Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Kousuke Tani"'
Autor:
Yasuyuki Kurihara, MD, Takayuki Honda, MD, PhD, Akira Takemoto, MD, PhD, Katsutoshi Seto, MD, PhD, Satoshi Endo, MD, Kousuke Tanimoto, MD, PhD, Susumu Kirimura, MD, PhD, Masashi Kobayashi, MD, PhD, Shunichi Baba, MD, PhD, Yasuhiro Nakashima, MD, PhD, Ryo Wakejima, MD, PhD, Rie Sakakibara, MD, PhD, Hironori Ishibashi, MD, PhD, Johji Inazawa, MD, PhD, Toshihiro Tanaka, MD, PhD, Yasunari Miyazaki, MD, PhD, Kenichi Okubo, MD, PhD
Publikováno v:
JTCVS Open, Vol 20, Iss , Pp 183-193 (2024)
Introduction: TP53 is a strong tumor suppressor gene; its deactivation contributes to carcinogenesis and influences clinical outcomes. However, the prognostic influence of p53 deactivation on early relapse in patients with surgically resected non–s
Externí odkaz:
https://doaj.org/article/4102ee1106d24518a153130f60139603
Autor:
Takayuki Honda, Katsutoshi Seto, Satoshi Endo, Akira Takemoto, Kousuke Tanimoto, Masashi Kobayashi, Masatake Kitano, Rie Sakakibara, Takahiro Mitsumura, Hironori Ishibashi, Johji Inazawa, Toshihiro Tanaka, Yasunari Miyazaki, Kenichi Okubo
Publikováno v:
Cancer Medicine, Vol 12, Iss 19, Pp 19406-19413 (2023)
Abstract Background The recurrence rate of non‐small cell lung cancer (NSCLC) is as high as 30%, even in the cancer with pathological stage I disease. Therefore, identifying factors predictive of high‐risk pathological recurrence is important. Ho
Externí odkaz:
https://doaj.org/article/6ba7b431ba7f44a4957e152056f0c6c6
Autor:
Tohru Kambe, Satoshi Shuto, Tomotaka Okino, Taihei Nishiyama, Kousuke Tani, Nobukazu Ohta, Tetsuo Obitsu, Akihiro Kinoshita, Shinsaku Yamane, Taku Fujimoto, Isamu Sugimoto, Hiromu Egashira, Toru Maruyama
Publikováno v:
ACS Medicinal Chemistry Letters. 8:107-112
A novel series of prostaglandin analogues with a seven-membered ring scaffold was designed, synthesized, and evaluated for the functional activation of prostaglandin receptors to identify potent and subtype-selective FP and EP3 dual agonists. Startin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bddff87eed505a24e60327db9d3e0e4
https://doi.org/10.1021/acsmedchemlett.6b00415
https://doi.org/10.1021/acsmedchemlett.6b00415
Autor:
Taro Fujikawa, Kousuke Tanimoto, Yoshiyuki Kawashima, Taku Ito, Keiji Honda, Takamori Takeda, Akane Sonobe, Natsuki Aoki, Jing Bai, Takeshi Tsutsumi
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 7, Iss 6, Pp 2011-2019 (2022)
Abstract Objective To compare the microbiota between cholesteatoma and chronic suppurative otitis media (COM) and to identify potential pathogens that explain the relevant phenotypes of cholesteatoma. Study Design Prospective cohort study. Methods Su
Externí odkaz:
https://doaj.org/article/b400ef655eef4e71bf06e74d614be85a
Autor:
Seiji Ogawa, Toru Maruyama, Takuya Okada, Kousuke Tani, Yoshikazu Goto, Shinsaku Yamane, Toshihide Watanabe, Akio Watanabe, Kazuma Tsuboi, Kazumi Moriyuki, Hiroyuki Takeda, Atsushi Kinoshita
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(10)
The modification of the novel G protein-biased EP2 agonist 1 has been investigated to improve its G protein activity and develop a better understanding of its structure-functional selectivity relationship (SFSR). The optimization of the substituents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53061ae3c619ac4edab423f7f88a0a8
