that, in addition to viral infection, host genetic polymorphisms might play a role in disea
Externí odkaz:
https://doaj.org/article/5c1e3a9e96aa46f1836c4863f39f3a7c
Autor:
Siew-Kee Low, Koya Fukunaga, Atsushi Takahashi, Koichi Matsuda, Fumiya Hongo, Hiroyuki Nakanishi, Hiroshi Kitamura, Takamitsu Inoue, Yoichiro Kato, Yoshihiko Tomita, Satoshi Fukasawa, Tomoaki Tanaka, Kazuo Nishimura, Hirotsugu Uemura, Isao Hara, Masato Fujisawa, Hideyasu Matsuyama, Katsuyoshi Hashine, Katsunori Tatsugami, Hideki Enokida, Michiaki Kubo, Tsuneharu Miki, Taisei Mushiroda
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148177 (2016)
Sunitinib is a tyrosine kinase inhibitor and used as the first-line treatment for advanced renal cell carcinoma (RCC). Nevertheless, inter-individual variability of drug's toxicity was often observed among patients who received sunitinib treatment. T
Externí odkaz:
https://doaj.org/article/a276813a941f4f4aa59c01e5e9edcb45
Autor:
Tomonori Iyoda, Kanako Shimizu, Masami Kawamura, Jun Shinga, Takashi Watanabe, Koya Fukunaga, Taisei Mushiroda, Hideo Saka, Chiyoe Kitagawa, Shin-ichiro Shimamatsu, Mitsuhiro Takenoyama, Youko Suehiro, Takumi Imai, Ayumi Shintani, Suminobu Ito, Shin-ichiro Fujii
Publikováno v:
ImmunoHorizons. 7:1-16
NK cells are major effector cells involved in the elimination of early tumors and prevent metastasis. They often have an impaired function in patients with cancer. Preclinical studies have demonstrated NK cell activation as the adjunctive effect of i
Autor:
Alec W. R. Langlois, Ahmed El-Boraie, Jennie G. Pouget, Lisa Sanderson Cox, Jasjit S. Ahluwalia, Koya Fukunaga, Taisei Mushiroda, Jo Knight, Meghan J. Chenoweth, Rachel F. Tyndale
CYP2A6 metabolically inactivates nicotine. Faster CYP2A6 activity is associated with heavier smoking and higher lung cancer risk. The CYP2A6 gene is polymorphic, including functional structural variants (SV) such as gene deletions (CYP2A6*4), duplica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fefaa08f367ed6bac9bf50e0b275975
https://doi.org/10.1038/s10038-023-01148-y
https://doi.org/10.1038/s10038-023-01148-y
Autor:
Bhagwat Prasad, Ahmed El-Boraie, Rachel F. Tyndale, Kenneth E. Thummel, Caryn Lerman, Katrina G. Claw, Julie-Anne Tanner, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Neal L. Benowitz, Andy Z. X. Zhu, Erin G. Schuetz
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 15, Iss 1, Pp 204-220 (2022)
Clinical and translational science, vol 15, iss 1
Clinical and Translational Science, Vol 15, Iss 1, Pp 204-220 (2022)
Clinical and translational science, vol 15, iss 1
CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking‐related disease risk. The heritability of the NMR is 60–80%, yet weighted genetic risk scores (wGRSs)
Autor:
Panagiotis Bosganas, Aggeliki Charalampidi, Maria Koromina, Evangelia-Eirini Tsermpini, Wasun Chantratita, Zoe Kordou, Taisei Mushiroda, George P. Patrinos, Koya Fukunaga
Publikováno v:
Pharmacogenomics. 22:749-760
Aim: Regardless of the plethora of next-generation sequencing studies in the field of pharmacogenomics (PGx), the potential effect of covariate variables on PGx response within deeply phenotyped cohorts remains unexplored. Materials & methods: We exp