Výsledky vyhledávání - "Kou-Yi Tserng"

Dissociation between gene and protein expression of metabolic enzymes in a rodent model of heart failure

Autor: William C. Stanley, Eric E. Morgan, Brian D. Hoit, Martin E. Young, Margaret P. Chandler, Tracy A. McElfresh, Kou Yi Tserng, Theodore A. Kung, Julie H. Rennison

Publikováno v: European Journal of Heart Failure. 8:687-693

Studies in advanced heart failure show down-regulation of fatty acid oxidation genes, possibly due to decreased expression of the nuclear transcription factors peroxisome proliferator activated receptor alpha (PPARalpha) and retinoid X receptor alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb00ecf83720368efbbfc83c711ad43
https://doi.org/10.1016/j.ejheart.2006.01.005

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Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin

Autor: Martin E. Young, Julie H. Rennison, Hani N. Sabbah, William C. Stanley, Kou Yi Tserng, Tracy A. McElfresh, Isidore C. Okere, Brian D. Hoit, Paul Ernsberger, Margaret P. Chandler, Victor G. Sharov

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 291:H38-H44

Fatty acids are the primary fuel for the heart and are ligands for peroxisome proliferator-activated receptors (PPARs), which regulate the expression of genes encoding proteins involved in fatty acid metabolism. Saturated fatty acids, particularly pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f75c5318e07d9e9979a1f29e083c30
https://doi.org/10.1152/ajpheart.01295.2005

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A phase IB clinical and pharmacokinetic study of the angiogenesis inhibitor SU5416 and paclitaxel in recurrent or metastatic carcinoma of the head and neck

Autor: Matthew M. Cooney, Keith R. McCrae, R. Jeff McPeak, Afshin Dowlati, Pamela Ksenich, Vinit Makar, Pierre Lavertu, Kou Yi Tserng, Beth Overmoyer, Charles L. Hoppel, Percy Ivy, Scot C. Remick, Stephen T. Ingalls

Publikováno v: Cancer Chemotherapy and Pharmacology. 55:295-300

SU5416 is a novel small organic molecule that non-competitively inhibits the phosphorylation of the VEGF tyrosine kinase receptor, Flk-1. This phase IB study was performed to determine the safety, pharmacokinetics, and preliminary efficacy of the com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f196438188571b81cdb03c47ad22480
https://doi.org/10.1007/s00280-004-0871-5

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Pharmacokinetics of O6-Benzylguanine (NSC637037) and Its Metabolite, 8-Oxo-O6-Benzylguanine

Autor: Stephen T. Ingalls, Stanton Gerson, Timothy P. Spiro, Charles L. Hoppel, Xiaolin Li, Susan M. Majka, Kou Yi Tserng, James K. V. Willson, Erik M. Boczko

Publikováno v: The Journal of Clinical Pharmacology. 43:881-893

O 6 -Benzylguanine and its metabolite, 8-oxo-O 6 -benzylguanine, are equally potent inhibitors of the DNA repair enzyme, O 6 -alkylguanine-DNA alkyltransferase. Pharmacokinetic values are derived from cancer patients participating in a phase I trial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da83282dc27392377556dc37c67fcf2
https://doi.org/10.1177/0091270003256060

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Double bond in the side chain of 1α,25-dihydroxy-22-ene-vitamin D3 is reduced during its metabolism: studies in chronic myeloid leukemia (RWLeu-4) cells and rat kidney

Autor: Ronald L. Horst, Jeffrey W. Clark, Kou-Yi Tserng, D Balkundi, G. Satyanarayana Reddy, D.Sunita Rao, Milan R. Uskokovic

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 78:167-176

1alpha,25-Dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] is mainly metabolized via the C-24 oxidation pathway and undergoes several side chain modifications which include C-24 hydroxylation, C-24 ketonization, C-23 hydroxylation and side chain cleavage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2da00447ec11cf2fa41bd1a2b4147b3
https://doi.org/10.1016/s0960-0760(01)00082-6

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Isolation and identification of 1α-hydroxy-24-oxovitamin D 3 and 1α,23-dihydroxy-24-oxovitamin D 3

Autor: Mei-Ling Siu-Caldera, Kou-Yi Tserng, G. Satyanarayana Reddy, D.Sunita Rao, Seiichi Ishizuka, Edward A. Weinstein, Milan R. Uskokovic

Publikováno v: Biochemical Pharmacology. 58:1965-1973

1alpha,24(R)-Dihydroxyvitamin D3 [1alpha,24(R)(OH)2D3], a synthetic vitamin D3 analog, has been developed as a drug for topical use in the treatment of psoriasis. At present, the target tissue metabolism of 1alpha,24(R)(OH)2D3 is not understood compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9454c77a956227d216bc0ad6a756b3e
https://doi.org/10.1016/s0006-2952(99)00293-2

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Isolation and identification of 4,25-dihydroxyvitamin D2: a novel A-ring hydroxylated metabolite of vitamin D2

Autor: Kou-Yi Tserng, Mei-Ling Siu-Caldera, Milan R. Uskokovic, G. Satyanarayana Reddy, Ronald L. Horst, Ramesh Dayal, D.Sunita Rao

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 71:63-70

Vitamin D 2 is less toxic in rats when compared to vitamin D 3 . Our laboratory has been involved in research projects which were directed towards identifying the possible mechanisms responsible for the toxicity differences between vitamins D 2 and D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed5ed11808d960d18df771e07d4d818
https://doi.org/10.1016/s0960-0760(99)00125-9

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Contributions of liver and kidneys to glycerol production and utilization in the dog

Autor: Jeffrey W. Hazey, D. W. Kirschenbaum, J. Koshy, Kou-Yi Tserng, M. V. Soloviev, D. Lucas, Henri Brunengraber, Stephen F. Previs, A. P. Keating, S. K. Martin, F. David

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 271:E1118-E1124

The classical concept holds that liver and kidneys are the main sinks of glycerol released by adipose tissue. However, rates of glycerol appearance (Ra) exceed the rate of glycerol delivery to liver and kidneys. We measured the hepatic and renal cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525c5218337fc6fee7eac7bb38d5e891
https://doi.org/10.1152/ajpendo.1996.271.6.e1118

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Reduction pathway of cis-5 unsaturated fatty acids in intact rat-liver and rat-heart mitochondria: assessment with stable-isotype-labelled substrates

Autor: Lin-Su Chen, Kou-Yi Tserng, Shiow-Jen Jin

Publikováno v: Biochemical Journal. 313:581-588

Besides the conventional isomerase-mediated pathway, unsaturated fatty acids with odd-numbered double bonds are also metabolized by reduction pathways with NADPH as cofactor. The relative contributions of these pathways were measured in intact rat-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099e445d3af0bc8f78fcbe0f89453cc7
https://doi.org/10.1042/bj3130581

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Purification and Mechanism of .DELTA.3,.DELTA.5-t-2,t-4-Dienoyl-CoA Isomerase from Rat Liver

Autor: Kou-Yi Tserng, Lin-Su Chen, Shiow-Jen Jin

Publikováno v: Biochemistry. 33:10527-10534

A new enzyme, i.e., delta 3,delta 5-t-2,t-4-dienoyl-CoA isomerase, required in the NADPH-dependent metabolic pathway of odd-numbered double bond, unsaturated fatty acids, was isolated and purified to apparent homogeneity from rat liver. In the oxidat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77dd9dbc4ba4f16fa29c43efcaabc01
https://doi.org/10.1021/bi00200a039

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