Výsledky vyhledávání - "Kouichi Kuwata"

Central role of vascular smooth muscle hyperreactivity in coronary hyperconstriction after balloon injury in miniature pigs

Autor: Toshiaki Kadokami, Kensuke Egashira, Yuichi Ohara, Takeshi Kuga, Akira Takeshita, Hiroaki Shimokawa, Hiroshi Hata, Kouichi Kuwata

Publikováno v: Coronary Artery Disease. 8:69-76

BACKGROUND Coronary constrictive responses to autacoids become augmented 1 week after balloon injury in our swine model. The present study aimed to elucidate the mechanisms of this effect. METHODS In 12 hypercholesterolaemic miniature pigs, the coron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643c0a35a94bb29a9f2fb88306fb3b75
https://doi.org/10.1097/00019501-199702000-00001

Zobrazit plný text záznamu

Altered Serotonin Receptor Subtypes Mediate Coronary Microvascular Hyperreactivityin Pigs With Chronic Inhibitionof Nitric Oxide Synthesis

Autor: Akira Takeshita, Kouichi Kuwata, Yoshihiro Fukumoto, Katsuo Sueishi, Takeshi Kuga, Hiroshi Yasutake, Kensuke Egashira, Hiroaki Shimokawa, Toshiaki Kadokami, Toshiyuki Kozai

Publikováno v: Circulation. 94:182-189

Background We previously reported that chronic inhibition of nitric oxide synthesis by administration of N ω -nitro- l -arginine methyl ester (L-NAME) causes microvascular hyperreactivity to 5-hydroxytryptamine (5-HT) and vascular structural changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40452c2612d47943998814917256761
https://doi.org/10.1161/01.cir.94.2.182

Zobrazit plný text záznamu

Simultaneous assessment of wall motion and coronary flow velocity in the left anterior descending coronary artery during dipyridamole stress echocardiography

Autor: Ken-ichi Arimura, Yuichi Nohtomi, Shoichi Kondo, Akira Yamada, Kenji Miyata, Shuichi Okamatsu, Kouichi Kuwata, Tohru Yamawaki, Masaaki Takeuchi, Kazushige Nagasawa

Publikováno v: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 16(5)

This study was designed to assess the feasibility and clinical meaning of simultaneous assessment of wall motion and coronary flow velocity (CFV) reserve in the left anterior descending coronary artery (LAD) by transthoracic approach for detecting LA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ae4c51e8f3f300f0cdb0dcc4fd4404
https://pubmed.ncbi.nlm.nih.gov/12724655

Zobrazit plný text záznamu

Increased expression of L-type calcium channels in vascular smooth muscle cells at spastic site in a porcine model of coronary artery spasm

Autor: Takeshi Kuga, Kouichi Kuwata, Akira Takeshita, Yoshihiro Fukumoto, Toshiyuki Kozai, Hiroaki Shimokawa, Yoshiaki Kadokami, Yukinori Arai, Kensuke Egashira, Yoji Hirakawa

Publikováno v: Journal of cardiovascular pharmacology. 35(5)

Coronary artery spasm is caused primarily by increased contractility of vascular smooth muscle. Excessive Ca2+ entry into vascular smooth muscle cells (VSMCs) may be one of the key mechanisms for the spasm, but no study has ever directly examined the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e90413b6ce9adb152eebc26840db6f
https://pubmed.ncbi.nlm.nih.gov/10813387

Zobrazit plný text záznamu

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

Autor: Kozo Kaibuchi, Akira Takeshita, Kouichi Kuwata, Kensuke Egashira, Naoki Katsumata, Toshiyuki Kozai, Minoru Seto, Hiroaki Shimokawa, Ichiro Ikegaki, Mutsuki Amano, Tadashi Kandabashi, T. Asano, Tohru Yamawaki

Publikováno v: Cardiovascular research. 43(4)

Objective: We recently demonstrated in our swine model of coronary artery spasm that enhanced myosin light chain (MLC) phosphorylations (both MLC mono- and diphosphorylations) play a central role in the pathogenesis of the spasm. However, the molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076d8397909c6671d855cb070387ffaf
https://pubmed.ncbi.nlm.nih.gov/10615430

