VCP Inhibition Augments NLRP3 Inflammasome Activation.

Autor: Sharma A; Department of Neurology, Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA., Dhavale DD; Department of Neurology, Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA., Kotzbauer PT; Department of Neurology, Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA., Weihl CC; Department of Neurology, Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA. weihlc@wustl.edu.

Publikováno v: Inflammation [Inflammation] 2024 Oct; Vol. 47 (5), pp. 1868-1883. Date of Electronic Publication: 2024 Apr 02.

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.

Autor: Dhavale DD; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Barclay AM; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Borcik CG; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA., Basore K; Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO, 63110, USA., Berthold DA; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Gordon IR; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Liu J; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Milchberg MH; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA., O'Shea JY; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Rau MJ; Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO, 63110, USA., Smith Z; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Sen S; Theoretical and Computational Biophysics Group, NIH Resource for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Summers B; Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO, 63110, USA., Smith J; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Warmuth OA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA., Perrin RJ; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Perlmutter JS; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Radiology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine, St. Louis, MO, 63110, USA., Chen Q; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Fitzpatrick JAJ; Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO, 63110, USA., Schwieters CD; Computational Biomolecular Magnetic Resonance Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Tajkhorshid E; Theoretical and Computational Biophysics Group, NIH Resource for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Rienstra CM; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. crienstra@wisc.edu.; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA. crienstra@wisc.edu.; Morgridge Institute for Research, University of Wisconsin-Madison, Madison, WI, 53706, USA. crienstra@wisc.edu.; National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, 53706, USA. crienstra@wisc.edu., Kotzbauer PT; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA. kotzbauerp@wustl.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Mar 29; Vol. 15 (1), pp. 2750. Date of Electronic Publication: 2024 Mar 29.

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy.

Autor: Kim HY; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Chia WK; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Hsieh CJ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Saturnino Guarino D; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Graham TJA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Lengyel-Zhand Z; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Schneider M; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Tomita C; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Lougee MG; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States., Kim HJ; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6303, United States., Pagar VV; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States., Lee H; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Hou C; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Garcia BA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6303, United States., Petersson EJ; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States., O'Shea J; Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110-1010, United States., Kotzbauer PT; Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110-1010, United States., Mathis CA; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States., Lee VM; Center for Neurodegenerative Disease Research, Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-2676, United States., Luk KC; Center for Neurodegenerative Disease Research, Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-2676, United States., Mach RH; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Sep 14; Vol. 66 (17), pp. 12185-12202. Date of Electronic Publication: 2023 Aug 31.

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.

Autor: Dhavale DD; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA., Barclay AM; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Borcik CG; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA., Basore K; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA., Gordon IR; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA., Liu J; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA., Milchberg MH; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA., O'shea J; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA., Rau MJ; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA., Smith Z; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA., Sen S; Theoretical and Computational Biophysics Group, NIH Resource for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Summers B; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA., Smith J; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, IL 61801, USA., Warmuth OA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA., Chen Q; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, IL 61801, USA., Fitzpatrick JAJ; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA., Schwieters CD; Computational Biomolecular Magnetic Resonance Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Tajkhorshid E; Theoretical and Computational Biophysics Group, NIH Resource for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Rienstra CM; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.; Morgridge Institute for Research, University of Wisconsin-Madison, Madison, WI 53706 USA.; National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI 53706, USA., Kotzbauer PT; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 10. Date of Electronic Publication: 2023 Jan 10.

Proteinopathy and Longitudinal Cognitive Decline in Parkinson Disease.

Autor: Myers PS; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO., O'Donnell JL; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO., Jackson JJ; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO., Lessov-Schlaggar CN; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO., Miller RL; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO., Foster ER; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO., Cruchaga C; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO., Benitez BA; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO., Kotzbauer PT; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO., Perlmutter JS; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO., Campbell MC; From the Department of Neurology (P.S.M., J.L.O., R.L.M., E.R.F., C.C., P.T.K., J.S.P., M.C.C.), Department of Psychiatry (C.N.L.-S., E.R.F., C.C., B.A.B.), Program in Occupational Therapy (E.R.F., J.S.P.), Department of Genetics (C.C.), Department of Radiology (J.S.P., M.C.C.), Department of Neuroscience (J.S.P.), and Program in Physical Therapy (J.S.P.), Washington University School of Medicine; and Department of Psychological and Brain Sciences (J.J.J.), Washington University in St. Louis, MO. meghanc@wustl.edu.

Publikováno v: Neurology [Neurology] 2022 Jul 05; Vol. 99 (1), pp. e66-e76. Date of Electronic Publication: 2022 Apr 13.