Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Kouichi Shiraishi"'
Publikováno v:
ACS Omega, Vol 9, Iss 32, Pp 34577-34588 (2024)
Externí odkaz:
https://doaj.org/article/fc8da255fd9d4ee6b07eeca778e3d8c8
Autor:
Kouichi Shiraishi, Masayuki Yokoyama
Publikováno v:
Science and Technology of Advanced Materials, Vol 20, Iss 1, Pp 324-336 (2019)
Polymeric-micelle carrier systems have emerged as a novel drug-carrier system and have been actively studied for anticancer drug targeting. In contrast, toxicological and immunological concerns related to not only polymeric-micelle carrier systems, b
Externí odkaz:
https://doaj.org/article/ca2d463ce8e042e48781c70208f5599e
Autor:
Kouki Fujioka, Sanshiro Hanada, Yuriko Inoue, Keisuke Sato, Kenji Hirakuri, Kouichi Shiraishi, Fumihide Kanaya, Keiichi Ikeda, Ritsuko Usui, Kenji Yamamoto, Seung U. Kim, Yoshinobu Manome
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 7, Pp 11742-11759 (2014)
Several in vivo studies suggest that nanoparticles (smaller than 100 nm) have the ability to reach the brain tissue. Moreover, some nanoparticles can penetrate into the brains of murine fetuses through the placenta by intravenous administration to pr
Externí odkaz:
https://doaj.org/article/6759a7e8d5294a10ba350e5f836a145e
Publikováno v:
Polymers, Vol 9, Iss 12, p 710 (2017)
We used photo irradiation to design core crosslinked polymeric micelles whose only significant physico-chemical change was in their physico-chemical stability, which helps elucidate poly(ethylene glycol) (PEG)-related immunogenicity. Synthetic routes
Externí odkaz:
https://doaj.org/article/acb64732dfe849878eddf73b85cbe3fa
Autor:
Kouichi Shiraishi, Masayuki Yokoyama
Publikováno v:
Magnetic Resonance Materials in Physics, Biology and Medicine. 33:527-536
We try to establish designs for the macromolecular agents possessing high Gd3+-chelating stability, because free Gd3+ ion released from Gd chelates is known as a risk factor to cause toxic side effects and a safety concern. We prepared three types of
Publikováno v:
Drug Delivery System. 34:213-215
Publikováno v:
Journal of Controlled Release. 253:165-171
Blood–brain barrier (BBB) opening is a key phenomenon for understanding ischemia-reperfusion injuries that are directly linked to hemorrhagic transformation. The recombinant human tissue-type plasminogen activator (rtPA) increases the risk of sympt
Autor:
Yusuke Inoue, Masanori Nojima, Osamu Abe, Shigeru Kiryu, Kuni Ohtomo, Masayuki Yokoyama, Koichiro Yasaka, Kouichi Shiraishi, Hiroyuki Akai
Publikováno v:
Journal of Magnetic Resonance Imaging. 47:238-245
PURPOSE To investigate the feasibility of polymeric micelle of poly(ethyleneglycol) (PEG)-b-poly(L-lysine-DOTA) (Gd-micelle) as a contrast agent for magnetic resonance lymphography (MRL). MATERIALS AND METHODS Twenty-four female BALB/c mice were rand
Autor:
Masako Shomura, Shunji Hirose, Kazuya Anzai, Yoshitaka Arase, Tatehiro Kagawa, Kota Tsuruya, Kouichi Shiraishi, Tetsuya Mine
Publikováno v:
Kanzo. 58:619-625
Autor:
Yusuke Sanada, Shinichi Mochizuki, Yoshie Maitani, Ken Ishii, Kouichi Shiraishi, Kumi Kawano, Masayuki Yokoyama, Kazuo Sakurai, Taiki Aoshi
Publikováno v:
Journal of Controlled Release. 234:59-67
Surface PEGylation on nanoparticles has greatly helped prolong their blood circulation half-lives. However, The injection of PEGylated nanoparticles into mice induced poly(ethylene glycol) (PEG)-specific IgM antibodies (anti-PEG IgMs), significantly