Overexpression of HIF-1α contributes to melphalan resistance in multiple myeloma cells by activation of ERK1/2, Akt, and NF-κB.

Autor: Tsubaki M; Division of Pharmacotherapy, Faculty of Pharmacy, Kindai University, Kowakae, Higashi-Osaka, Japan., Takeda T; Division of Pharmacotherapy, Faculty of Pharmacy, Kindai University, Kowakae, Higashi-Osaka, Japan., Tomonari Y; Division of Pharmacotherapy, Faculty of Pharmacy, Kindai University, Kowakae, Higashi-Osaka, Japan., Koumoto YI; Division of Pharmacotherapy, Faculty of Pharmacy, Kindai University, Kowakae, Higashi-Osaka, Japan., Imano M; Department of Surgery, Faculty of Medicine, Kindai University, Osakasayama, Osaka, Japan., Satou T; Department of Pathology, Faculty of Medicine, Kindai University, Osakasayama, Osaka, Japan., Nishida S; Division of Pharmacotherapy, Faculty of Pharmacy, Kindai University, Kowakae, Higashi-Osaka, Japan. nishida@phar.kindai.ac.jp.

Publikováno v: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2019 Jan; Vol. 99 (1), pp. 72-84. Date of Electronic Publication: 2018 Oct 23.

The MIP-1α autocrine loop contributes to decreased sensitivity to anticancer drugs.

Autor: Tsubaki M; Faculty of Pharmacy, Division of Pharmacotherapy, Kindai University, Kowakae, Higashi-Osaka, Japan., Takeda T; Faculty of Pharmacy, Division of Pharmacotherapy, Kindai University, Kowakae, Higashi-Osaka, Japan., Tomonari Y; Faculty of Pharmacy, Division of Pharmacotherapy, Kindai University, Kowakae, Higashi-Osaka, Japan., Mashimo K; Faculty of Pharmacy, Division of Pharmacotherapy, Kindai University, Kowakae, Higashi-Osaka, Japan.; Department of Pharmacy, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan., Koumoto YI; Faculty of Pharmacy, Division of Pharmacotherapy, Kindai University, Kowakae, Higashi-Osaka, Japan., Hoshida S; Faculty of Pharmacy, Division of Pharmacotherapy, Kindai University, Kowakae, Higashi-Osaka, Japan., Itoh T; Faculty of Agriculture, Department of Food Science and Nutrition, Kindai University, Nara, Nara, Japan., Imano M; Faculty of Medicine, Department of Surgery, Kindai University, Osakasayama, Osaka, Japan., Satou T; Faculty of Medicine, Department of Pathology, Kindai University, Osakasayama, Osaka, Japan., Sakaguchi K; Department of Pharmacy, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan., Nishida S; Faculty of Pharmacy, Division of Pharmacotherapy, Kindai University, Kowakae, Higashi-Osaka, Japan.

Publikováno v: Journal of cellular physiology [J Cell Physiol] 2018 May; Vol. 233 (5), pp. 4258-4271. Date of Electronic Publication: 2017 Nov 16.