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Akademický článek

Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors.

Autor: Tong Y; Drug Discovery Science & Technology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Florjancic AS; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Clark RF; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Lai C; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Mastracchio A; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Zhu GD; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Smith ML; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kovar PJ; High Throughput Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Shaw B; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Albert DH; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Qiu W; Structural Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Longenecker KL; Structural Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Liu X; Pharmacology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Olson AM; Pharmacology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Osterling DJ; Pharmacology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Tahir SK; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Phillips DC; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Leverson JD; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Souers AJ; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Penning TD; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jun 22; Vol. 12 (7), pp. 1108-1115. Date of Electronic Publication: 2021 Jun 22 (Print Publication: 2021).

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Akademický článek

Structure-Based Design of A-1293102, a Potent and Selective BCL-X L Inhibitor.

Autor: Tao ZF; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Wang X; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Chen J; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Ingram JP; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Jin S; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Judge RA; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Kovar PJ; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Park C; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Sun C; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Wakefield BD; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Zhou L; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Zhang H; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Elmore SW; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Phillips DC; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Judd AS; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Leverson JD; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Souers AJ; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 May 12; Vol. 12 (6), pp. 1011-1016. Date of Electronic Publication: 2021 May 12 (Print Publication: 2021).

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Akademický článek

Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.

Autor: Sheppard GS; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wang L; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Fidanze SD; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Hasvold LA; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Liu D; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Pratt JK; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Park CH; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Longenecker K; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Qiu W; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Torrent M; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kovar PJ; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Bui M; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Faivre E; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Huang X; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Lin X; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wilcox D; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Zhang L; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Shen Y; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Albert DH; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Magoc TJ; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Rajaraman G; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kati WM; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., McDaniel KF; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 May 28; Vol. 63 (10), pp. 5585-5623. Date of Electronic Publication: 2020 May 07.

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Akademický článek

Controlling cellular distribution of drugs with permeability modifying moieties.

Autor: Richardson PL; Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email: paul.l.richardson@abbvie.com., Marin VL; Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email: paul.l.richardson@abbvie.com., Koeniger SL; Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email: paul.l.richardson@abbvie.com., Baranczak A; Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email: paul.l.richardson@abbvie.com., Wilsbacher JL; Discovery Oncology , AbbVie Inc. , USA., Kovar PJ; Discovery Oncology , AbbVie Inc. , USA., Bacon-Trusk PE; Discovery Oncology , AbbVie Inc. , USA., Cheng M; Discovery Oncology , AbbVie Inc. , USA., Hopkins TA; Discovery Oncology , AbbVie Inc. , USA., Haman ST; Discovery Oncology , AbbVie Inc. , USA., Vasudevan A; Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email: paul.l.richardson@abbvie.com.

Publikováno v: MedChemComm [Medchemcomm] 2019 Apr 18; Vol. 10 (6), pp. 974-984. Date of Electronic Publication: 2019 Apr 18 (Print Publication: 2019).

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