Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Kouji Hattori"'
Publikováno v:
Bioceramics Development and Applications. 1:1-4
Synthetic polymer (RADA16:PuraMatrix®) is an artificial peptide and self assembling. RADA16 is able to provide three dimensional constructs which hold mesenchy- mal stem cell (MSCs). We combined the MSCs into the polymer and fabricated MSC/RADA comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83a375f975f44b60fc064db022715581
https://doi.org/10.4303/bda/d110172
https://doi.org/10.4303/bda/d110172
Autor:
Kenichi Washizuka, Yasuhiro Matsumura, Yasuyo Tomishima, Keiko Nakano, Naoko Unami, Fujiko Takamura, Takanobu Araki, Shigeo Matsui, Minoru Sakurai, Masashi Imanishi, Takao Yamamoto, Kaori Hamada, Kouji Hattori, Hitoshi Hamashima, Nobuhiro Yamamoto, Emiko Imamura, Hirofumi Ishikawa, Koji Ueshima, Yutaka Nakajima, Susumu Toda, Shinji Itou
Publikováno v:
Journal of Medicinal Chemistry. 52:3063-3072
As an extension of research conducted on beta(3)-adrenergic receptor agonists as potential drugs for treating overactive bladder (OAB), novel series containing an acylsulfonamide moiety instead of the carboxylic acid moiety were evaluated. These comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db696b5f389955fb00201a425aef2632
https://doi.org/10.1021/jm9000709
https://doi.org/10.1021/jm9000709
Autor:
Masashi, Imanishi, Yasuyo, Tomishima, Shinji, Itou, Hitoshi, Hamashima, Yutaka, Nakajima, Kenichi, Washizuka, Minoru, Sakurai, Shigeo, Matsui, Emiko, Imamura, Koji, Ueshima, Takao, Yamamoto, Nobuhiro, Yamamoto, Hirofumi, Ishikawa, Keiko, Nakano, Naoko, Unami, Kaori, Hamada, Yasuhiro, Matsumura, Fujiko, Takamura, Kouji, Hattori
Publikováno v:
Journal of Medicinal Chemistry. 51:1925-1944
A novel class of biphenyl analogues containing a benzoic acid moiety based on lead compound 8i have been identified as potent and selective human beta 3 adrenergic receptor (beta 3-AR) agonists with good oral bioavailability and long plasma half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3df2218288fe87564bacbf9f841e0ed
https://doi.org/10.1021/jm701324c
https://doi.org/10.1021/jm701324c
Autor:
Satoshi Miyamoto, Naoyuki Masuda, Wataru Hamaguchi, Shigetoshi Kikuchi, Fumie Narazaki, Takuma Mihara, Yasushi Amano, Ryushi Seo, Hiroyuki Moriguchi, Kouji Hattori, Yasuhiro Shiina
Publikováno v:
Bioorganicmedicinal chemistry. 23(13)
We synthesized several biaryl derivatives as PDE10A inhibitors to prevent phototoxicity of 2-[4-({[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]quinoline (1) and found that the energy difference between the energy-minimized conformatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05361ad8b6571427446864c695c6d23
https://pubmed.ncbi.nlm.nih.gov/25960322
https://pubmed.ncbi.nlm.nih.gov/25960322
Autor:
Noriaki Maeda, Hidetsugu Murai, Kouji Hattori, Osamu Okitsu, Mie Nishio, Akira Tanaka, Yasunori Nagakura, Jiro Seki, Kiyoshi Taniguchi, Seiichiro Tabuchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4861-4864
The synthesis and biological activity of novel derivatives of our previously reported IP receptor agonist FR181157 is described. SAR studies to replace the cyclohexene-linker of FR181157 led to the discovery of compound 1i (FR207845) as a potent non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4efd82720f835265bae5de973b766e4
https://doi.org/10.1016/j.bmcl.2006.06.076
https://doi.org/10.1016/j.bmcl.2006.06.076
Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5
Autor:
Jiro Seki, Kiyoshi Taniguchi, Akira Tanaka, Kouji Hattori, Hisashi Takasugi, Fujiko Takamura, Mie Nishio
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4475-4478
A metabolism study of FK788 (2) led to the discovery of new diphenylcarbamoyl derivatives as prostacyclin mimetics without the PG skeleton. We designed and evaluated PGI2 mimetics based on blocking the main metabolic pathway of FK788. The new compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721d7bc78a2411b0ca63044f84db057c
https://doi.org/10.1016/j.bmcl.2006.06.033
https://doi.org/10.1016/j.bmcl.2006.06.033
Autor:
Kouji Hattori, Kayoko Mihara, Takayoshi Kinoshita, Kazunori Kamijo, Hirofumi Yamamoto, Yoshiyuki Kido, Hiroshi Miyake, Masaichi Warizaya, Junya Ishida, Nobuya Matsuoka, Akinori Iwashita, Kenji Murano, Mitsuru Ohkubo
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:1378-1390
We disclose herein our efforts aimed at discovery of selective PARP-1 and PARP-2 inhibitors. We have recently discovered several novel classes of quinazolinones, quinazolidinones, and quinoxalines as potent PARP-1 inhibitors, which may represent attr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c509e2b1109ed4caaeed6c285329dccd
https://doi.org/10.1016/j.bmc.2005.09.061
https://doi.org/10.1016/j.bmc.2005.09.061
Autor:
Kouji Hattori
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 64:923-933
Prostacyclin (PGI2) is primarily secreted from vascular endothelium and plays an extremely important inhibitory role in platelet aggregation and as a vasodilator in maintaining homeostatic circulation. Despite fascinating pharmacological properties,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3555fbec21d34d035356dba77bf085f
https://doi.org/10.5059/yukigoseikyokaishi.64.923
https://doi.org/10.5059/yukigoseikyokaishi.64.923
Autor:
Kouji, Hattori, Fujiko, Takamura, Akira, Tanaka, Hisashi, Takasugi, Kiyoshi, Taniguchi, Mie, Nishio, Satoshi, Koyama, Jiro, Seki, Kazuo, Sakane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3284-3287
A metabolism study of FR181157 (1) led to the discovery of new oxazole derivatives as active metabolites. The metabolite 6 with an epoxy ring exhibited high anti-aggregative potency with an IC(50) of 5.8 nM and potent binding affinity for the human r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc565e53a9c03d9516b3b2486ac467b
https://doi.org/10.1016/j.bmcl.2005.04.076
https://doi.org/10.1016/j.bmcl.2005.04.076
Autor:
Mie Nishio, Kouji Hattori, Masahide Higaki, Jiro Seki, Satoshi Koyama, Kiyoshi Taniguchi, Osamu Okitsu, Akira Tanaka, Seiichiro Tabuchi, Kazuo Sakane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3091-3095
The new classes of diphenylcarbamate derivatives with a tetrahydronaphthalene skeleton as highly potent and selective IP agonists have been discovered. The optimized diphenylcarbamate type compound FK-788: (R)-4 exhibited potent antiaggregative poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f98561b97697802f1557bf4c6b78b7
https://doi.org/10.1016/j.bmcl.2005.04.047
https://doi.org/10.1016/j.bmcl.2005.04.047