Zobrazit plný text záznamu

Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta

Autor: Toshiyuki Kozai, Yasuharu Sasaki, T. Asano, Hiroaki Shimokawa, Ichiro Ikegaki, Kouichi Kuwata, Akira Takeshita, Naoki Katsumata, Tohru Yamawaki, Minoru Seto, Kensuke Egashira

Publikováno v: Circulation. 96(12)

Background Although coronary artery spasm plays an important role in a wide variety of ischemic heart diseases, the intracellular mechanism for the spasm remains to be clarified. We examined the role of myosin light chain (MLC) phosphorylations, a ke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4957f46445768f7452ba218e56dec248
https://pubmed.ncbi.nlm.nih.gov/9416877

Zobrazit plný text záznamu

Vasculoprotective role of inducible nitric oxide synthase at inflammatory coronary lesions induced by chronic treatment with interleukin-1beta in pigs in vivo

Autor: Toshiaki Kadokami, Yoshikazu Yonemitsu, Yoshihiro Fukumoto, Kouichi Kuwata, Kensuke Egashira, Katsuo Sueishi, Toshiyuki Kozai, Hiroaki Shimokawa, Takeshi Kuga, Akira Takeshita

Publikováno v: Circulation. 96(9)

Background We recently developed a porcine model in which chronic, local treatment with interleukin-1β (IL-1β) causes coronary arteriosclerotic changes and hyperconstrictive responses. Inflammatory cytokines are known to induce inducible NO synthas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00dd821a8dbab771b6a81c8f948cc3fe
https://pubmed.ncbi.nlm.nih.gov/9386181

Zobrazit plný text záznamu

Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo

Autor: Naoki Katsumata, Hiroaki Shimokawa, Kouichi Kuwata, Toshiaki Kadokami, Tohru Yamawaki, Akira Takeshita, Kensuke Egashira, Toshiyuki Kozai, Yoshihiro Fukumoto

Publikováno v: Coronary artery disease. 8(7)

Background Although platelet activating factor (PAF) is an important vasoactive substance released from activated leukocytes, platelets and endothelial cells, little is known about its effect at the inflammatory coronary lesions in vivo. Objective To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00657feaced4180ab22b0e70aeb1133a
https://pubmed.ncbi.nlm.nih.gov/9383603

Zobrazit plný text záznamu

Tyrosine kinase inhibitor markedly suppresses the development of coronary lesions induced by long-term treatment with platelet-derived growth factor in pigs in vivo

Autor: Kensuke Egashira, Sei Kobayashi, Kouichi Kuwata, Tadayoshi Shiraishi, Yoshihiro Fukumoto, Akira Takeshita, M. Koji Owada, Toshiyuki Kozai, Hideo Kanaide, Hiroaki Shimokawa, Akira Ito, Toshiaki Kadokami

Publikováno v: Journal of cardiovascular pharmacology. 29(4)

Platelet-derived growth factor (PDGF) plays an important role in the development of coronary atherosclerosis. However, it remains to be examined what morphologic and functional changes are induced in vivo by the long-term treatment with PDGF itself o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d58a77437fc8283cbaf3d68da49f4f5
https://pubmed.ncbi.nlm.nih.gov/9156365

Zobrazit plný text záznamu

Tyrosine kinase inhibitor suppresses the (re) stenotic changes of the coronary artery after balloon injury in pigs

Autor: Kensuke Egashira, Tadayoshi Shiraishi, Toshiaki Kadokami, Kouichi Kuwata, Hiroaki Shimokawa, Akira Takeshita, M. Koji Owada, Yoshihiro Fukumoto, Toshiyuki Kozai, Takeshi Kuga

Publikováno v: Cardiovascular research. 32(6)

Objective: Restenosis after percutaneous transluminal coronary angioplasty (PTCA) still remains a serious late complication. Many growth factors induced in restenotic lesions may be responsible for restenosis after PTCA. Most of the receptors for suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb359a24c8e189aa9dd3605f3bff398
https://pubmed.ncbi.nlm.nih.gov/9015416

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání