Does Transcription of Remote alpha-Globin Regulatory Elements Affect Their Function?

Autor: Kowalczyk, MS, Hughes, JR, Sharpe, JA, Brown, JM, Buckle, VJ, Wood, WG, Higgs, DR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d77606436a9dd7042b1b6bfcfbcd96a2
https://ora.ox.ac.uk/objects/uuid:d670c021-dc3c-4bf7-b2d7-98c34a42d7e1

Blood and immune development in human fetal bone marrow and Down syndrome.

Autor: Jardine L; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Haematology Department, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Webb S; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Goh I; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Quiroga Londoño M; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Reynolds G; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Mather M; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Olabi B; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Stephenson E; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Botting RA; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Horsfall D; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Engelbert J; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Maunder D; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Mende N; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Murnane C; Department of Paediatrics, University of Oxford, Oxford, UK., Dann E; Wellcome Sanger Institute, Hinxton, UK., McGrath J; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., King H; Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK., Kucinski I; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Queen R; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Carey CD; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Shrubsole C; Haematology Department, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Poyner E; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Acres M; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Jones C; NovoPath, Department of Pathology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Ness T; NovoPath, Department of Pathology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Coulthard R; NovoPath, Department of Pathology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Elliott N; Department of Paediatrics, University of Oxford, Oxford, UK., O'Byrne S; Department of Paediatrics, University of Oxford, Oxford, UK., Haltalli MLR; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Lawrence JE; Wellcome Sanger Institute, Hinxton, UK., Lisgo S; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Balogh P; Wellcome Sanger Institute, Hinxton, UK., Meyer KB; Wellcome Sanger Institute, Hinxton, UK., Prigmore E; Wellcome Sanger Institute, Hinxton, UK., Ambridge K; Wellcome Sanger Institute, Hinxton, UK., Jain MS; Wellcome Sanger Institute, Hinxton, UK., Efremova M; Barts Cancer Institute, Queen Mary University of London, London, UK., Pickard K; Haematology Department, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Creasey T; Haematology Department, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Wolfson Childhood Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK., Bacardit J; School of Computing, Newcastle University, Newcastle upon Tyne, UK., Henderson D; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Coxhead J; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Filby A; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Hussain R; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Dixon D; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., McDonald D; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Popescu DM; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Kowalczyk MS; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Li B; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Tabaka M; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Dionne D; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tickle TL; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Data Sciences Platform, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Slyper M; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Behjati S; Wellcome Sanger Institute, Hinxton, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Laurenti E; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Wilson NK; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Roy A; Department of Paediatrics, University of Oxford, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Department of Paediatrics, Children's Hospital, John Radcliffe Hospital, and MRC WIMM, University of Oxford, Oxford, UK.; BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK., Göttgens B; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Roberts I; Department of Paediatrics, University of Oxford, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Department of Paediatrics, Children's Hospital, John Radcliffe Hospital, and MRC WIMM, University of Oxford, Oxford, UK.; BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK., Teichmann SA; Wellcome Sanger Institute, Hinxton, UK.; Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, Cambridge, UK., Haniffa M; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK. m.a.haniffa@ncl.ac.uk.; Wellcome Sanger Institute, Hinxton, UK. m.a.haniffa@ncl.ac.uk.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. m.a.haniffa@ncl.ac.uk.

Publikováno v: Nature [Nature] 2021 Oct; Vol. 598 (7880), pp. 327-331. Date of Electronic Publication: 2021 Sep 29.

T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity.

Autor: Sungnak W; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Wagner A; Department of Electrical Engineering and Computer Science, Center for Computational Biology, University of California, Berkeley, CA 94720., Kowalczyk MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Bod L; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Kye YC; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Sage PT; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115., Sharpe AH; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115., Sobel RA; Department of Pathology, Stanford University, Stanford, CA 94305; and., Quintana FJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Wang C; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Yosef N; Department of Electrical Engineering and Computer Science, Center for Computational Biology, University of California, Berkeley, CA 94720., Kuchroo VK; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; vkuchroo@evergrande.hms.harvard.edu.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Dec 15; Vol. 205 (12), pp. 3247-3262. Date of Electronic Publication: 2020 Nov 09.

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes.

Autor: Lavaert M; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium., Liang KL; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium., Vandamme N; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium., Park JE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Roels J; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Kowalczyk MS; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Li B; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Data Sciences Platform, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tabaka M; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Dionne D; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tickle TL; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Haematology Department, Royal Victoria Infirmary, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Slyper M; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Vandekerckhove B; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium., Leclercq G; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium., Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Van Vlierberghe P; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Guilliams M; Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB Center for Inflammation Research, Ghent, Belgium; Faculty of Sciences, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK; Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK., Saeys Y; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium., Taghon T; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium. Electronic address: tom.taghon@ugent.be.

Publikováno v: Immunity [Immunity] 2020 Jun 16; Vol. 52 (6), pp. 1088-1104.e6. Date of Electronic Publication: 2020 Apr 17.

Systematic comparison of single-cell and single-nucleus RNA-sequencing methods.

Autor: Ding J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Adiconis X; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Simmons SK; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kowalczyk MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hession CC; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Marjanovic ND; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hughes TK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Koch Institute of Integrative Cancer Research, Cambridge, MA, USA., Wadsworth MH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Koch Institute of Integrative Cancer Research, Cambridge, MA, USA., Burks T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen LT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kwon JYH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Barak B; McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, USA., Ge W; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kedaigle AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Carroll S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Koch Institute of Integrative Cancer Research, Cambridge, MA, USA., Li S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Rozenblatt-Rosen O; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shalek AK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Koch Institute of Integrative Cancer Research, Cambridge, MA, USA., Villani AC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute of Integrative Cancer Research, Cambridge, MA, USA.; Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA, USA., Levin JZ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. jlevin@broadinstitute.org.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2020 Jun; Vol. 38 (6), pp. 737-746. Date of Electronic Publication: 2020 Apr 06.