Low-burden TP53 mutations represent frequent genetic events in CLL with an increased risk for treatment initiation.

Autor: László T; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Kotmayer L; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Fésüs V; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.; Kaposi Mór University Teaching Hospital of County Somogy, Kaposvár, Hungary., Hegyi L; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Gróf S; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Nagy Á; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Kajtár B; Department of Pathology, University of Pécs Medical School, Pécs, Hungary., Balogh A; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Weisinger J; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Masszi T; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Nagy Z; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Farkas P; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Demeter J; Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary., Istenes I; Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary., Szász R; Division of Hematology, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary., Gergely L; Division of Hematology, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary., Sulák A; 2nd Department of Internal Medicine and Cardiology Center, University of Szeged, Szeged, Hungary., Borbényi Z; 2nd Department of Internal Medicine and Cardiology Center, University of Szeged, Szeged, Hungary., Lévai D; Hematology and Lymphoma Unit, National Institute of Oncology, Budapest, Hungary., Schneider T; Hematology and Lymphoma Unit, National Institute of Oncology, Budapest, Hungary., Pettendi P; Hetényi Géza Hospital and Clinic of County Jász-Nagykun-Szolnok, Szolnok, Hungary., Bodai E; Hetényi Géza Hospital and Clinic of County Jász-Nagykun-Szolnok, Szolnok, Hungary., Szerafin L; Hospitals of County Szabolcs-Szatmár-Bereg and University Teaching Hospital, Nyíregyháza, Hungary., Rejtő L; Hospitals of County Szabolcs-Szatmár-Bereg and University Teaching Hospital, Nyíregyháza, Hungary., Bátai Á; Fejér County Szent György University Teaching Hospital, Székesfehérvár, Hungary., Dömötör MÁ; Fejér County Szent György University Teaching Hospital, Székesfehérvár, Hungary., Sánta H; Fejér County Szent György University Teaching Hospital, Székesfehérvár, Hungary., Plander M; Markusovszky University Teaching Hospital, Szombathely, Hungary., Szendrei T; Markusovszky University Teaching Hospital, Szombathely, Hungary., Hamed A; Petz Aladár University Teaching Hospital, Győr, Hungary., Lázár Z; Petz Aladár University Teaching Hospital, Győr, Hungary., Pauker Z; Borsod-Abaúj-Zemplén County Hospital and University Teaching Hospital, Miskolc, Hungary., Radványi G; Borsod-Abaúj-Zemplén County Hospital and University Teaching Hospital, Miskolc, Hungary., Kiss A; Military Hospital - State Health Centre, Budapest, Hungary., Körösmezey G; Military Hospital - State Health Centre, Budapest, Hungary., Jakucs J; Békés County Central Hospital, Békéscsaba, Hungary., Dombi PJ; St. Borbála Hospital, Tatabánya, Hungary., Simon Z; St. Borbála Hospital, Tatabánya, Hungary., Klucsik Z; Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary., Gurzó M; Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary., Tiboly M; Hospital of Keszthely, Keszthely, Hungary., Vidra T; Soproni Erzsébet Teaching Hospital and Rehabilitation Institute, Sopron, Hungary., Ilonczai P; Markhot Ferenc Teaching Hospital, Eger, Hungary., Bors A; Central Hospital of Southern Pest - National Institute of Hematology and Infectology, Budapest, Hungary., Andrikovics H; Central Hospital of Southern Pest - National Institute of Hematology and Infectology, Budapest, Hungary., Egyed M; Kaposi Mór University Teaching Hospital of County Somogy, Kaposvár, Hungary., Székely T; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Masszi A; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary.; Hematology and Lymphoma Unit, National Institute of Oncology, Budapest, Hungary., Alpár D; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Matolcsy A; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.; Department of Laboratory Medicine, Karolinska Institute, Solna, Sweden., Bödör C; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.

Publikováno v: The journal of pathology. Clinical research [J Pathol Clin Res] 2024 Jan; Vol. 10 (1), pp. e351. Date of Electronic Publication: 2023 Nov 21.

Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency.