https://pubmed.ncbi.nlm.nih.gov/27055938
https://pubmed.ncbi.nlm.nih.gov/27055938
Autor:
Yoko Matsunaga, Seiji Ogawa, Hisao Nakai, Yutaka Okada, Atsushi Shimabukuro, Kohki Tsukamoto, Fumio Nambu, Atsushi Kinoshita, Rie Oumi, Yoshihiko Odagaki, Ryoji Matsumoto, Atsushi Naganawa, Jun Katagi, Maki Iwahashi, Koji Yano, Masaaki Toda, Toshihiko Nishiyama, Kousuke Tani
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:6935-6948
To identify an orally available drug candidate, a series of 3-benzoylaminophenylacetic acids were synthesized and evaluated as prostaglandin D2 (PGD2) receptor antagonists. Some of the compounds tested were found to exhibit excellent inhibitory activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee81d7e76196c761d039147212cacff
https://doi.org/10.1016/j.bmc.2011.08.065
https://doi.org/10.1016/j.bmc.2011.08.065
Autor:
Hua Zhu, Takaya Higuchi, Tsuyoshi Imai, Zhenjia Zhang, Kousuke Tani, Masao Ukita, Masahiko Sekine
Publikováno v:
Water Science and Technology. 55:183-191
In aerated ponds, oxygen is generally supplied through either diffused or mechanical aeration means. Surface transfer and bubble transfer both contribute significantly to oxygen transfer in a diffused aeration system. In the present study, a liquid-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ebbf9edf69e61d73c7ca24e66be24a
https://doi.org/10.2166/wst.2007.353
https://doi.org/10.2166/wst.2007.353
Autor:
Tsuyoshi Imai, Masao Ukita, Zhenjia Zhang, Takaya Higuchi, Hua Zhu, Masahiko Sekine, Kousuke Tani
Publikováno v:
Environmental Technology. 28:511-519
Surface transfer and bubble transfer both contribute significantly to oxygen transfer in a diffused aeration system. In the present study, liquid-film-forming apparatus is successfully developed on a laboratory scale to improve considerably the surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d8cc63d4951438d998faf2a187317a
https://doi.org/10.1080/09593332808618813
https://doi.org/10.1080/09593332808618813
Autor:
Masao Ukita, Hua Zhu, Takaya Higuchi, Masahiko Sekine, Tsuyoshi Imai, Zhenjia Zhang, Kousuke Tani
Publikováno v:
Journal of Water and Environment Technology. 5:57-69
Surface transfer and bubble transfer both contribute significantly to oxygen transfer in a conventional aeration system. However, bubble transfer plays the primary role of oxygen transfer. In the present study, the mere surface transfer is replaced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29d112fad07a1f00f8ffc51eb2dd2a03
https://doi.org/10.2965/jwet.2007.57
https://doi.org/10.2965/jwet.2007.57
Autor:
Tomohiro Kitamura, Shuichi Ohuchida, Keiji Wakabayashi, Kousuke Tani, Kaoru Kobayashi, Takayuki Maruyama, Michiyoshi Kobayashi, Takashi Sugimura, Masaki Itoh, Tetsuo Noda
Publikováno v:
Cancer Science. 94:618-621
Previous studies have shown that prostaglandin E(2) (PGE(2)) is involved in intestinal carcinogenesis through its binding to the PGE(2) receptor subtypes EP(1) and EP(4) and activation of downstream pathways. ONO-8711 and ONO-AE2-227, prostaglandin E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b441420b1b7d257813fa73ae3821de0
https://doi.org/10.1111/j.1349-7006.2003.tb01492.x
https://doi.org/10.1111/j.1349-7006.2003.tb01492.x