Zobrazeno 1 - 10 of 110 pro vyhledávání: '"Kovar PJ"'
1
Akademický článek
Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors.
Autor: Tong Y; Drug Discovery Science & Technology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Florjancic AS; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Clark RF; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Lai C; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Mastracchio A; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Zhu GD; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Smith ML; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kovar PJ; High Throughput Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Shaw B; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Albert DH; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Qiu W; Structural Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Longenecker KL; Structural Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Liu X; Pharmacology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Olson AM; Pharmacology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Osterling DJ; Pharmacology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Tahir SK; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Phillips DC; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Leverson JD; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Souers AJ; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Penning TD; Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jun 22; Vol. 12 (7), pp. 1108-1115. Date of Electronic Publication: 2021 Jun 22 (Print Publication: 2021).
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2
Akademický článek
Structure-Based Design of A-1293102, a Potent and Selective BCL-X L Inhibitor.
Autor: Tao ZF; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Wang X; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Chen J; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Ingram JP; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Jin S; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Judge RA; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Kovar PJ; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Park C; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Sun C; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Wakefield BD; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Zhou L; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Zhang H; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Elmore SW; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Phillips DC; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Judd AS; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Leverson JD; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States., Souers AJ; AbbVie Inc., 1 North Waukegan Rd, North Chicago, Illinois 60064, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 May 12; Vol. 12 (6), pp. 1011-1016. Date of Electronic Publication: 2021 May 12 (Print Publication: 2021).
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3
Akademický článek
Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
Autor: Sheppard GS; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wang L; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Fidanze SD; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Hasvold LA; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Liu D; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Pratt JK; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Park CH; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Longenecker K; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Qiu W; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Torrent M; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kovar PJ; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Bui M; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Faivre E; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Huang X; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Lin X; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wilcox D; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Zhang L; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Shen Y; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Albert DH; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Magoc TJ; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Rajaraman G; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kati WM; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., McDaniel KF; Oncology Discovery, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 May 28; Vol. 63 (10), pp. 5585-5623. Date of Electronic Publication: 2020 May 07.
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4
Akademický článek
Controlling cellular distribution of drugs with permeability modifying moieties.
Autor: Richardson PL; Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email: paul.l.richardson@abbvie.com., Marin VL; Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email: paul.l.richardson@abbvie.com., Koeniger SL; Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email: paul.l.richardson@abbvie.com., Baranczak A; Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email: paul.l.richardson@abbvie.com., Wilsbacher JL; Discovery Oncology , AbbVie Inc. , USA., Kovar PJ; Discovery Oncology , AbbVie Inc. , USA., Bacon-Trusk PE; Discovery Oncology , AbbVie Inc. , USA., Cheng M; Discovery Oncology , AbbVie Inc. , USA., Hopkins TA; Discovery Oncology , AbbVie Inc. , USA., Haman ST; Discovery Oncology , AbbVie Inc. , USA., Vasudevan A; Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email: paul.l.richardson@abbvie.com.
Publikováno v: MedChemComm [Medchemcomm] 2019 Apr 18; Vol. 10 (6), pp. 974-984. Date of Electronic Publication: 2019 Apr 18 (Print Publication: 2019).
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5
Akademický článek
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Autor: Curtin ML; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com., Heyman HR; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Clark RF; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sorensen BK; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Doherty GA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Hansen TM; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Frey RR; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sarris KA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Aguirre AL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Shrestha A; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Tu N; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Woller K; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Pliushchev MA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sweis RF; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Cheng M; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Wilsbacher JL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Kovar PJ; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Guo J; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Cheng D; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Longenecker KL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Raich D; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Korepanova AV; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Soni NB; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Algire MA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Richardson PL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Marin VL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Badagnani I; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Vasudevan A; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Buchanan FG; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Maag D; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Chiang GG; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Tse C; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Michaelides MR; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Aug 01; Vol. 27 (15), pp. 3317-3325. Date of Electronic Publication: 2017 Jun 14.
