Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis.

Autor: Nakatsuji T; Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA., Chen TH; Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA., Narala S; Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA., Chun KA; Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA., Two AM; Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA., Yun T; Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA., Shafiq F; Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA., Kotol PF; Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA., Bouslimani A; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92092, USA., Melnik AV; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92092, USA., Latif H; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92092, USA., Kim JN; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92092, USA., Lockhart A; Rho Federal Systems Division Inc., Chapel Hill, NC 27517, USA., Artis K; Rho Federal Systems Division Inc., Chapel Hill, NC 27517, USA., David G; Rho Federal Systems Division Inc., Chapel Hill, NC 27517, USA., Taylor P; Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA., Streib J; Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA., Dorrestein PC; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92092, USA.; Departments of Chemistry, Biochemistry and Pharmacology, University of California, San Diego, La Jolla, CA 92092, USA., Grier A; Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14611, USA., Gill SR; Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14611, USA., Zengler K; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92092, USA., Hata TR; Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA., Leung DY; Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA., Gallo RL; Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA. rgallo@ucsd.edu.

Publikováno v: Science translational medicine [Sci Transl Med] 2017 Feb 22; Vol. 9 (378).

Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor.

Autor: Two AM; Division of Dermatology, University of California San Diego, San Diego, California, USA., Hata TR; Division of Dermatology, University of California San Diego, San Diego, California, USA., Nakatsuji T; Division of Dermatology, University of California San Diego, San Diego, California, USA., Coda AB; Division of Dermatology, University of California San Diego, San Diego, California, USA., Kotol PF; Division of Dermatology, University of California San Diego, San Diego, California, USA., Wu W; Division of Dermatology, University of California San Diego, San Diego, California, USA., Shafiq F; Division of Dermatology, University of California San Diego, San Diego, California, USA., Huang EY; Division of Dermatology, University of California San Diego, San Diego, California, USA; Therapeutics Clinical Research, San Diego, California, USA; Skin EpiBiotics Inc., San Diego, California, USA., Gallo RL; Division of Dermatology, University of California San Diego, San Diego, California, USA; Skin EpiBiotics Inc., San Diego, California, USA. Electronic address: rgallo@ucsd.edu.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2014 Apr; Vol. 134 (4), pp. 1143-1145. Date of Electronic Publication: 2013 Nov 08.

Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands.

Autor: Morizane S; Division of Dermatology, Department of Medicine, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA. zanemori@cc.okayama-u.ac.jp, Yamasaki K, Mühleisen B, Kotol PF, Murakami M, Aoyama Y, Iwatsuki K, Hata T, Gallo RL

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2012 Jan; Vol. 132 (1), pp. 135-43. Date of Electronic Publication: 2011 Aug 18.