Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kouhei Matsui"'
Autor:
Miki Takemura, Keisuke Matsushima, Hideki Maki, Kouhei Matsui, Junko Kikuchi, Taichi Ueda, Yukiko Kan, Iori Kozono, Kazuyuki Minagawa
Publikováno v:
Journal of Medicinal Chemistry. 63:6090-6095
A novel lipopeptide antibiotic, stalobacin I (1), was discovered from a culture broth of an unidentified Gram-negative bacterium. Stalobacin I (1) had a unique chemical architecture composed of an upper and a lower half peptide sequence, which were l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d60b915e117a708081349a893a405d
https://doi.org/10.1021/acs.jmedchem.0c00295
https://doi.org/10.1021/acs.jmedchem.0c00295
Autor:
Akihiko Sato, Kouhei Matsui, Yoshito Numata, Haruka Maeda, Youhei Takagi, Yasuko Orba, Yutaka Yoshida, Kazunari Hattori, Hirofumi Sawa, Takeshi Kurosu, Haruaki Nobori, Kenichi Higashino
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3586-3590
NS2B-NS3 protease is an essential enzyme for the replication of dengue virus (DENV), which continues to be a serious threat to worldwide public health. We designed and synthesized a series of cyclic peptides mimicking the substrates of this enzyme, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456d655031c46510cbd27f8309a5eaac
https://doi.org/10.1016/j.bmcl.2017.05.027
https://doi.org/10.1016/j.bmcl.2017.05.027
Autor:
Katsumi Maenaka, Shunsuke Kita, Takanori Matsumaru, Kayoko Kanamitsu, Kouhei Matsui, Fumika Yakushiji, Satoshi Ichikawa, Satoshi Shuto, Hirotatsu Kojima, Yasuteru Shigeta, Takashi Tadokoro, Akira Matsuda, Eri Watanabe, Mayumi Ishii, Akira Katsuyama, Toshiaki Sunazuka, Hiroyuki Miyachi, Satoko Otsuguro, Tomoyasu Hirose, Tetsuo Nagano, Yukina Sato, Mizuki Watanabe, Masato Iwatsuki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 37:127847
To develop methodology to predict the potential druggability of middle molecules, we examined the structure, solubility, and permeability relationships of a diverse library (HKDL ver.1) consisting of 510 molecules (359 natural product derivatives, 76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43fed6e7d89fb0bd752f410503c0241
https://doi.org/10.1016/j.bmcl.2021.127847
https://doi.org/10.1016/j.bmcl.2021.127847
Publikováno v:
Chemistry - A European Journal. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f00d0b39f214598e70c2ab0a1a055248
https://doi.org/10.1002/chem.201785862
https://doi.org/10.1002/chem.201785862
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 23(58)
Peptidomimetics, non-natural mimicries of bioactive peptides, comprise an important class of drug molecules. The essence of the peptidomimetic design is to mimic the key conformation assumed by the bioactive peptides upon binding to their targets. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ab8b5913eb01f9d51545c92a29ac87
https://pubmed.ncbi.nlm.nih.gov/28632330
https://pubmed.ncbi.nlm.nih.gov/28632330
Publikováno v:
FEBS Letters. 544:223-227
A C36 linear acetylene alcohol, lembehyne A (LB-A), induces neuronal differentiation against neuroblastoma cells morphologically and also functionally. The differentiation and cytostatic effect induced by LB-A was specific to neuroblastoma, Neuro 2A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1a7aa466f122d69a3407156087b47f
https://doi.org/10.1016/s0014-5793(03)00506-4
https://doi.org/10.1016/s0014-5793(03)00506-4
Publikováno v:
Tetrahedron. 58:5417-5422
Two new long-chain acetylene alcohols named lembehynes B ( 2 ) and C ( 3 ) were isolated from an Indonesian marine sponge of Haliclona sp. Lembehynes B ( 2 ) and C ( 3 ), which have different types of long carbon-chain parts compared with that of lem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008fff08f65125e37f87209e830d968f
https://doi.org/10.1016/s0040-4020(02)00519-7
https://doi.org/10.1016/s0040-4020(02)00519-7
Publikováno v:
Engei Gakkai zasshi. 71:485-489
The cause of root browning (RB) in Lactuca sativa L. root, which often occurs in hydropoincs when a nutrient solution is prepared with tap water, was investigated. The induction of RB occurred only when plants were cultured in the solutions containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3d146c3d0d496e2573ccb4a6e8352ec
https://doi.org/10.2503/jjshs.71.485
https://doi.org/10.2503/jjshs.71.485
Publikováno v:
Chemistry - A European Journal. 23:2972-2972
The conformation of cyclic peptides is closely related to their physicochemical and biological properties, but their rational design to obtain a conformation with the desired properties is difficult. Here we present a new strategy using conformationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb13849c6eaf7ea951c1e65e82b2b9b
https://doi.org/10.1002/chem.201605972
https://doi.org/10.1002/chem.201605972
Autor:
Masanori Okano, Shin-ichi Akiyama, Kouhei Matsui, Takuya Itoh, Motomasa Kobayashi, Shunji Aoki, Rachmaniar Satari
Publikováno v:
Tetrahedron. 57:8951-8957
A novel briarane-type diterpene named brianthein A (1), which has been isolated from the gorgonian Briareum excavatum, reversed multidrug resistance (MDR) in human carcinoma cell lines, KB-C2, overexpressing P-glycoprotein (P-gp). The absolute stereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63809c9946ec98b139120828fa1d55c4
https://doi.org/10.1016/s0040-4020(01)00894-8
https://doi.org/10.1016/s0040-4020(01)00894-8