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6
Akademický článek
Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Autor: Wilsbacher JL; AbbVie Inc., North Chicago, Illinois. julie.wilsbacher@abbvie.com., Cheng M; AbbVie Inc., North Chicago, Illinois., Cheng D; AbbVie Inc., North Chicago, Illinois., Trammell SAJ; Department of Biochemistry Carver College of Medicine, University of Iowa, Iowa City, Iowa., Shi Y; AbbVie Inc., North Chicago, Illinois., Guo J; AbbVie Inc., North Chicago, Illinois., Koeniger SL; AbbVie Inc., North Chicago, Illinois., Kovar PJ; AbbVie Inc., North Chicago, Illinois., He Y; AbbVie Inc., North Chicago, Illinois., Selvaraju S; AbbVie Inc., North Chicago, Illinois., Heyman HR; AbbVie Inc., North Chicago, Illinois., Sorensen BK; AbbVie Inc., North Chicago, Illinois., Clark RF; AbbVie Inc., North Chicago, Illinois., Hansen TM; AbbVie Inc., North Chicago, Illinois., Longenecker KL; AbbVie Inc., North Chicago, Illinois., Raich D; AbbVie Inc., North Chicago, Illinois., Korepanova AV; AbbVie Inc., North Chicago, Illinois., Cepa S; AbbVie Inc., North Chicago, Illinois., Towne DL; AbbVie Inc., North Chicago, Illinois., Abraham VC; AbbVie Inc., North Chicago, Illinois., Tang H; AbbVie Inc., North Chicago, Illinois., Richardson PL; AbbVie Inc., North Chicago, Illinois., McLoughlin SM; AbbVie Inc., North Chicago, Illinois., Badagnani I; AbbVie Inc., North Chicago, Illinois., Curtin ML; AbbVie Inc., North Chicago, Illinois., Michaelides MR; AbbVie Inc., North Chicago, Illinois., Maag D; AbbVie Inc., North Chicago, Illinois., Buchanan FG; AbbVie Inc., North Chicago, Illinois., Chiang GG; AbbVie Inc., North Chicago, Illinois., Gao W; AbbVie Inc., North Chicago, Illinois., Rosenberg SH; AbbVie Inc., North Chicago, Illinois., Brenner C; Department of Biochemistry Carver College of Medicine, University of Iowa, Iowa City, Iowa., Tse C; AbbVie Inc., North Chicago, Illinois.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2017 Jul; Vol. 16 (7), pp. 1236-1245. Date of Electronic Publication: 2017 May 03.
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8
Akademický článek
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
Autor: Bruncko M; AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wang L, Sheppard GS, Phillips DC, Tahir SK, Xue J, Erickson S, Fidanze S, Fry E, Hasvold L, Jenkins GJ, Jin S, Judge RA, Kovar PJ, Madar D, Nimmer P, Park C, Petros AM, Rosenberg SH, Smith ML, Song X, Sun C, Tao ZF, Wang X, Xiao Y, Zhang H, Tse C, Leverson JD, Elmore SW, Souers AJ
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Mar 12; Vol. 58 (5), pp. 2180-94. Date of Electronic Publication: 2015 Feb 26.
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10
Akademický článek
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
Autor: Tao ZF; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Hasvold L; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Wang L; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Wang X; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Petros AM; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Park CH; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Boghaert ER; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Catron ND; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Chen J; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Colman PM; The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, VIC 3010, Australia., Czabotar PE; The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, VIC 3010, Australia., Deshayes K; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080 United States., Fairbrother WJ; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080 United States., Flygare JA; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080 United States., Hymowitz SG; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080 United States., Jin S; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Judge RA; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Koehler MF; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080 United States., Kovar PJ; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Lessene G; The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, VIC 3010, Australia ; Department of Pharmacology and Therapeutics, The University of Melbourne , Parkville, VIC 3010, Australia., Mitten MJ; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Ndubaku CO; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080 United States., Nimmer P; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Purkey HE; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080 United States., Oleksijew A; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Phillips DC; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Sleebs BE; The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, VIC 3010, Australia., Smith BJ; The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, VIC 3010, Australia., Smith ML; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Tahir SK; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Watson KG; The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, VIC 3052, Australia ; Department of Medical Biology, The University of Melbourne , Parkville, VIC 3010, Australia., Xiao Y; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Xue J; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Zhang H; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Zobel K; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080 United States., Rosenberg SH; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Tse C; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Leverson JD; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Elmore SW; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States., Souers AJ; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064 United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2014 Aug 26; Vol. 5 (10), pp. 1088-93. Date of Electronic Publication: 2014 Aug 26 (Print Publication: 2014).
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