Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kouichi Kuwata"'
Autor:
Toshiaki Kadokami, Kensuke Egashira, Yuichi Ohara, Takeshi Kuga, Akira Takeshita, Hiroaki Shimokawa, Hiroshi Hata, Kouichi Kuwata
Publikováno v:
Coronary Artery Disease. 8:69-76
BACKGROUND Coronary constrictive responses to autacoids become augmented 1 week after balloon injury in our swine model. The present study aimed to elucidate the mechanisms of this effect. METHODS In 12 hypercholesterolaemic miniature pigs, the coron
Autor:
Akira Takeshita, Kouichi Kuwata, Yoshihiro Fukumoto, Katsuo Sueishi, Takeshi Kuga, Hiroshi Yasutake, Kensuke Egashira, Hiroaki Shimokawa, Toshiaki Kadokami, Toshiyuki Kozai
Publikováno v:
Circulation. 94:182-189
Background We previously reported that chronic inhibition of nitric oxide synthesis by administration of N ω -nitro- l -arginine methyl ester (L-NAME) causes microvascular hyperreactivity to 5-hydroxytryptamine (5-HT) and vascular structural changes
Autor:
Ken-ichi Arimura, Yuichi Nohtomi, Shoichi Kondo, Akira Yamada, Kenji Miyata, Shuichi Okamatsu, Kouichi Kuwata, Tohru Yamawaki, Masaaki Takeuchi, Kazushige Nagasawa
Publikováno v:
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 16(5)
This study was designed to assess the feasibility and clinical meaning of simultaneous assessment of wall motion and coronary flow velocity (CFV) reserve in the left anterior descending coronary artery (LAD) by transthoracic approach for detecting LA
Autor:
Takeshi Kuga, Kouichi Kuwata, Akira Takeshita, Yoshihiro Fukumoto, Toshiyuki Kozai, Hiroaki Shimokawa, Yoshiaki Kadokami, Yukinori Arai, Kensuke Egashira, Yoji Hirakawa
Publikováno v:
Journal of cardiovascular pharmacology. 35(5)
Coronary artery spasm is caused primarily by increased contractility of vascular smooth muscle. Excessive Ca2+ entry into vascular smooth muscle cells (VSMCs) may be one of the key mechanisms for the spasm, but no study has ever directly examined the
Autor:
Kozo Kaibuchi, Akira Takeshita, Kouichi Kuwata, Kensuke Egashira, Naoki Katsumata, Toshiyuki Kozai, Minoru Seto, Hiroaki Shimokawa, Ichiro Ikegaki, Mutsuki Amano, Tadashi Kandabashi, T. Asano, Tohru Yamawaki
Publikováno v:
Cardiovascular research. 43(4)
Objective: We recently demonstrated in our swine model of coronary artery spasm that enhanced myosin light chain (MLC) phosphorylations (both MLC mono- and diphosphorylations) play a central role in the pathogenesis of the spasm. However, the molecul
Autor:
Toshiyuki Kozai, Yasuharu Sasaki, T. Asano, Hiroaki Shimokawa, Ichiro Ikegaki, Kouichi Kuwata, Akira Takeshita, Naoki Katsumata, Tohru Yamawaki, Minoru Seto, Kensuke Egashira
Publikováno v:
Circulation. 96(12)
Background Although coronary artery spasm plays an important role in a wide variety of ischemic heart diseases, the intracellular mechanism for the spasm remains to be clarified. We examined the role of myosin light chain (MLC) phosphorylations, a ke
Autor:
Toshiaki Kadokami, Yoshikazu Yonemitsu, Yoshihiro Fukumoto, Kouichi Kuwata, Kensuke Egashira, Katsuo Sueishi, Toshiyuki Kozai, Hiroaki Shimokawa, Takeshi Kuga, Akira Takeshita
Publikováno v:
Circulation. 96(9)
Background We recently developed a porcine model in which chronic, local treatment with interleukin-1β (IL-1β) causes coronary arteriosclerotic changes and hyperconstrictive responses. Inflammatory cytokines are known to induce inducible NO synthas
Autor:
Naoki Katsumata, Hiroaki Shimokawa, Kouichi Kuwata, Toshiaki Kadokami, Tohru Yamawaki, Akira Takeshita, Kensuke Egashira, Toshiyuki Kozai, Yoshihiro Fukumoto
Publikováno v:
Coronary artery disease. 8(7)
Background Although platelet activating factor (PAF) is an important vasoactive substance released from activated leukocytes, platelets and endothelial cells, little is known about its effect at the inflammatory coronary lesions in vivo. Objective To
Autor:
Kensuke Egashira, Sei Kobayashi, Kouichi Kuwata, Tadayoshi Shiraishi, Yoshihiro Fukumoto, Akira Takeshita, M. Koji Owada, Toshiyuki Kozai, Hideo Kanaide, Hiroaki Shimokawa, Akira Ito, Toshiaki Kadokami
Publikováno v:
Journal of cardiovascular pharmacology. 29(4)
Platelet-derived growth factor (PDGF) plays an important role in the development of coronary atherosclerosis. However, it remains to be examined what morphologic and functional changes are induced in vivo by the long-term treatment with PDGF itself o
Autor:
Kensuke Egashira, Tadayoshi Shiraishi, Toshiaki Kadokami, Kouichi Kuwata, Hiroaki Shimokawa, Akira Takeshita, M. Koji Owada, Yoshihiro Fukumoto, Toshiyuki Kozai, Takeshi Kuga
Publikováno v:
Cardiovascular research. 32(6)
Objective: Restenosis after percutaneous transluminal coronary angioplasty (PTCA) still remains a serious late complication. Many growth factors induced in restenotic lesions may be responsible for restenosis after PTCA. Most of the receptors for suc