Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Koushi Ieki"'
Autor:
Shintaro Suzuki, Koushi Ieki, Satoshi Matsukura, Masatsugu Kurokawa, Miho Odaka, Tetsuya Homma, Mitsuru Adachi, Munehiro Yamaguchi, Shin Watanabe, Yoshitaka Yamamoto
Publikováno v:
Chinese Journal of Cancer Research. 23:232-235
A 79-year-old man was diagnosed as stage IV colon cancer and treated with a modified FOLFOX6 (mFOLFOX6) regimen. On the 12th cycle, we observed erythema and dyspnea. Radiographs showed ground grass opacities. Blood tests showed elevated levels of eos
Autor:
Shin Watanabe, Miho Odaka, Shintaro Suzuki, Hiroko Takeuchi, Koushi Ieki, Masayuki Sato, Munehiro Yamaguchi, Masatsugu Kurokawa, Tetsuya Homma, Mio Kawaguchi, Satoshi Matsukura, Mitsuru Adachi
Publikováno v:
International Archives of Allergy and Immunology. 155:12-20
Background: Interleukin (IL)-33, a new member of the IL-1 cytokine family, has been recognized as a key cytokine that enhances T helper 2-balanced immune regulation through its receptor ST2; however, the function and relationship of the IL-33 and ST2
Autor:
Mitsuru Adachi, Miho Odaka, Satoshi Matsukura, Tsukasa Ohnishi, Shin Watanabe, Tetsuya Homma, Shintaro Suzuki, Takashi Hirose, Mio Kawaguchi, Koushi Ieki, Masayuki Sato, Teruaki Kimura, Robert P. Schleimer, Masatsugu Kurokawa
Publikováno v:
International Archives of Allergy and Immunology. 152:9-17
Background: CCL5/RANTES contributes to prolonged eosinophilic inflammation and asthma exacerbation after a viral infection. We studied the mechanism of CCL5 expression using viral product double-stranded RNA (dsRNA), a ligand of Toll-like receptor 3
Autor:
Tsuyoshi Kasama, Mio Kawaguchi, Mitsuru Adachi, Shin Watanabe, Hiroko Takeuchi, Miho Odaka, Robert P. Schleimer, Hideki Kuga, Tetsuya Homma, Shintaro Suzuki, Koushi Ieki, Fumio Kokubu, Kyoko Nohtomi, Masatsugu Kurokawa, Satoshi Matsukura
Publikováno v:
International Archives of Allergy and Immunology. 143:84-88
Background: Airway smooth muscle (ASM) cells may contribute to the pathogenesis of asthma including airway inflammation and remodeling. We focused our study on the regulation of chemokine expression by cytokines and analyzed the mechanisms of eotaxin
Autor:
Satoshi Matsukura, Koushi Ieki, Mio Kawaguchi, Shintaro Suzuki, Shin Watanabe, Tetsuya Homma, Hiroko Takeuchi, Miho Odaka, Hideki Kuga, Masatsugu Kurokawa, Kyoko Nohtomi, Mitsuru Adachi, Fumio Kokubu
Publikováno v:
International Archives of Allergy and Immunology. 143:80-83
Background: We hypothesized that synthetic double-stranded (ds)RNA may mimic viral infection and reported that dsRNA stimulates expression of inflammatory chemokines through a receptor of dsRNA Toll-like receptor (TLR) 3 in airway epithelial cells. I
Autor:
Miho Odaka, Hideki Kuga, Mio Kawaguchi, Koushi Ieki, S. Suzuki, Shin Watanabe, Tsuyoshi Kasama, Fumio Kokubu, Masatsugu Kurokawa, Hiroko Takeuchi, Satoshi Matsukura, Mitsuru Adachi
Publikováno v:
Clinical Experimental Allergy. 36:1049-1062
Background We hypothesized that synthetic double-stranded (ds)RNA may mimic viral infection and induce expression of genes related to inflammation in airway epithelial cells. Objective We analysed what gene was up-regulated by synthetic dsRNA poly I
Autor:
Mitsuru Adachi, S. Suzuki, Mio Kawaguchi, Koushi Ieki, Cristiana Stellato, Fumio Kokubu, Satoshi Matsukura, Miho Odaka, Hideki Kuga, Robert P. Schleimer, Hiroko Takeuchi, Shin Watanabe
Publikováno v:
Journal of Allergy and Clinical Immunology. 111:1337-1344
Background: Eotaxin is a chemokine that binds with high affinity and specificity to the chemokine receptor CCR3 and plays an important role in the pathogenesis of allergic disease. Objective: We studied the regulation of eotaxin expression by the T H
Autor:
Masatsugu Kurokawa, Fumio Kokubu, Hiroko Takeuchi, Kyoko Notomi, Robert P. Schleimer, Satoshi Matsukura, Koushi Ieki, Mio Kawaguchi, Shintaro Suzuki, Shin Watanabe, Tetsuya Homma
Publikováno v:
International archives of allergy and immunology. 161
Background: Viral infection can exacerbate asthma by inducing the accumulation of inflammatory cells in the airway. We have previously reported that double-stranded RNA (dsRNA), a viral product and ligand of the Toll-like receptor-3 (TLR3), activates
Autor:
Mio Kawaguchi, Shin Watanabe, Miho Odaka, S. Suzuki, Tetsuya Homma, Hiroko Takeuchi, Satoshi Matsukura, Mitsuru Adachi, Koushi Ieki, Takashi Hirose, Masatsugu Kurokawa, Shau Ku Huang, Masayuki Sato, Satoshi Konno
Publikováno v:
International archives of allergy and immunology. 149
Background: Osteopontin (OPN) contributes to the development of T helper 1 (Th1)-mediated immunity and Th1-associated diseases. However, the role of OPN in bronchial asthma is unclear. Corticosteroids reduce airway inflammation, as reflected by the l
Autor:
Masatsugu Kurokawa, Masayuki Sato, Tetsuya Homma, Mio Kawaguchi, Hiroko Takeuchi, Shintaro Suzuki, Satoshi Matsukura, Tohru Aruga, Shin Watanabe, Fumio Kokubu, Miho Odaka, Koushi Ieki, Kenji Dohi, Mitsuru Adachi
Publikováno v:
International archives of allergy and immunology. 146
Background: Oxidants including reactive oxygen species have been indicated to play an important role in the pathogenesis of asthma. Objective: We investigated oxidative status in patients with acute exacerbations of asthma and evaluated the therapeut