Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress

Autor: Michelle Harreman Lehner, Jane Walker, Kotryna Temcinaite, Anna Herlihy, Michael Taschner, Adam C. Berger, Anita H. Corbett, A. Barbara Dirac Svejstrup, Jesper Q. Svejstrup

Publikováno v: Lehner, M H, Walker, J, Temcinaite, K, Herlihy, A, Taschner, M, Berger, A C, Corbett, A H, Dirac Svejstrup, A B & Svejstrup, J Q 2022, ' Yeast Smy2 and its human homologs GIGYF1 and-2 regulate Cdc48/VCP function during transcription stress ', Cell Reports, vol. 41, no. 4, 111536 . https://doi.org/10.1016/j.celrep.2022.111536

The “last resort” pathway results in ubiquitylation and degradation of RNA polymerase II in response to transcription stress and is governed by factors such as Def1 in yeast. Here, we show that the SMY2 gene acts as a multi-copy suppressor of DEF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91c5fb4fb55d124db239212a9c8e19d
https://pubmed.ncbi.nlm.nih.gov/36288698