Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Kothandaraman Narasimhan"'
Autor:
Li Chen, Sartaj Ahmad Mir, Anne K. Bendt, Esther W. L. Chua, Kothandaraman Narasimhan, Karen Mei-Ling Tan, See Ling Loy, Kok Hian Tan, Lynette P. Shek, Jerry Chan, Fabian Yap, Michael J. Meaney, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Neerja Karnani, Markus R. Wenk
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-24 (2023)
Abstract Background Adaptations in lipid metabolism are essential to meet the physiological demands of pregnancy and any aberration may result in adverse outcomes for both mother and offspring. However, there is a lack of population-level studies to
Externí odkaz:
https://doaj.org/article/679f327d8a4d4d44a9bb74f4acdd4ab7
Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles
Autor:
Gerard Wong, Kothandaraman Narasimhan, Wei Fun Cheong, Sharon Ng, Izzuddin M. Aris, See Ling Loy, Anne K. Bendt, Kok Hian Tan, Fabian K. P. Yap, Lynette P. Shek, Yap Seng Chong, Peter D. Gluckman, Keith M. Godfrey, Yung Seng Lee, Markus R. Wenk, Neerja Karnani, Shiao-Yng Chan
Publikováno v:
Nutrients, Vol 16, Iss 2, p 274 (2024)
Dysregulated transplacental lipid transfer and fetal–placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated wi
Externí odkaz:
https://doaj.org/article/b47fa868d8ce4d6da4429b55f67d6d72
Autor:
Sartaj Ahmad Mir, Li Chen, Satvika Burugupalli, Bo Burla, Shanshan Ji, Adam Alexander T. Smith, Kothandaraman Narasimhan, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Kevin Huynh, Corey Giles, Ding Mei, Gerard Wong, Fabian Yap, Kok Hian Tan, Fiona Collier, Richard Saffery, Peter Vuillermin, Anne K. Bendt, David Burgner, Anne-Louise Ponsonby, Yung Seng Lee, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Peter J. Meikle, Markus R. Wenk, Neerja Karnani
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Lipids play a vital role in health and disease, but changes to their circulating levels and the link with obesity remain poorly characterized in expecting mothers and their offspring in early childhood. Methods LC-MS/MS-based quan
Externí odkaz:
https://doaj.org/article/2a524f4cbd2448029ad0b8261c9144bb
Autor:
Sartaj Ahmad Mir, Soon Boon Justin Wong, Kothandaraman Narasimhan, Chua W. L. Esther, Shanshan Ji, Bo Burla, Markus R. Wenk, David S. P. Tan, Anne K. Bendt
Publikováno v:
Metabolites, Vol 11, Iss 9, p 597 (2021)
Cancer metabolism is associated with the enhanced lipogenesis required for rapid growth and proliferation. However, the magnitude of dysregulation of diverse lipid species still requires significant characterization, particularly in ovarian clear cel
Externí odkaz:
https://doaj.org/article/8ff74ac5a20749a59bae808a0928aeba
Joint modelling of association networks and longitudinal biomarkers: an application to child obesity
Autor:
Cremaschi, Andrea, De Iorio, Maria, Kothandaraman, Narasimhan, Yap, Fabian, Tint, Mya Tway, Eriksson, Johan
The prevalence of chronic non-communicable diseases such as obesity has noticeably increased in the last decade. The study of these diseases in early life is of paramount importance in determining their course in adult life and in supporting clinical
Externí odkaz:
http://arxiv.org/abs/2111.06212
Autor:
Razvi Khalil, Keow Peh B, Huak Chan Y, Brendan Pang NK, Bajic Vladimir B, Kothandaraman Narasimhan, Salto-Tellez Manuel, Choolani Mahesh
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 64 (2010)
Abstract Background Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer are largely unknown.
Externí odkaz:
https://doaj.org/article/880bb2abed9e4d9b8c663d4f4861c61d
Akademický článek
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Autor:
Hong Pan, Pei Fang Tan, Ives Y Lim, Jason Huan, Ai Ling Teh, Li Chen, Min Gong, Felicia Tin, Sartaj Ahmad Mir, Kothandaraman Narasimhan, Jerry K Y Chan, Kok Hian Tan, Michael S Kobor, Peter J Meikle, Markus R Wenk, Yap Seng Chong, Johan G Eriksson, Peter D Gluckman, Neerja Karnani
Asians are underrepresented across many omics databases, thereby limiting the potential of precision medicine in nearly 60% of the global population. As such, there is a pressing need for multi-omics derived quantitative trait loci (QTLs) to fill the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab39b0dd9f22777fe70b382a51284554
http://hdl.handle.net/10138/348348
http://hdl.handle.net/10138/348348
Umbilical cord plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles
Autor:
Gerard Wong, Kothandaraman Narasimhan, Wei Fun Cheong, Sharon Ng, Izzuddin M. Aris, See Ling Loy, Anne Bendt, Kok Hian Tan, Fabian Yap, Lynette P Shek, Yap Seng Chong, Peter Gluckman, Keith M Godfrey, Yung Seng Lee, Markus Wenk, Neerja Karnani, Shiao-Yng Chan
Dysregulated transplacental lipid transfer and fetal-placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60e6b9b7d24a03dce442412cebfb47eb
https://doi.org/10.21203/rs.3.rs-1781226/v1
https://doi.org/10.21203/rs.3.rs-1781226/v1
Autor:
Melvin Khee-Shing Leow, Anantharaj Rengaraj, Kothandaraman Narasimhan, Sanjay K. Verma, Jadegoud Yaligar, Giang Le Thi Thu, Lijuan Sun, Hui Jen Goh, Priya Govindharajulu, Suresh Anand Sadananthan, Navin Michael, Wei Meng, Xavier Gallart-Palau, Lei Sun, Neerja Karnani, Newman Siu Kwan Sze, S. Sendhil Velan
Publikováno v:
Bioscience Reports. 42
Brown adipose tissue (BAT) is a promising weapon to combat obesity and metabolic disease. BAT is thermogenic and consumes substantial amounts of glucose and fatty acids as fuel for thermogenesis and energy expenditure. To study BAT function in large