Autor: Marin-Bejar O; Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL) and Program for Clinical Translation of Regenerative Medicine in Catalonia (P-CMRC), Barcelona. omarin@idibell.cat., Romero-Moya D; Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL) and Program for Clinical Translation of Regenerative Medicine in Catalonia (P-CMRC), Barcelona., Rodriguez-Ubreva J; Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), Barcelona., Distefano M; Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona., Lessi F; Fondazione Pisana Per la Scienza ONLUS (FPS), San Giuliano Terme., Aretini P; Fondazione Pisana Per la Scienza ONLUS (FPS), San Giuliano Terme., Liquori A; Hematology Research Group, Instituto de Investigación Sanitaria La Fe, Valencia, Spain; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid., Castaño J; Advanced and Cell Therapy Services. Banc de Sang i Teixits, Barcelona., Kozyra E; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine; Faculty of Biology, University of Freiburg, Freiburg., Kotmayer L; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University. Budapest, Hungary., Bueno C; Josep Carreras Leukaemia Research Institute. Department of Biomedicine. School of Medicine, University of Barcelona, Barcelona., Cervera J; Hematology Research Group, Instituto de Investigación Sanitaria La Fe, Valencia, Spain; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain; Genetics Unit, Hospital Universitario y Politécnico La Fe, Valencia., Rodriguez-Gallego JC; Department of Immunology, University Hospital of Gran Canaria Dr. Negrin, Canarian Health System, Las Palmas de Gran Canaria, Spain; Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain; Department of Medical and Surgical Sciences, School of Medicine, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria., Nomdedeu JF; Servei d'Hematologia Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, IIB Sant Pau/Josep Carreras Leukaemia Research Institute (IJC), Barcelona., Murillo-Sanjuán L; Pediatric Hematology and Oncology Division, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Barcelona., De Heredia CD; Pediatric Hematology and Oncology Division, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Barcelona., Pérez-Martinez A; Pediatric Department, Universidad Autonoma de Madrid, Madrid, Spain; Hospital La Paz Institute for Health Research, Madrid, Spain; Pediatric Hemato-Oncology Department, University Hospital La Paz, Madrid., López-Cadenas F; Servicio de Hematología Hospital Clínico Universitario de Salamanca, salamanca, Spain; Instituto Biosanitario de Salamanca (IBSAL). Salamanca., Martínez-Laperche C; Servicio de Hematología, Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid., Dorado-Herrero N; Servicio de Hematología, Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid., Marco FM; Immunology Department, Dr. Balmis General University Hospital; Institute for Health and Biomedical Research (ISABIAL), Alicante., Prósper F; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain; Area de Hemato-Oncología, CIMA Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IDISNA), Pamplona, Spain; Servicio de Hematologia, CCUN, Clínica Universidad de Navarra, Universidad de Navarra, Pamplona., Menendez P; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain; Josep Carreras Leukaemia Research Institute. Department of Biomedicine. School of Medicine, University of Barcelona, Barcelona, Spain; Red Española de Terapias Avanzadas (TERAV) - Instituto de Salud Carlos III, Madrid, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona., Valcárcel D; Servei d'Hematologia, Vall d'Hebron Hospital Universitari; Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO); Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona., Ballestar E; Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), Barcelona, Spain; Epigenetics in Inflammatory and Metabolic Diseases Laboratory, Health Science Center (HSC), East China Normal University (ECNU), Shanghai., Bödör C; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University. Budapest, Hungary., Bigas A; Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain; Programa de Investigación en Cáncer, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Josep Carreras Leukaemia Research Institute (IJC), Barcelona., Catalá A; Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid., Wlodarski MW; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN., Giorgetti A; Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL) and Program for Clinical Translation of Regenerative Medicine in Catalonia (P-CMRC), Barcelona, Spain; Fondazione Pisana Per la Scienza ONLUS (FPS), San Giuliano Terme, Italy; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Barcelona University, Barcelona. agiorgetti@idibell.cat.

Publikováno v: Haematologica [Haematologica] 2023 Sep 01; Vol. 108 (9), pp. 2551-2557. Date of Electronic Publication: 2023 Sep 01.

Landscape of BCL2 Resistance Mutations in a Real-World Cohort of Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Treated with Venetoclax.

