Výsledky vyhledávání - "Koumbourlis, A."

Akademický článek

Time to re-set our thinking about airways disease: lessons from history, the resurgence of chronic bronchitis / PBB and modern concepts in microbiology

Autor: Mark L. Everard, Kostas Priftis, Anastassios C. Koumbourlis, Michael D. Shields

Publikováno v: Frontiers in Pediatrics, Vol 12 (2024)

In contrast to significant declines in deaths due to lung cancer and cardiac disease in Westernised countries, the mortality due to ‘chronic obstructive pulmonary disease’ (COPD) has minimally changed in recent decades while ‘the incidence of b

Externí odkaz: https://doaj.org/article/e99b52633c964d109a44ccbfeb1ad8c8

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Akademický článek

Therapeutic beta-lactam dosages and broad-spectrum antibiotics are associated with reductions in microbial richness and diversity in persons with cystic fibrosis

Autor: Andrea Hahn, Aszia Burrell, Hollis Chaney, Iman Sami, Anastassios C. Koumbourlis, Robert J. Freishtat, Keith A. Crandall, Edith T. Zemanick

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Persons with cystic fibrosis (PwCF) suffer from pulmonary exacerbations (PEx) related in part to lung infection. While higher microbial diversity is associated with higher lung function, the data on the impact of short-term antibiotics on ch

Externí odkaz: https://doaj.org/article/2d0a24eb602c491eaff85195da292987

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Akademický článek

Bacteriophage Therapy for Pan-Drug-Resistant in Two Persons With Cystic Fibrosis

Autor: Andrea Hahn MD, MS, Iman Sami MD, Hollis Chaney MD, Anastassios C. Koumbourlis MD, MPH, Coralee Del Valle Mojica MD, MPH, Claire Cochrane BA, Benjamin K. Chan PhD, Jonathan L. Koff MD

Publikováno v: Journal of Investigative Medicine High Impact Case Reports, Vol 11 (2023)

Cystic fibrosis (CF) is an important monogenic disease that affects more than 70 000 people worldwide. Defects of the CF transmembrane conductance regulator gene lead to dehydrated viscous secretions that result in chronic bacterial colonization. Thi

Externí odkaz: https://doaj.org/article/7d520f4dab4749968edab62c0eba4335

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Akademický článek

Using metabolic potential within the airway microbiome as predictors of clinical state in persons with cystic fibrosis

Autor: Gabriella Shumyatsky, Aszia Burrell, Hollis Chaney, Iman Sami, Anastassios C. Koumbourlis, Robert J. Freishtat, Keith A. Crandall, Edith T. Zemanick, Andrea Hahn

Publikováno v: Frontiers in Medicine, Vol 9 (2023)

IntroductionPulmonary exacerbations (PEx) in persons with cystic fibrosis (CF) are primarily related to acute or chronic inflammation associated with bacterial lung infections, which may be caused by several bacteria that activate similar bacterial g

Externí odkaz: https://doaj.org/article/cccfef38dff140d5b9f5b859e8b43e5b

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