BTG1 mutation yields supercompetitive B cells primed for malignant transformation.

Autor: Mlynarczyk C; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Teater M; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Pae J; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA., Chin CR; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Tri-Institutional PhD Program in Computational Biomedicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Wang L; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Arulraj T; Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology (BRICS), Helmholtz Centre for Infection Research, Braunschweig, Germany., Barisic D; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Papin A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Hoehn KB; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Kots E; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Ersching J; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA., Bandyopadhyay A; Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology (BRICS), Helmholtz Centre for Infection Research, Braunschweig, Germany., Barin E; Department of Pharmacology and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Poh HX; Department of Pharmacology and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Evans CM; Molecular Pharmacology Program and Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Chadburn A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Chen Z; Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA., Shen H; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Isles HM; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Pelzer B; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Tsialta I; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Doane AS; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Geng H; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Rehman MH; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Medicine-Qatar, Doha, Qatar., Melnick J; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Morgan W; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Nguyen DTT; Molecular Pharmacology Program and Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Elemento O; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine and Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Kharas MG; Molecular Pharmacology Program and Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jaffrey SR; Department of Pharmacology and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Scott DW; Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada., Khelashvili G; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Meyer-Hermann M; Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology (BRICS), Helmholtz Centre for Infection Research, Braunschweig, Germany.; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany., Victora GD; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA., Melnick A; Division of Hematology and Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2023 Jan 20; Vol. 379 (6629), pp. eabj7412. Date of Electronic Publication: 2023 Jan 20.

Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants.

Autor: Kots E; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York., Mlynarczyk C; Division of Hematology/Oncology, Department of Medicine, Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Melnick A; Division of Hematology/Oncology, Department of Medicine, Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Khelashvili G; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York. Electronic address: gek2009@med.cornell.edu.

Publikováno v: Biophysical journal [Biophys J] 2022 Oct 04; Vol. 121 (19), pp. 3753-3764. Date of Electronic Publication: 2022 Apr 21.

Molecular determinants of pH sensing in the proton-activated chloride channel.

Autor: Osei-Owusu J; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Kots E; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065., Ruan Z; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503., Mihaljević L; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Chen KH; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Tamhaney A; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Ye X; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503., Lü W; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503., Weinstein H; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065., Qiu Z; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Aug 02; Vol. 119 (31), pp. e2200727119. Date of Electronic Publication: 2022 Jul 25.

Simulation of pH-Dependent Conformational Transitions in Membrane Proteins: The CLC-ec1 Cl ^- /H ⁺ Antiporter.

Autor: Kots E; Department of Physiology and Biophysics, Weill Cornell Medical School, New York, NY 10065, USA., Shore DM; Department of Physiology and Biophysics, Weill Cornell Medical School, New York, NY 10065, USA., Weinstein H; Department of Physiology and Biophysics, Weill Cornell Medical School, New York, NY 10065, USA.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Nov 18; Vol. 26 (22). Date of Electronic Publication: 2021 Nov 18.

Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: Mechanism and possible advantages for myasthenia gravis treatment

Autor: Kharlamova A., Lushchekina S., Petrov K., Kots E., Nachon F., Villard-Wandhammer M., Zueva I., Krejci E., Reznik V., Zobov V., Nikolsky E., Masson P.

Publikováno v: SCOPUS02646021-2016-473-9-SID84975318599

© 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug

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https://openrepository.ru/article?id=211874