Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Kourosh Saeb Parsy"'
Autor:
Valerie Coppard, Grisha Szep, Zoya Georgieva, Sarah K. Howlett, Lorna B. Jarvis, Daniel B. Rainbow, Ondrej Suchanek, Edward J. Needham, Hani S. Mousa, David K. Menon, Felix Feyertag, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Joanne L. Jones
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
As the dimensionality, throughput and complexity of cytometry data increases, so does the demand for user-friendly, interactive analysis tools that leverage high-performance machine learning frameworks. Here we introduce FlowAtlas: an interactive web
Externí odkaz:
https://doaj.org/article/38abc65bbc2440418eb7722db7fcaa14
Publikováno v:
Engineering, Vol 32, Iss , Pp 29-40 (2024)
Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor organs. Extended criteria donor (ECD) liver grafts are increasingly utilized in clinical practice to mitigate this ch
Externí odkaz:
https://doaj.org/article/bcf1281db7454eb49806925f72ab4480
Autor:
Akimichi Inaba, Zewen Kelvin Tuong, Tian X. Zhao, Andrew P. Stewart, Rebeccah Mathews, Lucy Truman, Rouchelle Sriranjan, Jane Kennet, Kourosh Saeb-Parsy, Linda Wicker, Frank Waldron-Lynch, Joseph Cheriyan, John A. Todd, Ziad Mallat, Menna R. Clatworthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Dysfunction of interleukin-10 producing regulatory B cells has been associated with the pathogenesis of autoimmune diseases, but whether regulatory B cells can be therapeutically induced in humans is currently unknown. Here we demonstrate th
Externí odkaz:
https://doaj.org/article/733547fe76a040a4be8f3da2878d86c9
Autor:
Philip S. Robinson, Laura E. Thomas, Federico Abascal, Hyunchul Jung, Luke M. R. Harvey, Hannah D. West, Sigurgeir Olafsson, Bernard C. H. Lee, Tim H. H. Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A. Sanders, Stefanie V. Lensing, Simon J. A. Buczacki, Rogier ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J. Campbell, Iñigo Martincorena, Julian R. Sampson, Michael R. Stratton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Inherited mutations in MUTYH have been shown to predispose patients to colorectal cancers. Here, the authors show that MUTYH mutations lead to an increased somatic base substitution mutation rate in normal intestinal epithelial cells, which is the li
Externí odkaz:
https://doaj.org/article/c14b563faf084d9f9abf9b953d1b62bf
Autor:
Thomas Simon, Joseph Kirk, Nikola Dolezalova, Mélanie Guyot, Clara Panzolini, Alexandre Bondue, Julien Lavergne, Sandrine Hugues, Nicolas Hypolite, Kourosh Saeb-Parsy, Justin Perkins, Eric Macia, Arun Sridhar, Margriet J. Vervoordeldonk, Nicolas Glaichenhaus, Matteo Donegá, Philippe Blancou
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The magnitude of innate inflammatory immune responses is dependent on interactions between peripheral neural and immune cells. In particular, a cholinergic anti-inflammatory pathway (CAP) has been identified in the spleen whereby noradrenaline (NA) r
Externí odkaz:
https://doaj.org/article/4272537ee57347afa7f6a51ea23771d1
Autor:
Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The E3 ubiquitin ligases RNF43/ZNRF3 are often mutated in cancer but their precise contribution to liver disease is unknown. Here, the authors show that RNF43/ZNRF3 alterations predispose to liver cancer by controlling the differentiation and lipid m
Externí odkaz:
https://doaj.org/article/b340f59562d343c38a3ffe78a2def2d3
Autor:
Lorna B. Jarvis, Daniel B. Rainbow, Valerie Coppard, Sarah K. Howlett, Zoya Georgieva, Jessica L. Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T. Grist, Alasdair J. Coles, Hani S. Mousa, Stefano Pluchino, Krishnaa T. Mahbubani, Julian L. Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S. Wicker, Joanne L. Jones
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jarvis et al demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A)-driven acquisition of CD73 expression, which along with CD39, ena
Externí odkaz:
https://doaj.org/article/45140660645e4b33867eb3d5efef93f6
Autor:
Anja V. Gruszczyk, Alva M. Casey, Andrew M. James, Hiran A. Prag, Nils Burger, Georgina R. Bates, Andrew R. Hall, Fay M. Allen, Thomas Krieg, Kourosh Saeb-Parsy, Michael P. Murphy
Publikováno v:
Redox Biology, Vol 54, Iss , Pp 102368- (2022)
Cell models of cardiac ischemia-reperfusion (IR) injury are essential to facilitate understanding, but current monolayer cell models poorly replicate the in vivo IR injury that occurs within a three-dimensional tissue. Here we show that this is for t
Externí odkaz:
https://doaj.org/article/6473c0db19b24a889ec6d16509ca913e
Autor:
Rute A Tomaz, Ekaterini D Zacharis, Fabian Bachinger, Annabelle Wurmser, Daniel Yamamoto, Sandra Petrus-Reurer, Carola M Morell, Dominika Dziedzicka, Brandon T Wesley, Imbisaat Geti, Charis-Patricia Segeritz, Miguel C de Brito, Mariya Chhatriwala, Daniel Ortmann, Kourosh Saeb-Parsy, Ludovic Vallier
Publikováno v:
eLife, Vol 11 (2022)
Production of large quantities of hepatocytes remains a major challenge for a number of clinical applications in the biomedical field. Directed differentiation of human pluripotent stem cells (hPSCs) into hepatocyte-like cells (HLCs) provides an adva
Externí odkaz:
https://doaj.org/article/07a94c8ea33a4c4d9ca24e8d7b3c1339
Autor:
Sandra Petrus-Reurer, Marco Romano, Sarah Howlett, Joanne Louise Jones, Giovanna Lombardi, Kourosh Saeb-Parsy
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
In this Review, Petrus-Reurer et al describe the roles of both innate and adaptive immune responses in allogeneic graft rejection, in addition to discuss how such responses are determined by the cellular therapy of interest. They also describe the ra
Externí odkaz:
https://doaj.org/article/859349b557dc4c4183605d19cd5cdb44