Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Kouichi Uoto"'
Autor:
Tomoyuki Tsunemi, Tomohiro Makino, Kazuo Miyazaki, Hideki Terashima, Kyoko Yamashiro, Katsushi Katayama, Maki Terakawa, Hiroaki Maeda, Kouichi Uoto, Munetada Haruyama, Ryosuke Yoshioka
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(19)
Pharmacological reactivation of the γ-globin gene for the production of fetal hemoglobin (HbF) is a promising approach for the management of β-thalassemia and sickle cell disease (SCD). We conducted a phenotypic screen in human erythroid progenitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ba426550decb5cd6a9356583181101
https://pubmed.ncbi.nlm.nih.gov/32717372
https://pubmed.ncbi.nlm.nih.gov/32717372
Autor:
Kenji Yoshikawa, Toshiharu Yoshino, Makoto Takemura, Akiyoshi Mochizuki, Toshiharu Ohta, Tsutomu Nagata, Kouichi Uoto, Yoshihiro Yokomizo, Hiroyuki Naito, Katsuhiro Kawakami, Hideyuki Kanno, Makoto Suzuki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2133-2140
We previously reported on a series of cyclohexanediamine derivatives as highly potent factor Xa inhibitors. Herein, we describe the modification of the spacer moiety to discover an alternative scaffold. Ethylenediamine derivatives possessing a substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a646e3feedd1b429071692e1d9bc059
https://doi.org/10.1016/j.bmcl.2011.01.132
https://doi.org/10.1016/j.bmcl.2011.01.132
Autor:
Eri Watanabe, Shozo Kobayashi, Ken-Ichi Yoshida, Tsuyoshi Otani, Yoshikazu Ishii, Kouichi Uoto, Masato Hata, Akikazu Ando
Publikováno v:
Medical Mycology. 48:613-621
The limited number of clinically available antifungal drugs for life-threatening fungal infections has produced an increased demand for new agents. In the course of our screening for novel antifungals, we identified aminopiperidine derivatives which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cc62f1e12b735992f87f1147adbd62
https://doi.org/10.3109/13693780903390208
https://doi.org/10.3109/13693780903390208
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:7850-7860
The design, synthesis and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitor are described. Focusing on the optimization of the heteroaryl moiety at the hydrazone with substituted phenyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4279a5b22382b2defe9b0beeab978b
https://doi.org/10.1016/j.bmc.2009.10.039
https://doi.org/10.1016/j.bmc.2009.10.039
Autor:
Hiroyuki Naito, Yoshida Keisuke, Yuuichi Sugimoto, Tsunehiko Soga, Haruko Kawato, Masaki Miyazaki, Takahiko Seki, Setsuko Fukutake, Tooru Okayama, Kouichi Uoto, Masaya Miyazaki, Masashi Aonuma, Mayumi Kitagawa
Publikováno v:
Bioorganicmedicinal chemistry. 23(10)
We have published p53-MDM2 interaction inhibitors possessing a novel dihydroimidazothiazole scaffold. Although our lead compound 1 showed strong antitumor activity with single oral administration on a xenograft model using MV4-11 cells harboring wild
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e724ca9ecbe33c6c2e563d465a7411c
https://pubmed.ncbi.nlm.nih.gov/25882531
https://pubmed.ncbi.nlm.nih.gov/25882531
Autor:
Takeshi Jimbo, Tsunehiko Soga, Motoko Nagata, Yasuyuki Takeda, Chiho Ono, Michio Iwahana, Hirofumi Terasawa, Kouichi Uoto, Noriko Tanaka, Ryo Atsumi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:3209-3215
To improve the metabolic stability of 3, which exhibited both in vitro antitumor activity and in vivo efficacy by both iv and po administration, we designed and synthesized new taxane analogues. Most of the synthetic compounds maintained excellent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be3909537e36f1c0dd2fbd5f7d0a637
https://doi.org/10.1016/j.bmcl.2004.03.109
https://doi.org/10.1016/j.bmcl.2004.03.109
Autor:
Yasuyuki, Takeda, Toshiharu, Yoshino, Kouichi, Uoto, Jun, Chiba, Takashi, Ishiyama, Michio, Iwahana, Takeshi, Jimbo, Noriko, Tanaka, Hirofumi, Terasawa, Tsunehiko, Soga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:185-190
We synthesized novel water-soluble and orally active taxane analogues, 7-deoxy-9beta-dihydro-9,10-O-acetal taxanes. Cytotoxicities of the synthetic compounds were greater than those of paclitaxel and docetaxel, especially against resistant cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7be4c16026aa2a1ce98ef20f7fc984
https://doi.org/10.1016/s0960-894x(02)00891-0
https://doi.org/10.1016/s0960-894x(02)00891-0
Autor:
Toshiharu Yoshino, Kouichi Uoto, Takeshi Jimbo, Shin Iimura, Satoru Ohsuki, Tsunehiko Soga, Jun Chiba, Michio Iwahana, Hirofumi Terasawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:407-410
To improve cytotoxicity of 10-deoxy-10-C-morpholinoethyl docetaxel analogues against various tumor cell lines including resistant cells expressing P-glycoprotein (P-gp), we modified the 7-hydroxyl group to hydrophobic groups (methoxy, deoxy, 6,7-olef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09f367001b2cd827d52f43b22d99048c
https://doi.org/10.1016/s0960-894x(00)00682-x
https://doi.org/10.1016/s0960-894x(00)00682-x
Autor:
Keiki Sato, Yasuyoshi Kawato, Hirofumi Terasawa, Y. Hirota, Kouichi Uoto, Satoru Ohsuki, Masamichi Sugimori, Ikuo Mitsui, Akio Ejima
Publikováno v:
Journal of Medicinal Chemistry. 41:2308-2318
Nineteen ring A- and F-modified hexacyclic analogues of camptothecin were synthesized by Friedländer condensation of appropriately substituted bicyclic amino ketones with tricyclic ketone and were evaluated for cytotoxicity and topoisomerase I inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0086e00c4f0cd440a5d654de0cee6be3
https://doi.org/10.1021/jm970765q
https://doi.org/10.1021/jm970765q
Autor:
Shuichi Ando, Tsunehiko Soga, Ikuo Mitsui, Hirofumi Terasawa, Kouichi Uoto, Haruhiro Takenoshita, Yasuhide Hirota, Toshiharu Yoshino
Publikováno v:
Chemical and Pharmaceutical Bulletin. 46:770-776
To develop non-prodrugs of taxoids with satisfactory stability in vivo, high water-solubility, and potent antitumor activity, we prepared several 10-O-sec-aminoethyl docetaxel analogs (3) and evaluated their cytotoxicity against mouse leukemia and hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b57cf8754b51c033a35a13f828c8b66
https://doi.org/10.1248/cpb.46.770
https://doi.org/10.1248/cpb.46.770