Autor: Kotmayer L; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary., László T; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary., Mikala G; South-Pest Central Hospital, National Institute of Hematology and Infectology, 1097 Budapest, Hungary., Kiss R; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary., Lévay L; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary., Hegyi LL; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary., Gróf S; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary., Nagy T; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary.; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary., Barna G; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary., Farkas P; Department of Internal Medicine and Hematology, Semmelweis University, 1085 Budapest, Hungary., Weisinger J; Department of Internal Medicine and Hematology, Semmelweis University, 1085 Budapest, Hungary., Nagy Z; Department of Internal Medicine and Hematology, Semmelweis University, 1085 Budapest, Hungary., Balogh A; Department of Internal Medicine and Hematology, Semmelweis University, 1085 Budapest, Hungary., Masszi T; Department of Internal Medicine and Hematology, Semmelweis University, 1085 Budapest, Hungary., Demeter J; Department of Internal Medicine and Oncology, Semmelweis University, 1085 Budapest, Hungary., Sulák A; 2nd Department of Internal Medicine and Cardiology Center, University of Szeged, 6725 Szeged, Hungary., Kohl Z; 1st Department of Internal Medicine, Clinical Centre, University of Pécs, 7622 Pécs, Hungary., Alizadeh H; 1st Department of Internal Medicine, Clinical Centre, University of Pécs, 7622 Pécs, Hungary., Egyed M; Kaposi Mór University Teaching Hospital of County Somogy, 7400 Kaposvár, Hungary., Pettendi P; Hetényi Géza Hospital, Clinic of County Jász-Nagykun-Szolnok, 5000 Szolnok, Hungary., Gergely L; Division of Hematology, Department of Internal Medicine, University of Debrecen, 4032 Debrecen, Hungary., Plander M; Markusovszky University Teaching Hospital, 9700 Szombathely, Hungary., Pauker Z; Borsod-Abaúj-Zemplén County Hospital and University Teaching Hospital, 3515 Miskolc, Hungary., Masszi A; National Institute of Oncology, 1122 Budapest, Hungary., Matolcsy A; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary.; Department of Laboratory Medicine, Karolinska Institute, 171 77 Solna, Sweden., Szász R; Division of Hematology, Department of Internal Medicine, University of Debrecen, 4032 Debrecen, Hungary., Bödör C; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary., Alpár D; HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 18; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 18.

141P Comprehensive genomic profiling-based precision oncology in the management of rare paediatric soft tissue sarcomas

Autor: Cervi, C., Bedics, G., Brzon, O., Kotmayer, L., Sápi, Z., Zajta, E., Hegyi, L., Pápay, J., Dezső, K., Varga, E., Felkai, L., Bánusz, R., Bödör, C., Csóka, M.

Publikováno v: In Annals of Oncology October 2022 33 Supplement 8:S1427-S1427

Revealing a Phenotypical Appearance of Ibrutinib Resistance in Patients With Chronic Lymphocytic Leukaemia by Flow Cytometry.

Autor: Takács F; Department of Pathology and Experimental Cancer Research, HCEMM-SE Molecular Oncohematology Research Group, Semmelweis University, Budapest, Hungary.; Center for Pathology, University Medical Center-University of Freiburg, Freiburg, Germany., Kotmayer L; Department of Pathology and Experimental Cancer Research, HCEMM-SE Molecular Oncohematology Research Group, Semmelweis University, Budapest, Hungary., Czeti Á; Department of Pathology and Experimental Cancer Research, HCEMM-SE Molecular Oncohematology Research Group, Semmelweis University, Budapest, Hungary., Szalóki G; Department of Pathology and Experimental Cancer Research, HCEMM-SE Molecular Oncohematology Research Group, Semmelweis University, Budapest, Hungary., László T; Department of Pathology and Experimental Cancer Research, HCEMM-SE Molecular Oncohematology Research Group, Semmelweis University, Budapest, Hungary., Mikala G; South-Pest Central Hospital-National Institute for Hematology and Infectious Diseases, Budapest, Hungary., Márk Á; Department of Pathology and Experimental Cancer Research, HCEMM-SE Molecular Oncohematology Research Group, Semmelweis University, Budapest, Hungary., Masszi A; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Farkas P; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Plander M; Department of Hematology, Markusovszky University Teaching Hospital, Szombathely, Hungary., Weisinger J; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Demeter J; Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary., Fekete S; South-Pest Central Hospital-National Institute for Hematology and Infectious Diseases, Budapest, Hungary., Szerafin L; Hospitals of Szabolcs-Szatmár-Bereg County and University Teaching Hospital, Nyíregyháza, Hungary., Deák BM; National Institute of Oncology, Budapest, Hungary., Szaleczky E; National Institute of Oncology, Budapest, Hungary., Sulák A; 2nd Department of Internal Medicine and Cardiology Center, University of Szeged, Szeged, Hungary., Borbényi Z; 2nd Department of Internal Medicine and Cardiology Center, University of Szeged, Szeged, Hungary., Barna G; Department of Pathology and Experimental Cancer Research, HCEMM-SE Molecular Oncohematology Research Group, Semmelweis University, Budapest, Hungary.

Publikováno v: Pathology oncology research : POR [Pathol Oncol Res] 2022 Sep 21; Vol. 28, pp. 1610659. Date of Electronic Publication: 2022 Sep 21 (Print Publication: 2022).