Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Kousaku, Ohno"'
Autor:
Masamitsu Maekawa, Isamu Jinnoh, Aya Narita, Takashi Iida, Daisuke Saigusa, Anna Iwahori, Hiroshi Nittono, Torayuki Okuyama, Yoshikatsu Eto, Kousaku Ohno, Peter T. Clayton, Hiroaki Yamaguchi, Nariyasu Mano
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2074-2081 (2019)
Niemann-Pick disease type C (NPC) is an autosomal recessive disorder characterized by progressive nervous degeneration. Because of the diversity of clinical symptoms and onset age, the diagnosis of this disease is difficult. Therefore, biomarker test
Externí odkaz:
https://doaj.org/article/3811ce45480e4dc0876b5ae498134eca
Autor:
Kousaku Ohno, Lluis Samaranch, Piotr Hadaczek, John R. Bringas, Philip C. Allen, Vivek Sudhakar, Diane E. Stockinger, Christopher Snieckus, Michael V. Campagna, Waldy San Sebastian, Jerusha Naidoo, Haifeng Chen, John Forsayeth, Ernesto A. Salegio, Granger G.C. Hwa, Krystof S. Bankiewicz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 47-54 (2019)
Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates. Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast agent, enabled real-time visualization of infusions delivered either via
Externí odkaz:
https://doaj.org/article/5a819b72674d4e9490c437bdab03d8bd
Autor:
Tomoya Kawazoe, Toshiyuki Yamamoto, Aya Narita, Kousaku Ohno, Kaori Adachi, Eiji Nanba, Atsuko Noguchi, Tsutomu Takahashi, Masamitsu Maekawa, Yoshikatsu Eto, Masafumi Ogawa, Miho Murata, Yuji Takahashi
Publikováno v:
BMC Neurology, Vol 18, Iss 1, Pp 1-6 (2018)
Abstract Background Niemann-Pick disease type C (NPC) is a lysosomal storage disorder with severe prognosis. Disease-specific therapy is crucial to prevent disease progression; however, diagnosing NPC is quite difficult because of remarkably variable
Externí odkaz:
https://doaj.org/article/0674b543366840c7947d2e7ab6ab8408
Autor:
Yuta Tanaka, Yoichi Ishitsuka, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Muneaki Matsuo, Katsumi Higaki, Kousaku Ohno, Tetsumi Irie
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 1, Iss C, Pp 19-30 (2014)
Hydroxypropyl-β-cyclodextrin (HPBCD) is an attractive drug candidate against Niemann–Pick Type C (NPC) disease. However, the safety of HPBCD treatment for NPC patients remains to be elucidated. In this study, we examined the acute toxicity of HPBC
Externí odkaz:
https://doaj.org/article/cb4e876948c84efb9c820dd9a8479505
Autor:
Ryo Suzuki, Atsushi Tanaka, Toshiharu Matsui, Tetsuki Gunji, Jun Tohyama, Aya Narita, Eiji Nanba, Kousaku Ohno
Publikováno v:
Case Reports in Pediatrics, Vol 2017 (2017)
Externí odkaz:
https://doaj.org/article/85c991af5f684f94a54226f24a487026
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 4 (2016)
BackgroundThe efficacy of P2Y12 inhibition for the prevention of cardiovascular events in patients with peripheral arterial disease (PAD) has been established. However, the therapeutic effects on ischemic limb complications are less clear. Accordingl
Externí odkaz:
https://doaj.org/article/07ba9bcbbc5846b59be784638a481f1f
Publikováno v:
Journal of Pharmacological Sciences, Vol 106, Iss 3, Pp 485-491 (2008)
The cholinergic system plays an important role in regulation of arousal and REM sleep. In the present study, we showed that a muscarinic receptor agonist, carbachol (CCh), activates almost 20% of orexin-producing neurons (orexin neurons), which play
Externí odkaz:
https://doaj.org/article/556b775eb53a46abac09c4183b8c9e25
Autor:
Hiroko Okuda, Atsuko Noguchi, Hatasu Kobayashi, Daiki Kondo, Kouji H Harada, Shohab Youssefian, Hirotomo Shioi, Risako Kabata, Yuki Domon, Kazufumi Kubota, Yutaka Kitano, Yasunori Takayama, Toshiaki Hitomi, Kousaku Ohno, Yoshiaki Saito, Takeshi Asano, Makoto Tominaga, Tsutomu Takahashi, Akio Koizumi
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154827 (2016)
Painful peripheral neuropathy has been correlated with various voltage-gated sodium channel mutations in sensory neurons. Recently Nav1.9, a voltage-gated sodium channel subtype, has been established as a genetic influence for certain peripheral pain
Externí odkaz:
https://doaj.org/article/806648927d904f768752537abf236d38
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154661 (2016)
Platelets play pivotal roles in both hemostasis and thrombosis. Although models of intravital platelet imaging are available for thrombosis studies in mice, few are available for rat studies. The present effort aimed to generate fluorescent platelets
Externí odkaz:
https://doaj.org/article/31ef4768d63f40569af20bd652e91259
Autor:
Ryo Suzuki, Atsushi Tanaka, Toshiharu Matsui, Tetsuki Gunji, Jun Tohyama, Aya Nairita, Eiji Nanba, Kousaku Ohno
Publikováno v:
Case Reports in Pediatrics, Vol 2015 (2015)
Niemann-Pick disease type C (NPC) is a rare progressive neurodegenerative disorder, often with onset after normal early childhood development. Juvenile onset NPC patients slowly develop cerebellar symptoms and cognitive impairment and often experienc
Externí odkaz:
https://doaj.org/article/9090c85331d34e5a8b85c987bc8ecd5d