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Fc-optimized NKG2D-Fc constructs induce NK cell antibody-dependent cellular cytotoxicity against breast cancer cells independently of HER2/neu expression status.

Autor: Raab S; Department of Hematology and Oncology, Eberhard Karls University, D-72076 Tuebingen, Germany; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, D-69120 Heidelberg, Germany;, Steinbacher J; Department of Hematology and Oncology, Eberhard Karls University, D-72076 Tuebingen, Germany; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, D-69120 Heidelberg, Germany;, Schmiedel BJ; Department of Hematology and Oncology, Eberhard Karls University, D-72076 Tuebingen, Germany; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, D-69120 Heidelberg, Germany;, Kousis PC; Department of Hematology and Oncology, Eberhard Karls University, D-72076 Tuebingen, Germany; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, D-69120 Heidelberg, Germany;, Steinle A; Institute for Molecular Medicine, Goethe University, D-60590 Frankfurt am Main, Germany; and., Jung G; Department of Immunology, Eberhard Karls University, D-72076 Tuebingen, Germany., Grosse-Hovest L; Department of Immunology, Eberhard Karls University, D-72076 Tuebingen, Germany., Salih HR; Department of Hematology and Oncology, Eberhard Karls University, D-72076 Tuebingen, Germany; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, D-69120 Heidelberg, Germany; Helmut.Salih@med.uni-tuebingen.de.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Oct 15; Vol. 193 (8), pp. 4261-72. Date of Electronic Publication: 2014 Sep 12.

Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.

Autor: Xu K; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Usary J; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Kousis PC; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Prat A; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Wang DY; The Campbell Family Cancer Research Institute and Surgical Oncology Princess Margaret Hospital, and the Department of General Surgery, University Health Network, Toronto, ON M5S 1A1, Canada., Adams JR; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada., Wang W; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Loch AJ; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Deng T; Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, ON M5S 1A1, Canada., Zhao W; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Cardiff RD; Center for Comparative Medicine, University of California, Davis, CA 95616, USA., Yoon K; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Gaiano N; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Ling V; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada; Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Beyene J; Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Zacksenhaus E; Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, ON M5S 1A1, Canada., Gridley T; Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA., Leong WL; The Campbell Family Cancer Research Institute and Surgical Oncology Princess Margaret Hospital, and the Department of General Surgery, University Health Network, Toronto, ON M5S 1A1, Canada., Guidos CJ; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A1, Canada., Perou CM; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Egan SE; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada; The Campbell Family Cancer Research Institute and Surgical Oncology Princess Margaret Hospital, and the Department of General Surgery, University Health Network, Toronto, ON M5S 1A1, Canada. Electronic address: segan@sickkids.ca.

Publikováno v: Cancer cell [Cancer Cell] 2012 May 15; Vol. 21 (5), pp. 626-641.

Functions of notch signaling in the immune system: consensus and controversies.

Autor: Yuan JS; Hospital for Sick Children Research Institute, Department of Immunology, University of Toronto, Ontario, Canada., Kousis PC, Suliman S, Visan I, Guidos CJ

Publikováno v: Annual review of immunology [Annu Rev Immunol] 2010; Vol. 28, pp. 343-65.