Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Kovaltsuk, A"'
Autor:
Kenlay, Henry, Dreyer, Frédéric A., Kovaltsuk, Aleksandr, Miketa, Dom, Pires, Douglas, Deane, Charlotte M.
Antibodies are proteins produced by the immune system that can identify and neutralise a wide variety of antigens with high specificity and affinity, and constitute the most successful class of biotherapeutics. With the advent of next-generation sequ
Externí odkaz:
http://arxiv.org/abs/2403.17889
Autor:
Eve Richardson, Špela Binter, Miha Kosmac, Marie Ghraichy, Valentin von Niederhäusern, Aleksandr Kovaltsuk, Jacob D Galson, Johannes Trück, Dominic F Kelly, Charlotte M Deane, Paul Kellam, Simon J Watson
Publikováno v:
eLife, Vol 12 (2023)
Immunoglobulin loci-transgenic animals are widely used in antibody discovery and increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell populations from the Intelliselect Transgenic mouse (Kymouse) demonstra
Externí odkaz:
https://doaj.org/article/8edf1acdf29a48b99e78fa6ee6f633dc
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1197-1205 (2019)
Recently it has become possible to query the great diversity of natural antibody repertoires using next-generation sequencing (NGS). These methods are capable of producing millions of sequences in a single experiment. Here we compare clinical-stage t
Externí odkaz:
https://doaj.org/article/9fac36b893fe4d57bb5d7f7313e7b4ce
Autor:
Marie Ghraichy, Valentin von Niederhäusern, Aleksandr Kovaltsuk, Jacob D Galson, Charlotte M Deane, Johannes Trück
Publikováno v:
eLife, Vol 10 (2021)
Several human B cell subpopulations are recognised in the peripheral blood, which play distinct roles in the humoral immune response. These cells undergo developmental and maturational changes involving VDJ recombination, somatic hypermutation and cl
Externí odkaz:
https://doaj.org/article/19f3a9204ee7438d934efd000e121258
Autor:
Matthew I J Raybould, Claire Marks, Aleksandr Kovaltsuk, Alan P Lewis, Jiye Shi, Charlotte M Deane
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008781 (2021)
The naïve antibody/B-cell receptor (BCR) repertoires of different individuals ought to exhibit significant functional commonality, given that most pathogens trigger an effective antibody response to immunodominant epitopes. Sequence-based repertoire
Externí odkaz:
https://doaj.org/article/25733d2a183f483f900eb2877fe4c75c
Autor:
Jacob D. Galson, Sebastian Schaetzle, Rachael J. M. Bashford-Rogers, Matthew I. J. Raybould, Aleksandr Kovaltsuk, Gavin J. Kilpatrick, Ralph Minter, Donna K. Finch, Jorge Dias, Louisa K. James, Gavin Thomas, Wing-Yiu Jason Lee, Jason Betley, Olivia Cavlan, Alex Leech, Charlotte M. Deane, Joan Seoane, Carlos Caldas, Daniel J. Pennington, Paul Pfeffer, Jane Osbourn
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19 patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which is consistent across patients. Clonal expansion of the B cell population is also
Externí odkaz:
https://doaj.org/article/77318244b0ea49a7afe210f8b341f044
Autor:
Marie Ghraichy, Jacob D. Galson, Aleksandr Kovaltsuk, Valentin von Niederhäusern, Jana Pachlopnik Schmid, Mike Recher, Annaïse J. Jauch, Enkelejda Miho, Dominic F. Kelly, Charlotte M. Deane, Johannes Trück
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienc
Externí odkaz:
https://doaj.org/article/3d8e2d4d774f4162930c2bb20c9aa73e
Autor:
Aleksandr Kovaltsuk, Matthew I J Raybould, Wing Ki Wong, Claire Marks, Sebastian Kelm, James Snowden, Johannes Trück, Charlotte M Deane
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007636 (2020)
Most current analysis tools for antibody next-generation sequencing data work with primary sequence descriptors, leaving accompanying structural information unharnessed. We have used novel rapid methods to structurally characterize the complementary-
Externí odkaz:
https://doaj.org/article/a1a3d6bfc23646c3895acfba9e2ad92f
Akademický článek
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Autor:
E Richardson, Š Binter, M Kosmac, M Ghraichy, V von Niederhausern, A Kovaltsuk, J Galson, J Trück, DF Kelly, CM Deane, P Kellam, SJ Watson
Publikováno v:
eLife. 12
Immunoglobulin loci-transgenic animals are widely used in antibody discovery and increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell populations from the Intelliselect® Transgenic mouse (Kymouse) demonst