Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Kouji Fukuyama"'
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 204 (2024)
To explore the developmental processes of epileptogenesis/ictogenesis, this study determined age-dependent functional abnormalities associated with purinergic transmission in a genetic rat model (S286L-TG) of autosomal-dominant sleep-related hypermot
Externí odkaz:
https://doaj.org/article/fa80538ddb044934a44428f496ba59e9
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1619 (2024)
To explore the processes of epileptogenesis/ictogenesis, this study determined the age-dependent development of the functional abnormalities in astroglial transmission associated with pannexin1-hemichannel using a genetic rat model of autosomal domin
Externí odkaz:
https://doaj.org/article/70d19fb6156b464f9fe3992339d957d6
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1288 (2023)
Clozapine is listed as one of the most effective antipsychotics and has been approved for treating treatment-resistant schizophrenia (TRS); however, several type A and B adverse reactions, including weight gain, metabolic complications, cardiotoxicit
Externí odkaz:
https://doaj.org/article/3d78f945ecdc4322a6988347281abb3e
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 862 (2023)
Clozapine is an effective antipsychotic for the treatment of antipsychotic-resistant schizophrenia; however, specific types of A/B adverse effects and clozapine-discontinuation syndromes are also well known. To date, both the critical mechanisms of c
Externí odkaz:
https://doaj.org/article/9af9743736f44ab5a9d6c54eb3b5e6cf
Autor:
Kouji Fukuyama, Motohiro Okada
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 149, Iss , Pp 112846- (2022)
To explore developmental processes of epileptogenesis/ictogenesis and pathophysiology of carbamazepine-resistant epilepsy, we determined effects of high-frequency-oscillation (HFO) on glutamatergic tripartite-synaptic transmission, astroglial express
Externí odkaz:
https://doaj.org/article/dbd98a11f6624c0abc6bafdbbd4aa7bc
Publikováno v:
Nutrients, Vol 15, Iss 7, p 1621 (2023)
Lurasidone and quetiapine are effective atypical mood-stabilizing antipsychotics, but lurasidone and quetiapine are listed as lower-risk and high-risk for weight gain/metabolic complications, respectively. The pathophysiology of the discrepancy of me
Externí odkaz:
https://doaj.org/article/9fc70b112cc847ad86636fd9c8eac4ad
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 148, Iss , Pp 112750- (2022)
A part of atypical antipsychotics exert mood-stabilising effects via modulation of various monoamine receptors and intracellular signalling. Recent pharmacodynamic studies suggested that tripartite-synaptic transmission can be involved in pathophysio
Externí odkaz:
https://doaj.org/article/57af791bcb7e4b488db390116cd01b3f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2070 (2023)
Although a number of mood-stabilising atypical antipsychotics and antidepressants modulate serotonin type 7 receptor (5-HT7), the detailed contributions of 5-HT7 function to clinical efficacy and pathophysiology have not been fully understood. The mo
Externí odkaz:
https://doaj.org/article/9c7d235d5902437db6b16322afa0867d
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9103 (2022)
Recent pharmacological studies indicated that the modulation of tripartite-synaptic transmission plays important roles in the pathophysiology of schizophrenia, mood disorders and adverse reactions. Therefore, to explore the mechanisms underlying the
Externí odkaz:
https://doaj.org/article/543ec0e2c30e42df8f65344c7d2a22d8
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 138, Iss , Pp 111462- (2021)
The antiepileptic/anticonvulsive action of brivaracetam is considered to occur via modulation of synaptic vesicle protein 2A (SV2A); however, the pharmacological mechanisms of action have not been fully characterised. To explore the antiepileptic/ant
Externí odkaz:
https://doaj.org/article/d47ca9d03dfd46329686ba82cda602db