Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kovilen, Sawmynaden"'
Autor:
Chen Jiang, Ahsan Javed, Laura Kaiser, Michele M. Nava, Rui Xu, Dominique T. Brandt, Dandan Zhao, Benjamin Mayer, Javier Fernández-Baldovinos, Luping Zhou, Carsten Höß, Kovilen Sawmynaden, Arkadiusz Oleksy, David Matthews, Lee S. Weinstein, Heidi Hahn, Hermann-Josef Gröne, Peter L. Graumann, Carien M. Niessen, Stefan Offermanns, Sara A. Wickström, Thomas Worzfeld
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of
Externí odkaz:
https://doaj.org/article/c31e77abae1d4cc9839c925693d0c2fb
Autor:
Georgia Bullen, Jacob D. Galson, Gareth Hall, Pedro Villar, Lien Moreels, Line Ledsgaard, Giada Mattiuzzo, Emma M. Bentley, Edward W. Masters, David Tang, Sophie Millett, Danielle Tongue, Richard Brown, Ioannis Diamantopoulos, Kothai Parthiban, Claire Tebbutt, Rachael Leah, Krishna Chaitanya, Sandra Ergueta-Carballo, Deividas Pazeraitis, Sachin B. Surade, Omodele Ashiru, Lucia Crippa, Richard Cowan, Matthew W. Bowler, Jamie I. Campbell, Wing-Yiu Jason Lee, Mark D. Carr, David Matthews, Paul Pfeffer, Simon E. Hufton, Kovilen Sawmynaden, Jane Osbourn, John McCafferty, Aneesh Karatt-Vellatt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Passive immunization using monoclonal antibodies will play a vital role in the fight against COVID-19. The recent emergence of viral variants with reduced sensitivity to some current antibodies and vaccines highlights the importance of broad cross-re
Externí odkaz:
https://doaj.org/article/ecdc7cf013814d728091e23cf673cdda
Autor:
Richard Cowan, Martina Trokter, Arkadiusz Oleksy, Marina Fedorova, Kovilen Sawmynaden, Thomas Worzfeld, Stefan Offermanns, David Matthews, Mark D. Carr, Gareth Hall
Publikováno v:
Journal of Biological Chemistry. 299:104740
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b88f2b49df4104c8ae5374cbd3cf1b71
https://doi.org/10.1016/j.jbc.2023.104740
https://doi.org/10.1016/j.jbc.2023.104740
Autor:
Eric Jou, Noe Rodriguez-Rodriguez, Ana-Carolina F. Ferreira, Helen E. Jolin, Paula A. Clark, Kovilen Sawmynaden, Michelle Ko, Jane E. Murphy, Jonathan Mannion, Christopher Ward, David J. Matthews, Simon J. A. Buczacki, Andrew N. J. McKenzie
Publikováno v:
Science Immunology
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) defend the host against intestinal helminth infection and are associated with inappropriate allergic reactions. IL-33–activated ILC2s were previously found to augment protective tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd5ab02a6b517faea2d58da77c6a5e7
Autor:
Tara Kang-Pettinger, Kayleigh Walker, Richard Brown, Richard Cowan, Helena Wright, Roberta Baravalle, Lorna C. Waters, Frederick W. Muskett, Matthew W. Bowler, Kovilen Sawmynaden, Peter J. Coombs, Mark D. Carr, Gareth Hall
Publikováno v:
Journal of Biological Chemistry. 299:102769
Programmed death-ligand 1 (PD-L1) is a key immune regulatory protein that interacts with programmed cell death protein 1 (PD-1), leading to T-cell suppression. Whilst this interaction is key in self-tolerance, cancer cells evade the immune system by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d2423a9d75186022993ce5b2c1159c
https://doi.org/10.1016/j.jbc.2022.102769
https://doi.org/10.1016/j.jbc.2022.102769
Autor:
Melanie Vogler, Arkadiusz Oleksy, Sabrina Schulze, Marina Fedorova, Baktybek Kojonazarov, Sharandip Nijjar, Seema Patel, Sian Jossi, Kovilen Sawmynaden, Maud Henry, Richard Brown, David Matthews, Stefan Offermanns, Thomas Worzfeld
Publikováno v:
Journal of Biological Chemistry. 298:102265
