Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kouichi Yanagi"'
Autor:
Kouichi Yanagi, Toru Komatsu, Yuuta Fujikawa, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Tasuku Ueno, Kenjiro Hanaoka, Yasuteru Urano
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-8 (2023)
Abstract Controlling tumor-specific alterations in metabolic pathways is a useful strategy for treating tumors. The glyoxalase pathway, which metabolizes the toxic electrophile 2-methylglyoxal (MG), is thought to contribute to tumor pathology. We dev
Externí odkaz:
https://doaj.org/article/e9e6082763a849dc8de3ca821b8e7c5f
Autor:
Takayoshi Okabe, Yuka Miyake, Hirotatsu Kojima, Tetsuo Nagano, Yusuke Kimura, Shusuke Ogihara, Toru Komatsu, Tasuku Ueno, Kouichi Yanagi, Takayoshi Suzuki, Yasuteru Urano, Yukihiro Itoh, Kenjiro Hanaoka
Publikováno v:
Journal of the American Chemical Society. 142:21-26
Methyl transfer reactions play important roles in many biological phenomena, wherein the methylation cofactor S-adenosyl-l-methionine (SAM) serves as the important currency to orchestrate those reactions. We have developed a fluorescent-probe-based h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6852a4555213bdb9a887ca49551401bf
https://doi.org/10.1021/jacs.9b08698
https://doi.org/10.1021/jacs.9b08698
Autor:
Shusuke Ogihara, Takayoshi Okabe, Toru Komatsu, Yasuteru Urano, Kouichi Yanagi, Kenjiro Hanaoka, Tetsuo Nagano, Hirotatsu Kojima, Tasuku Ueno
Publikováno v:
Cell reports. 36(1)
In this study, we present a live-cell-based fluorometric coupled assay system to identify the compounds that can regulate the targeted metabolic pathways in live cells. The assay is established through targeting specific metabolic pathways and using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffc5eddd349e24ae6c22c90824459bd
https://pubmed.ncbi.nlm.nih.gov/34233188
https://pubmed.ncbi.nlm.nih.gov/34233188
Autor:
Yasuteru Urano, Kouichi Yanagi, Kenjiro Hanaoka, Takayoshi Okabe, Toru Komatsu, Hirotatsu Kojima, Tasuku Ueno, Tetsuo Nagano
Publikováno v:
SSRN Electronic Journal.
We present a live cell-based high throughput screening (HTS) system that enables the identification of compounds that have the ability to modify targeted metabolic pathways in pathogenic cells. In the assay, a specified “input” metabolite is adde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bf721bcceef8df213df91bf863ca88e
https://doi.org/10.2139/ssrn.3634812
https://doi.org/10.2139/ssrn.3634812
Autor:
Shusuke, Ogihara, Toru, Komatsu, Yukihiro, Itoh, Yuka, Miyake, Takayoshi, Suzuki, Kouichi, Yanagi, Yusuke, Kimura, Tasuku, Ueno, Kenjiro, Hanaoka, Hirotatsu, Kojima, Takayoshi, Okabe, Tetsuo, Nagano, Yasuteru, Urano
Publikováno v:
Journal of the American Chemical Society. 142(1)
Methyl transfer reactions play important roles in many biological phenomena, wherein the methylation cofactor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::522ce8fecc39de6db0c72b4d42fedea9
https://pubmed.ncbi.nlm.nih.gov/31869215
https://pubmed.ncbi.nlm.nih.gov/31869215
Autor:
Toru Komatsu, Tasuku Ueno, Takayoshi Okabe, Yusuke Kimura, Kenjiro Hanaoka, Tetsuo Nagano, Yasuteru Urano, Kouichi Yanagi, Hirotatsu Kojima, Takuya Terai
Publikováno v:
Angewandte Chemie (International ed. in English). 56(1)
We have established a coupled assay system targeting protein l-isoaspartyl methyltransferase (PIMT), a key enzyme in the metabolism of isoaspartyl peptides and proteins. The system utilizes a fluorogenic peptide probe containing an isoaspartyl residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6705c54e6aa8d741b20ff2cb5af5d220
https://pubmed.ncbi.nlm.nih.gov/27933714
https://pubmed.ncbi.nlm.nih.gov/27933714
Publikováno v:
AIJ Journal of Technology and Design. 4:47-51
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f5467ddff6672304fc1a8bb16ade15
https://doi.org/10.3130/aijt.4.47
https://doi.org/10.3130/aijt.4.47
Autor:
Eriko Nakasai, Hiroshi Tanizawa, Minani Takawaki, Kouichi Yanagita, Shin-ichi Kawakami, Takao Oka, Masaoki Tsudzuki, Takashi Bungo
Publikováno v:
The Journal of Poultry Science, Vol 50, Iss 4, Pp 321-325 (2013)
The objective of the present study was to evaluate the temperament of a native Japanese chicken breed (Tosa-Jidori) using the tonic immobility test for the detection of fearfulness. Each chick (2, 5, 10 or 15-day old) was placed on its back on a tabl
Externí odkaz:
https://doaj.org/article/5474ac493b70453192cc1f10cb51b9f7
Publikováno v:
The Journal of Poultry Science, Vol 48, Iss 2, Pp 125-129 (2011)
It is important to quantify and estimate stressful stimulation because stress appears to limit productivity and welfare in poultry. The purpose of this study is to investigate the effect of acute isolation stress (5, 10 or 30min) on the levels of blo
Externí odkaz:
https://doaj.org/article/e9501af49e4c49fcbcef38467b010075
Autor:
Takashi Bungo, Kazuki Yahata, Tomofumi Izumi, Koh-Ichi Dodo, Kouichi Yanagita, Jun-ichi Shiraishi, Yoshiyuki Ohta, Masanori Fujita
Publikováno v:
The Journal of Poultry Science, Vol 45, Iss 3, Pp 215-219 (2008)
The effects of intracerebroventricular injection of L-tryptophan on feeding behavior and the levels of brain neurotransmitters (amino acids or monoamines) were investigated in ad libitum chicks. The tryptophan treatment (3 or 6μmol) significantly in
Externí odkaz:
https://doaj.org/article/708c9404e7514395ab6cc50e55938da5