Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kousik Sundararajan"'
Autor:
Kousik Sundararajan, Aaron F. Straight
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Eukaryotes segregate their chromosomes during mitosis and meiosis by attaching chromosomes to the microtubules of the spindle so that they can be distributed into daughter cells. The complexity of centromeres ranges from the point centromeres of yeas
Externí odkaz:
https://doaj.org/article/3935816640084af29a37c250a691398b
Autor:
Steven Boeynaems, X. Rosa Ma, Vivian Yeong, Garrett M. Ginell, Jian-Hua Chen, Jacob A. Blum, Lisa Nakayama, Anushka Sanyal, Adam Briner, Delphi Van Haver, Jarne Pauwels, Axel Ekman, H. Broder Schmidt, Kousik Sundararajan, Lucas Porta, Keren Lasker, Carolyn Larabell, Mirian A. F. Hayashi, Anshul Kundaje, Francis Impens, Allie Obermeyer, Alex S. Holehouse, Aaron D. Gitler
Positively charged repeat peptides are emerging as key players in neurodegenerative diseases. These peptides can perturb diverse cellular pathways but a unifying framework for how such promiscuous toxicity arises has remained elusive. We used mass-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013c06175ee5e3e890d98431771b7dc9
https://doi.org/10.1101/2023.03.09.531820
https://doi.org/10.1101/2023.03.09.531820
Autor:
Annie Maslan, Nicolas Altemose, Reet Mishra, Jeremy Marcus, Lucy D. Brennan, Kousik Sundararajan, Gary Karpen, Aaron F. Straight, Aaron Streets
We recently developed Directed Methylation with Long-read sequencing (DiMeLo-seq) to map protein-DNA interactions genome wide. DiMeLo-seq maps multiple interaction sites on single DNA molecules, profiles protein binding in the context of endogenous D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffde2d435dc5293faeba9f1a4dceadf9
https://doi.org/10.1101/2022.07.03.498618
https://doi.org/10.1101/2022.07.03.498618
Autor:
Charles Limouse, Kelsey A. Fryer, Kousik Sundararajan, Owen K. Smith, Aaron F. Straight, Nicole A. Teran, Rebecca Heald
Publikováno v:
Genome Research. 31:958-967
Centromeres play an essential function in cell division by specifying the site of kinetochore formation on each chromosome for mitotic spindle attachment. Centromeres are defined epigenetically by the histone H3 variant CEntromere Protein A (CENP-A).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522d2caf782581e8adade75eea483002
https://doi.org/10.1101/gr.267781.120
https://doi.org/10.1101/gr.267781.120
Autor:
Allison K. Daitch, Benjamin C. Orsburn, Zan Chen, Laura Alvarez, Colten D. Eberhard, Kousik Sundararajan, Rilee Zeinert, Dale F Kreitler, Jean Jakoncic, Peter Chien, Felipe Cava, Sandra B. Gabelli, Namandjé N. Bumpus, Erin D. Goley
Proper regulation of the bacterial cell envelope is critical for cell survival. Identification and characterization of enzymes that maintain cell envelope homeostasis is crucial, as they can be targets for effective antibiotics. In this study, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9244b78693a35610416404b647f67be
https://doi.org/10.1101/2022.04.12.488081
https://doi.org/10.1101/2022.04.12.488081
Autor:
Allison K. Daitch, Benjamin C. Orsburn, Zan Chen, Laura Alvarez, Colten D. Eberhard, Kousik Sundararajan, Rilee Zeinert, Dale F. Kreitler, Jean Jakoncic, Peter Chien, Felipe Cava, Sandra B. Gabelli, Erin D. Goley
Publikováno v:
Current Biology. 33:228-240.e7
Proper regulation of the bacterial cell envelope is critical for cell survival. Identification and characterization of enzymes that maintain cell envelope homeostasis is crucial, as they can be targets for effective antibiotics. In this study, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90794730fae7f7134d214848c1b1195
https://doi.org/10.1016/j.cub.2022.11.037
https://doi.org/10.1016/j.cub.2022.11.037
Autor:
Karolin Luger, Keda Zhou, Magdalena Gebala, Dustin Woods, Kousik Sundararajan, Garrett Edwards, Daniel Krzizike, Jeff Wereszczynski, Aaron Straight
Publikováno v:
Nature structuralmolecular biology. 29(4)
The histone variant CENP-A is the epigenetic determinant for the centromere, where it is interspersed with canonical H3 to form a specialized chromatin structure that nucleates the kinetochore. How nucleosomes at the centromere arrange into higher or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557de3e9cda996f15bd36a9d8b706305
https://pubmed.ncbi.nlm.nih.gov/35422519
https://pubmed.ncbi.nlm.nih.gov/35422519
Autor:
Nicolas, Altemose, Annie, Maslan, Owen K, Smith, Kousik, Sundararajan, Rachel R, Brown, Reet, Mishra, Angela M, Detweiler, Norma, Neff, Karen H, Miga, Aaron F, Straight, Aaron, Streets
Publikováno v:
Nature methods. 19(6)
Studies of genome regulation routinely use high-throughput DNA sequencing approaches to determine where specific proteins interact with DNA, and they rely on DNA amplification and short-read sequencing, limiting their quantitative application in comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17910fcf950a5e9b627f66759b444696
https://pubmed.ncbi.nlm.nih.gov/35396487
https://pubmed.ncbi.nlm.nih.gov/35396487
Autor:
Annie Maslan, Kousik Sundararajan, Neff N, Owen K. Smith, Brown Rr, Detweiler Am, Aaron F. Straight, Aaron M. Streets, Karen H. Miga, Nicolas Altemose
Molecular studies of genome regulation often rely on the ability to map where specific proteins interact with genomic DNA. Existing techniques for mapping protein-DNA interactions genome-wide rely on DNA amplification methods followed by sequencing w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56d3366be55442971dc7511aff285409
https://doi.org/10.1101/2021.07.06.451383
https://doi.org/10.1101/2021.07.06.451383
Autor:
Kousik Sundararajan, Karolin Luger, Aaron F. Straight, Garrett B. Edwards, Magdalena Gebala, Keda Zhou, Krzizike D, Jeffery M. Wereszczynski, Dustin C. Woods
The histone variant CENP-A is the epigenetic determinant for the centromere, where it is interspersed with canonical H3 to form a specialized chromatin structure that nucleates the kinetochore. The arrangement of nucleosomes at the centromere into hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad607cf2e286c230efe390d1af53eb08
https://doi.org/10.1101/2021.06.14.448351
https://doi.org/10.1101/2021.06.14.448351