Osteoporosis and multiple sclerosis are highly prevalent diseases with limited treatment options. In light of these unmet medical needs, novel therapeutic approaches are urgently sought. Previously, the activation of the transmembrane receptor Plexin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5b37d35053c3256ac3ef3622f7cf44
https://doi.org/10.1016/j.jbc.2022.102265
https://doi.org/10.1016/j.jbc.2022.102265
Autor:
Hermann-Josef Groene, Dominique T. Brandt, Stefan Offermanns, Chen Jiang, Lee S. Weinstein, Arkadiusz Oleksy, David A. Matthews, Javier Fernandez-Baldovinos, Carsten Hoess, Carien M. Niessen, Laura Kaiser, Sara A. Wickström, Ahsan Javed, Thomas Worzfeld, Kovilen Sawmynaden, Luping Zhou, Dandan Zhao, Michele M. Nava
The precise spatiotemporal control of cell proliferation is key to the morphogenesis of epithelial tissues. Epithelial cell divisions lead to tissue crowding and local changes in force distribution, which in turn suppress the rate of cell divisions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980562200bf0b0fd3f38d22aad2a3634
https://doi.org/10.1101/2020.04.30.070359
https://doi.org/10.1101/2020.04.30.070359
Autor:
Kovilen Sawmynaden, Mark D. Carr, Gareth Hall, Debra L. Taylor, Eilish Cullen, Richard Cowan, Richard Bayliss, Simon Fox, Catherine A. Kettleborough, Frederick W. Muskett, William W. Cruikshank, David Matthews, Andrew Merritt, Joanne Arnold
Publikováno v:
Journal of Biological Chemistry. 291:16840-16848
Interleukin-16 (IL-16) is reported to be a chemoattractant cytokine and modulator of T-cell activation, and has been proposed as a ligand for the co-receptor CD4. The secreted active form of IL-16 has been detected at sites of TH1-mediated inflammati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e2847775886bdf5b4f02b6fce66f4b3
https://doi.org/10.1074/jbc.m115.709303
https://doi.org/10.1074/jbc.m115.709303
Autor:
Kothai Parthiban, Sandra Ergueta-Carballo, Aneesh Karatt-Vellatt, Omodele Ashiru, Jacob D. Galson, David A. Matthews, Simon E. Hufton, Deividas Pazeraitis, Edward W. Masters, Claire Tebbutt, Richard Cowan, Mark D. Carr, Wing-Yiu Jason Lee, Sachin Surade, Paul E Pfeffer, Lucia Crippa, Line Ledsgaard, Sophie Millett, Richard J. C. Brown, Danielle Tongue, Emma M. Bentley, Lien Moreels, John McCafferty, Georgia Bullen, Ioannis Diamantopoulos, Krishna Chaitanya, David Tang, Matthew W. Bowler, Pedro Villar, Giada Mattiuzzo, Jane K. Osbourn, Kovilen Sawmynaden, Jamie Campbell, Rachael A. Leah, Gareth Hall
Publikováno v:
'Frontiers in Immunology ', vol: 12, pages: 678570-1-678570-16 (2021)
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Passive immunization using monoclonal antibodies will play a vital role in the fight against COVID-19. The recent emergence of viral variants with reduced sensitivity to some current antibodies and vaccines highlights the importance of broad cross-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a953a50b3fae994dc53f035d9fe407c
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57761
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57761
Autor:
Peter Simpson, Jan Marchant, Michael J. Blackman, Nikolas Friedrich, Stephen Matthews, Kovilen Sawmynaden, Boris Bleijlevens, Dominique Soldati-Favre, Savvas Saouros
Publikováno v:
EMBO reports, Vol. 9, No 11 (2008) pp. 1149-55
EMBO reports, 9(11), 1149-1155. Wiley-Blackwell
EMBO reports, 9(11), 1149-1155. Wiley-Blackwell
The obligate intracellular parasite Toxoplasma gondii, a member of the phylum Apicomplexa that includes Plasmodium spp., is one of the most widespread parasites and the causative agent of toxoplasmosis. Adhesive complexes composed of microneme protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d1e4ef063f102e99efb286b0e45145
https://doi.org/10.1038/embor.2008.179
https://doi.org/10.1038/embor.2008.179